lecture 8 steroids Flashcards Preview

Ocular Pharm lectures 6-9 final > lecture 8 steroids > Flashcards

Flashcards in lecture 8 steroids Deck (28)
Loading flashcards...
1

Dexamethasone inhibits the production of which one of the following?

a) leukotrienes
b) prostaglandins
c) platelet activating factor (PAF)
d) the entire arachidonate pathway

d) the entire arachidonate pathway, --dexamethasone is a steroid

2

steroid hormones have _____ backbones

cholesterol

3

name the 4 types of steroids

1) glucocorticoids 2) mineralocorticoids 3) sex hormones 4) vitamin D

4

The ketone version of cortisol is ____ and the aldehyde version of cortisol is _____

cortisone, hydrocortisone

5

what is the most common oral steroid?

prednisone

6

Between prednisone and predniSOlone, which is the active ketone (meaning immediate action without the conversion step)?

predniSOlone is the active one

7

What does HPA in the HPA axis stand for?

Hypothalamus, anterior Pituitary, and Adrenal gland.

8

Which corticosteroid is the least potent?

cortisone

9

(T or F) steroids activate the flight or fight response acting like stress on the HPA axis

True

10

(Tor F) cortisol levels are lowest in the morning and peak in the evening

false, cortisol is highest in the morning (fight or flight) and decrease in the evening (rest and digest)

11

(T or F) steroids are anti-inflammatories as well as immuno-suppresants

true

12

select the correct statement:

a) steroids can cause alteration of mood (bouts of rage)
b) steroids act secondarily as an antibiotic
c) steroids decrease blood pressure
d) steroids decrease production of RBC's as a means to reduce oxygen carrying capacity

a) steroids can cause alteration of mood (bouts of rage)

13

Would a steroid increase or decrease fibroblast production?

decrease, fibroblasts are used to repair/heal tissues and steroids inhibit healing

14

Aldosterone is a ________ used for fluid retention

a) glucocorticoid
b) mineralocorticoid
c) sex hormone
d) NSAID

b) mineralocorticoid

15

Your patient has an eye infection that is red, inflamed, and very painful. During your slit lamp exam, you notice the corneal epithelium is also damaged. Is a topical steroid ok to use on this pt?

no, steroids inhibit healing. you would want to use an antibiotic and that should resolve the inflammation. You could, however, use a topical steroid once the cornea is healed if swelling still persists.

16

Which of the following is NOT a systemic contraindication for use of steroids

a) osteoporosis
b) peptic ulcer
c) fungal infection
d) hypotension

d) hypotension.....steroids can cause hypertension, therefore steroids would be contraindicated in patients with hypertension

17

there is a drug interaction with steroids and which 3 drugs (combination of steroids and these causes enhanced metabolism of steroids)

barbituates, phenylbutazone, and phenytoin

18

(T or F) Steroids should not be taken with anticoagulants such as aspirin and coumadin due to increased anti-coagulant effects

false, steroids decrease anticoagulant effects

19

hypo-secretion of steroids from the adrenal cortex describes what disease?

addisons

20

what are xanthomas?

lipid deposits on the skin

21

what does a person with cushings syndrome have all over their body?

xanthomas

22

Cushing syndrome is an adverse of effect of which of the following?

1) steroids
2) vitamin D deficiency
3) NSAIDS
4) narcotics

1) steroids

23

which is the most potent topical steroid for eyecare?

a) Durezol
b) prednisone
c) predniSOlone
d) FML

a) Durezol

24

which is the only topical steroid ester in eyecare?

a) Pred Forte
b) Vexol
c) Lotemax
d) Alrex

c) Lotemax (also the only preservative free eye ointment)

25

Which is the least potent of the topical steroids?

a) Pred Forte
b) Pred mild
c) Durezol
d) Lotemax

b) Pred mild

26

Why is it important to know what topical steroid is an ester?

ester based topicals are rapidly metabolized, less side effects, and you wouldnt want to use them with deeper inflammation. Also esters are less like to increase IOP and have less risk for cataracts (Lotemax is the only ester based steroid topical)

27

topical steroids are indicated for which type of herpes?

herpes zoster but contraindicated for simplex

28

steroids in general have associated risks with increased IOP and cataracts. in regards to oral vs topical, which ones have increased risk with which condition.

oral-->cataracts
topical-->increased IOP