Lecture 4 Vocab Flashcards
(20 cards)
what is the progenitor of the cells that give rise to connective tissue?
mesenchymal stem cells (MSC)
large cells, called _______ are responsible for storing lipids and are found in ________ tissue
unilocular adipocytes, adipose
lipid-storing cells specialized for heat production
multilocular adipocytes
cells responsible for production, remodelling, and degradation of ECM fibers and ground substance
fibroblasts
what do myofibroblasts do?
specialized type of fibroblast that produces myosin and is responsible for force generation
dominant fiber of connective tissue
type I collagen
triple-helix shaped molecules found in fibroblasts that are cleaved to become type I collagen
procollagen
repeating subunit of collagen fiber
fibril
main component of reticular fibers
type III collagen
does not assemble into fibers, but fibrils are visible in EM images
type II collagen
type II collagen is secreted by:
chondrocytes
what is the repeating subunit of type IV collagen?
meshwork of dimers
type of collagen found in basal lamina
type IV
type of collagen that secures connective tissue to basal lamina
type VII
explain how the three types of collagen interact to connect the basal lamina to the connective tissue
type VII collagen fibers connect from the collagen in the basement membrane (type IV) to strands of reticular fibers (type III)
found in the growth plates of bones
type X
basic building block of ground substance
GAG - a linear chain of dissacharide units
GAG bound to a protein
proteoglycan
describe how the ground substance is organized
GAGs attach to proteins, forming proteoglycans. these proteoglycans then attach to hyaluronic acid (a large, non-sulfated GAG). These molecules are very negatively charged and very hydrophilic, so they are hydrated easily.
name four typical GAGs (besides hyaluronic acid)
dermatan sulfate, heparan sulfate, keratan sulfate, chondroitin sulfate
