Flashcards in Lecture 5 - Hormones and Exercise Deck (19):
What are the metabolic actions of insulin?
Increases muscle glucose uptake
Activates glycogen synthase
Inhibits liver glucose production
What are the metabolic actions of glucagon?
Stimulates liver glycogenolysis
Increases activity of gluconeogensis enzymes in liver
plasma insulin levels ___ during exercise
glucagon really responds to a fall in ____
Increases in sympathetic activity during exercise inhibits...
the release of insulin from the pancreas
A single bout of exercise increases insulin...
promotes the storage of glucose as glycogen
What are the effects of training on distal insulin signalling
Greater insulin response when trained
increase in GLUT 4 expression
increase in Hexokinase, glycogen synthase - glucose metabolism up
muscle oxidative capacity
increase in muscle blood flow - vasodilation is higher in trained state
increase incapillary density / recruitment - more of them
(there will be higher muscle glycogen levels at rest because of these adaptations)
What are the metabolic actions of adrenaline:
Increases muscle glycogenolysis (beta2 receptor)
Enhanced liver glucose output (not sure which receptor)
Stimulates lipolysis (beta1 + beta2 ?)
An increase in the plasma levels of adrenaline is a sign of...
exercise intensity - not all of the adrenaline is re-uptaked
reflects the increase sympathetic nerve activity
Sympathetic impact on the adrenal medulla causes...
release of adrenaline
The longer the duration of exercise the more progressive rise in ...
What are the situations in which Sympathoadrenal activity increase?
increases in exercise intensity
increases over time, at a given intensity
Why does Sympathoadrenal activity increase over time?
you get hotter, blood glucose goes down all of which activates it
What are the metabolic actions of cortisol?
Decreases muscle glucose uptake
Increases muscle proteolysis (breakdown)
Increases gluconeogenesis and liver glycogen synthesis
cortisol can be an indicator of...
What are the metabolic actions of growth hormone in exercise?
Increases production of IGF (insulin growth factors - effects connective tissue formulation)
Decreases muscle glucose uptake (spares it for the brain)
Increases AA uptake and protein synthesis
How do working muscles and motor CNS centers send impulses to regulate hormonal response to exercise?
Which hormones are release?
There is an increase in sympathoadrenal activity
(decrease insulin, increases renin/gastrin)
Hormones: GH, ACTH, PRK, TSH released (from pituitary)