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Flashcards in Lecture 5 Immunotherapy Deck (11)
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1

What vascular changes occur during hyper-acute rejection

Complement activation
Endothelial damage
Inflammation
Thrombosis

2

What vascular changes occur during acute rejction

Parenchymal damage
Interstitial inflammation
Endotheliatitis

3

What vascular changes occur during chronic rejection

Chronic inflammatory reaction in vessel wall
Intimal smooth muscle cell proliferation
Vessel occlusion

4

Name licensed indications for IVIg

Primary immunodeficiency
Idiopathic Thrombocytopenic Purpura
Kawasaki disease
Children with HIV
Multiple myeloma/CLL

5

Name 3 examples of direct immunotherapy

Monoclonal antibodies
Chimeric antigen receptors
Bi-specific antibodies

6

Are Tumour factors direct or indirect immunotherapy

Indirect

7

What is the first line treatment for non-Hodgkin's Lymphoma

Rituximab

8

Anti-TNF therapy Infliximab is used to treat what kind of disease

Autoimmune
Ankylosing spondylitis
Crohn's disease
Ulcerative colitis
RA

9

What are checkpoint inhibitors

Unlock the gateway to the adaptive immune system
Powerful anti-tumour responses

10

How do tumour cells inhibit T cell killing

PDL-1 on the tumour cell binds to PD-1 on the T cell and inhibits T cell killing of the tumour cell

11

What is CAR T Cell Therapy

T cell engineered to express antigen-targeted receptors specific for tumour antigens