Lecture 4: CVA Flashcards

1
Q

Types of Strokes

A

1) Hemorrhagic: 17%, occur as a result of bleeding in the brain due to an injury to head or ruptured aneurysm of a vessel (produce more fatalities)
2) Ischemic stroke: 83%, occur because of clot formation in blood vessels

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2
Q

Types of Hemorrhagic Strokes

A

1) Intracerebral Hemorrhage (59%)- occurs when defective artery in brain ruptures and surrounding area of brain fills with blood
2) Subarachnoid Hemorrhage (41%)- occurs when b. vessel on surface of brain ruptures and bleeds into subarachnoid space btwn skull

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3
Q

Types of Ischemic Strokes:

A

1) Cerebral Embolism (20%): result of clot (embolus) that forms in another part of body and is carried to brain, becoming lodged in artery that supplies blood to brain; flow is blocked
2) Artherosclerotic Cerebrovascular Dz (20%): stroke occurs due to severe arterial stenosis or occlusion due to severe arteriosclerosis and coexisting thrombosus
3) Lacunar Infacrts (25%): results from microatheroma, lipohyalinosis and other occlusive dz.’s of the small penetrating arteries in the brain (usually basal ganglia, pons, cerebellum)
4) Cryptogenic (30%): unknown cause

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4
Q

Lacunar Strokes

A
  • small infarctions occur secondary to small vessel damage

- usually resulting from HTN or DM

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5
Q

Most common areas affected by lacunar strokes

A

Basal ganglia and internal capsule!

-other areas affected: pons, cerebellum, thalamus

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6
Q

Clinical Features of Lacunar strokes

A

1) Pure Motor Hemiplegia
2) Pure Sensory Strokes
3) Ataxic Hemiparesis
4) Secondary Motor Syndrome
5) Dysarthria CLumsy hand syndrome

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7
Q

Pure Motor Hemiparesis

A
  • contralateral weakness involving face-arm-leg
  • limbs equally affected
  • lesions occur in pons or internal capsule
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8
Q

Pure Sensory Stroke

A

parathesias in face-arm-leg

-lesions occur in thalamus

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9
Q

Ataxic Hemiparesis

A

incoordination accompanied by weakness of some limbs

-lesions usually in pons

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10
Q

Secondary Motor Syndrome

A

causes weakness and sensory deficits of face-arm-legs

-lesions in posterior limb of internal capsule

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11
Q

Dysarthria Clumsy Hand syndrome

A

slurred speech with clumsy contralateral hand

-lesions in pontine or brainstem lacunes

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12
Q

MCA Infarction

A

contralateral hemiparesis, aphasia, homonymous hemianopsia

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13
Q

MCA infacrtion: Dominant side

A

Aphasia: Broca’s, Wernicke’s or global

Gaze preference: toward side of lesion

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14
Q

MCA stroke: non dominant side

A

Neglect, spatial disorientation: do not recognize anything on dominant side (so contralateral neglect)

also have agnosia-anosognosia

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15
Q

Anterior cerebral artery stroke

A

contralateral weakness: lower extremities and face

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16
Q

posterior cerebral artery stroke

A

homonymous hemianopsia contralateral to side involved: so R sided lesion cannot see L side

17
Q

Basilar Artery Stroke

A

may present with: quadriplegia, coma, altered consciousness, pupillary abnormalities, ocular palsy

18
Q

Basilar Artery Stroke: depend on CN involved

A

but remember: have ipsilateral deficit with CN nerves

Example: CN VII involvement: ipsilateral facial weakness: upper and lower

19
Q

With Basilar Artery stroke: Locked in syndrome

A

can only move eyes vertically

20
Q

Vertebral Artery Stroke

A

-sx’s similar to basilar artery: contralateral hemiplagia and sensory deficit and ipsilateral CN palsy

21
Q

Hemorrhagic Stroke: Etiology

A
  • **HTN
  • amyloid angiopathy
  • AV malformation
  • cavernous angioma
  • intracranial aneurysm
  • dural venous sinus thrombosis
  • coagulopathy
  • hemorrhagic conversion of infarction
  • neoplasm or infxn
22
Q

Intracerebral Hemorrhage

A

most common causes HTN

Other causes: bleeding disorders, anticoag therapy, liver dz, High EtOh or primary/secondary brain tumors

23
Q

Intracerebral hemorrhage sx’s

A

LOC, N/V, evoloving hemiplaegia or hemiparesis

24
Q

Thalamic hemorrhage

A

loss of upward gaze, downward or skew deviation, pupillary inequalities

25
Nonmodifiable risk factors for stroke
Age, Sex (male), race (AAs), prior stroke, fam hx
26
Modifiable risk factors for stroke
HTN, Hrt. Dz, smoking, TIA, Diabetes, High cholesterol, Wt
27
Specific cardiac risk factors for stroke
arrhythmia, valvular dz, endocarditis, aortic arch plaque, low ejection fraction, septal defect, CAD, anuerysm, atrial/ventr thrombosus
28
Other Risk factors
Migraine, coagulopathies, hemoglobinopathies (thalassemia, Sickle cell, TTP, congenital defects); malignancy, hyper coagulable state; Vasculitis/vasculopathy (SLE, secondary sylph); Drygs/medds; Infectious dz.'s; trauma; venous sinus thrombosis
29
Tx options
- IV TPA - Intra arterial TPA - Endovascular tx: penumbra, MERCI, angioplasty, stenting, microwire clot disruption - decompressive hemcraniotomy
30
IV TPA
-must be given in 3 hr window; window of 4.5 hrs accepted
31
Specific Inclusion criteria for IV TPA
-NO recent surgery or procedure involving non compressible site -INR < 1.7 -Glucose > 60, < 185/110 -platelet > 100,000 No h/o intracranial hemorrhage
32
Intra-arterial TPA
not FDA approved; deliver TPA directly into clot they artery -extends to a 6 hr window
33
Intra arterial TPA drawbacks
invasive procedure; limited hospitals can do procedure; does not help lacunar strokes
34
Work up of Strokes
- carotid doppler - Echo (TEE) - MRI/MRA: helps differentiate btwn new and old - Blood tests: HgA1c, lipid, syph, toxicology - Carotid endarterctomy - Carotid artery stent replacement
35
Meds for stroke
Anticoags/antiplatelets: ASA, plavix, aggrenox, Heparin/levanox/coumadin (reserved for embolic strokes)