Lecture 9&10 Flashcards
(15 cards)
adaptive immunity is triggered by capturing and presenting of foreign materials to cells that can recognize it, the cells that recognize are called
APCs (antigen processing cells)
list the 3 main APCs
dendritic cells (MOST IMPORTANT)
macrophages
B-cells
only ___________ cells can activate naïve and trigger a ____________________
dendritic cells
primary immune response
APCs capture foreign microbes or their products or their products and process large proteins by breaking them into peptides and ________ on their surfaces attached to specialized antigen-presenting structures called ___________________
presenting
Major Histocompatibility Complex (MHCs)
B cells and macrophages present antigen to ______________
memory T helper cells
secondary immune
Dendritic cells are present primarily in _____________ and _____________
epithelial tissues
lymphoid organs
3 major functions of dendritic cells
- serve as sentinel cells– activate innate defenses
- process exogenous antigens- initiate adaptive immune system
- regulate adaptive immunity – release cytokines based on pathogen type
DC cells take up things like dead microorganisms, soluble antigens, and ________________
antigen released by dead cells
langerhans cells
present in skin
looking for foreign particles
follicular dendritic cells are different from other DC in that they:
dont migrate
are located in lymphoid follicles (B-cell area)
lack MHC 2 molecules on their surface
carry many complement and Fc receptors
what do follicular dendritic cells do
can retain antigens for many weeks
present antigen to B-cells
DON’T PROCESS ANTIGEN
immune complexes for spherical bodies on the dendrites
iccosomes
iccosomes break off the dendrites and attach to
B-cells
when DCs stimulate T helper cells they provide three signals.
what happens in the first signal
when DCs stimulate T helper cells they provide three signals.
what happens in the second signal
