Lecture 5 - Sympathetic (Adrenergic) Pharmacology Flashcards Preview

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Flashcards in Lecture 5 - Sympathetic (Adrenergic) Pharmacology Deck (150)
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1

Two types of cholinergic receptors?

nicotinic
muscarinic

2

______: ligand-gated ion channel, membrane depolarization

nicotinic

3

What do M1, M3, and M5 do?

activates PLC
increases Ca2+
activates PKC

*causes excitation
gastric release, smooth muscle, gladder, etc.

4

What do M2, and M4 do?

inhibits AC (adenylate cyclase)
activates K+ channels
inhibits PKA

*inhibition of cardiac and smooth muscle

5

What do alpha 1 adrenergic receptors do?

activates PLC
increases Ca2+

causes smooth muscle contraction (vasoconstriction, sphincter, mydriasis)

6

What do alpha 2 receptors do?

INHIBITS THE SYSTEM THAT RELEASES IT

-inhibits AD
-increases K+
-hyperpolarization

this inhibits NE release
this inhibits insulin release
-presynaptic neuron pancreatic B cells ???

7

What do B receptors do?

activates AC
increase PKA activation

heart, lung, and energy regulation

Increases:
-heart rate
-contractility
-bronchodilation
-vasodilation
-glyconeogenesis
-lipolysis

8

Parasympathetic:
constrict pupils

M3

9

Parasympathetic:
stimulate salivation

M3

10

Parasympathetic:
slow heart rate

M2

11

Parasympathetic:
constrict airways

M3

12

Parasympathetic:
stimulate activity of stomach

M3

13

Parasympathetic:
-inhibit release of glucose
-stimulate gall bladder

I assume it's M3

14

Parasympathetic:
stimulate activity of intestine

M3

15

M odd = ?

stimulatory

16

M even = ?

relaxation

17

Parasympathetic:
contract bladder

M3

18

Sympathetic:
dilate pupils

alpha 1

19

Sympathetic:
inhibit salivation

beta

20

Sympathetic:
increase HR

B1

21

Sympathetic:
relax airways

B2

22

Sympathetic:
inhibit activity of stomach

B2

23

Sympathetic:
stimulate release of glucose and inhibit gallbladder

B2

24

Sympathetic:
inhibit activity of intestine

B2

25

Sympathetic:
secrete epinephrine and NE

nicotinic

26

Sympathetic:
relax bladder

B2

27

Sympathetic:
promote ejaculation and vaginal contraction

alpha 1

28

For pupil opening:
-sympathetic acts on what muscle ?

radial muscle of iris

contraction (alpha 1)

mydriasis (pupil dilating)

29

For pupil opening:
-parasympathetic acts on what muscle ?

circular muscle of iris

contraction (M3)

miosis

30

For lens focusing:
-parasympathetic acts on what muscle?

ciliary muscle

contraction (M3)

near vision