Lecture 32 : Drugs affecting Synaptic Transmission Flashcards
(9 cards)
1
Q
What characteristic must drugs have to have an effect on the CNS
A
Must cross blood brain barrier, so must be lipid soluble (unionsed at blood pH)
2
Q
Drugs which affect biosynthesis
A
L-DOPA is a precursor to dopamine which is given to treat parkinsons which is a deficit of dopamine release, and so more dopamine can be synthesised
3
Q
Drugs which affect action potential propagation
A
- Na+ channel blockers
- Treats epilepsy
4
Q
Drugs which affect neurotransmitte release
A
- Ca2+ channel blockers
- Phenytoin
5
Q
For receptors
A
- Antagonists
- Agonists
- Opioids
- Allosteric modulation of GABA receptors
6
Q
Depression
A
- Reuptake inhibition
- Degradative enzyme inhibition
7
Q
Parkinson’s Disease
A
- Direct agonism
- Reuptake inhibition
- Degrative enzyme inhibition
- Dopamine defecit
8
Q
Epilepsy
A
9
Q
Alzheimers
A
