lecture 4- bioavailability Flashcards
adverse reaction
harmful or unpleasant rxn
what predicts hazard from future administrations
adverse rxns
ABCDEF adverse rxns
- augmented
- bizzarre
- chronic
- delayed
- end of use
- failure
difference between dose related and non dose related
dose-related is common and predictable vs non- is not and high mortality.. (allergic rxn)
dose and time related (chronic)
uncommon, related to cum. dose over time
adverse reaction 5 rights
right:
- drug
- patient
- dose
- route
- time
bioavailability can be altered by
- route of admin
- acid/base of drug
- acid/base of environment
- absorption
- bound/unbound
- first pass effect
- excretion/elimination
if a weak acid is 9.5 in a ph of 2 what happens?
it will protonate and absorb through
more polar (water) means ____ (charged or uncharged)
charged
lipid solubility is ____ proportional to its charge
inverse
difference between weak acid and bases
weak acid neutral form is protonated
-weak base unprotonated form is neutral
uncharged is more or less lipid soluble
more lipid soluble
charged is what kind of soluble
water soluble; polar
higher than 1 L per kilo
vd is high
units in kilo
1000 units
