Lecture 33 - Orexin Flashcards Preview

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Flashcards in Lecture 33 - Orexin Deck (12):
1

Where is the only place hypocretins are being produced?

the hypothalamus

2

What are the levels of orexin during sleep and when awake?

high during awake

low during sleep

3

Orexin 1 and oxrexin 2 work on _ receptors (GPCR)

2
Hcrt 1&2

4

Orexin neurons are active during ___ ___ ___ and silent during,,,

active during active wake state

silent during NREM and REM sleep stages

5

People suffering from nacrolepsy will have...

oscillating sleep/wake cycles - not the normal ones following the circadian rhythm

6

OX-a has a ___ bond

cysteine bond

7

There is a relationship between the lateral hypothalamus and drug dependence (morphine, cocaine) - so _____ _______ can be used as rteatment for addiciton

orexin antagonists

8

Orexin neurons promote wakefullness thoroguh the _________ _____ that are wake - active. Stimulation of dopaminergic centres by orexins can modulate _____systems

Orexin neurons promote wakefullness thoroguh the monoaminergic nucleui that are wake - active. Stimulation of dopaminergic centres by orexins can modulate reward systems

9

Peripheral metabolic signals such as leptin, ghrelin and glucose influence orexinnneuronal activity to coordinate .....

Peripheral metabolic signals such as leptin, ghrelin and glucose influence orexinnneuronal activity to coordinate arousal and energy homeostasis

10

What happens in the sleep state with regard to VLPO monoaminergic neurons in narcoleptic pateints?

nromally: VLPO takes over from the Orexin neurons in stimulating the monoaminergic neurons (which them stimualtes thalamus) - which puts peple to sleep

in narcolepsy: the orexin neurons aren't there so there is no switch - the signal just goes back and forth between the VLPD neurons and monoaminergic neurons

11

What does the orexin receptor blockade induce and maintain?

sleep without motor side effects

12

All 4 Ox1/Ox2 antagonists in development have the same issue being...

REM/NREM imbalance and strange pharmocokinetics