Lecture 5 - Hormones and Exercise Flashcards Preview

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Flashcards in Lecture 5 - Hormones and Exercise Deck (19):
1

What are the metabolic actions of insulin?

Increases muscle glucose uptake

Activates glycogen synthase

Inhibits liver glucose production

Inhibits Lipolysis

2

What are the metabolic actions of glucagon?

Stimulates liver glycogenolysis

Increases activity of gluconeogensis enzymes in liver

stimulates lipolysis

3

plasma insulin levels ___ during exercise

fall

4

glucagon really responds to a fall in ____

Glucose

5

Increases in sympathetic activity during exercise inhibits...

the release of insulin from the pancreas

6

A single bout of exercise increases insulin...

sensitivity

7

Glycogen synthase...

promotes the storage of glucose as glycogen

8

What are the effects of training on distal insulin signalling

Greater insulin response when trained

increase in GLUT 4 expression

increase in Hexokinase, glycogen synthase - glucose metabolism up

muscle oxidative capacity

increase in muscle blood flow - vasodilation is higher in trained state

increase incapillary density / recruitment - more of them

(there will be higher muscle glycogen levels at rest because of these adaptations)

9

What are the metabolic actions of adrenaline:

Increases muscle glycogenolysis (beta2 receptor)

Enhanced liver glucose output (not sure which receptor)

Stimulates lipolysis (beta1 + beta2 ?)

10

An increase in the plasma levels of adrenaline is a sign of...

exercise intensity - not all of the adrenaline is re-uptaked

reflects the increase sympathetic nerve activity

11

Sympathetic impact on the adrenal medulla causes...

release of adrenaline

12

The longer the duration of exercise the more progressive rise in ...

adrenaline

13

What are the situations in which Sympathoadrenal activity increase?

increases in exercise intensity

increases over time, at a given intensity

14

Why does Sympathoadrenal activity increase over time?

you get hotter, blood glucose goes down all of which activates it

15

What are the metabolic actions of cortisol?

Decreases muscle glucose uptake

Increases muscle proteolysis (breakdown)

Increases gluconeogenesis and liver glycogen synthesis

Increases lipolysis

16

cortisol can be an indicator of...

over-training

17

What are the metabolic actions of growth hormone in exercise?

Increases production of IGF (insulin growth factors - effects connective tissue formulation)

Decreases muscle glucose uptake (spares it for the brain)

Increases gluconeogenesis

Increases lipolysis

Increases AA uptake and protein synthesis

18

How do working muscles and motor CNS centers send impulses to regulate hormonal response to exercise?

Which hormones are release?

There is an increase in sympathoadrenal activity
(decrease insulin, increases renin/gastrin)

Hormones: GH, ACTH, PRK, TSH released (from pituitary)

19

Myokines are released from ...

contracting muscle - acts as an endocrine organ

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