Lecture 9 - Anxiolytic Drugs Flashcards
(16 cards)
Anxiety is the state of ____, ____, ___, accompanied by ____, ____, ____, and ____ (_____ activation).
Tension, apprehension, uneasiness.
Tachycardia, sweating, trembling, & palpitations.
Sympathetic
Anxiolytics drugs are only used in __________. Since the agents cause ____, they are clinically useful as anxiolytics and ____ (sleep inducing).
chronic debilitating anxiety.
sedation
hypnotic
_________ are the most widely used agents replacing barbiturates as anxiolytic treatment because of ___ and ___
Benzodiazepines
Safety
Effectiveness
Benzodiazepines mechanism: Bound to specific high affinity sites adjacent to ______ receptors, enhancing affinity in CNS. Resulting in more frequent activation of ___ channels.
GABA
Cl-
Actions of benzodiazepines are….
The reduction of anxiety by selective inhibiting neuronal circuits in the limbic system
True or False?: Benzodiazepines have anti-psychotic or analgesic action.
False! The have NO anti-PSYCHOtic or ANALgesic ACTION
The therapeutic use of benzodiazepines is for _____, ______, ______, _____
Anxiety(depression and schizophrenia),
muscle spasms(cerebral palsy, MS),
Seizure disorders(diazepam),
Sleep disorders.
The drug of choice for grand mal epileptic seizure and status epilepticus is…..
Diazepam
The lethal dose of benzodiazepines
1000x greater than the typical therapeutic dose
What are the duration of actions of benzodiazepines?
Long-acting - 1 - 3 days
Intermediate acting - 10 - 20 hours
Short-acting 3 - 8 hours
Benzodiazepines are ____ absorbed PO, they are metabolized in the ____, and excreted in urine in ____ form.
well
Liver
glucuronide
The adverse effects of benzodiazepines are:
Psychological and physical dependence, withdrawal symptoms, decreases motor coordination, cognitive impairment, decrease long term memory and new knowledge.
What are the withdrawal symptoms after abrupt use.
Confusion, anxiety, restlessness, insomnia and tension.
Benzodizepines should be used cautiously in _____ and may potentiate _____ and other _____ agents.
liver
alcohol
depressant
What are six anxiolytic drugs?
Alprazolam Chlordiazepoxide Clonazepam Clorazepate Diazepam Lorazepam
What are six hypnotic drugs?
Quazepam Midazolam Estazolam Flurazepam Temazepam Triazolam
