Lecture 5

Question 1

When you breathe in cold air what does the sinuses do?

Answer 1

Regulates the coldness and humidity to match what’s in your body

Question 2

What is the role of turbinates?

Answer 2

Help regulate the air and humidity as it passes through your nasal cavity

Question 3

What do goblet cells produce?

Answer 3

Mucus

Question 4

Define drug deposition

Answer 4

Where the drug is deposited in the nasal cavity

Question 5

Define mucosal absorption

Answer 5

How the drug is absorbed across the mucosa

Question 6

Define mucocilliary clearance

Answer 6

The movement of mucus layer to the nasopharynx

Question 7

What three properties affect how quickly a particle passes through nasal cavity?

Answer 7

Temperature, anatomy, and nasal clearance

Question 8

How often does mucus clear towards the nasopharynx?

Answer 8

10-20 mins

Question 9

Where do particles land?

Answer 9

Ciliated regions, non-ciliated regions, nasopharynx

Question 10

What are the drug formulation requirements?

Answer 10

Even distribution in the nasal cavity, ensure it does not impact ciliary action negatively

Question 11

What does the mucus layer consist of?

Answer 11

Mainly water, some salts, lipids and proteins