Lecture | Midterms Review

Question 1

Bleeding time is used to evaluate the activity of:

A. Platelets
B. Prothrombin
C. Factor xiii
D. Labile factor

Answer 1

Platelets

Question 2

Which of the following test results is normal in a patient with classic Von willebrand’s disease?

APTT
Bleeding time
Platelet count
VWF level

Answer 2

Platelet count

Question 3

No bleeding is observed in a deficiency of which of the following factors?

II
XII
IX
VIII

Answer 3

XII

Question 4

Hemolytic uremic syndrome is associated with:

Fever and thrombocytosis
Granulocytosis
E. coli
Leukocytosis

Answer 4

E. coli

Question 5

Coagulation factors affected by coumarin drugs:

VIII, IX, and X
I, II, V, and VII
II, VII, IX, and X
II, V, and VII

Answer 5

II, VII, IX, and X

Question 6

Thrombotic thrombocytopenic purpura is characterized by:

Prolonged pt
Increased platelet aggregation
Thrombocytosis
Prolonged aptt

Answer 6

Increased platelet aggregation

Question 7

A protein that plays a vital role in both coagulation and platelet aggregation?

I
Xl
Vlll
IX

Answer 7

I

Question 8

The defect characterizing Gray’s syndrome:

Platelet adhesion
Dense granule
Alpha granule
Coagulation defect

Answer 8

Alpha granule

Question 9

Factor XIII is caused by which factor?

Ila
Va
Xa
Fibrinogen

Answer 9

Ila

Question 10

Factor V is a cofactor to factor X to activate factor Il.
T/F

Answer 10

True

Question 11

What clotting factors are inhibited by proteins?

V and X
V and VIII
VIl and IX
VIII and X

Answer 11

V and VIII

Question 12

What is the second phase of secondary homeostasis?

Contact phase
Activation of factor vii
Activation of factor x
Formation of fibrin cot

Answer 12

Activation of factor x

Question 13

Several hours after birth, a baby develops petechiae and a hemorrhagic diathesis. Platelet count is 8,000/ul. What is likely the explanation?

Drug-induced thrombocytopenia
Secondary thrombocytopenia
Isoimmune neonatal thrombocytopenia
Neonatal DIC

Answer 13

Isoimmune neonatal thrombocytopenia

Question 14

When performing platelet aggregation studies, which is most likely associated with Bernard soulier’s syndrome?

Decreased with ADP
Normal to epinephrine, decreased to ristocetin
Normal to epinephrine and ristocetin, decreased with collagen
Normal to collagen, ADP, and risfaceton

Answer 14

Normal to epinephrine, decreased to ristocetin

Question 15

Which of the following is a characteristic of acute idiopathic thrombocytopenic purpura?

Insidious onset
Spontaneous remission within a few weeks
Predominantly seen in adults
Nonimmune platelet destruction

Answer 15

Spontaneous remission within a few weeks

Question 16

Factor xiii is a serine protease

T/f

Answer 16

False

Question 17

Which of the following inhibitors inhibit factor IIa?

Protein C
Antithrombin III
Both
Neither

Answer 17

Both

Question 18

Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?

Autoimmune disease
Decreased VWF
Decreased platelet aggregation
Decreased platelet adhesion

Answer 18

Autoimmune disease

Question 19

TAFI target protein:

TFPI
Fibrinogen
Fibrin
VwF

Answer 19

Fibrin

Question 20

Which step requires calcium?

Factor VII activation
Factor XII activation
Factor XIII activation
Factor I activation

Answer 20

Factor XIII activation

Question 21

Giant platelet is associated with which condition:

Bernard soulier syndrome
Glanzmann’s thrombasthenia
Gaucher’s disease
All of the choices

Answer 21

Bernard soulier syndrome

Question 22

Platelet abnormality will affect both bleeding time and clotting time.
T/F

Answer 22

True

Question 23

Which of the following is associated with post transfusion purpura?

Non-immune thrombocytopenia / alloantibodies
Immune mediated thrombocytopenia / autoantibodies
Both of the above
Autoantibodies

Answer 23

Immune mediated thrombocytopenia / autoantibodies

Question 24

Thiazide diuretics results to?

Decreased platelet production
Decreased platelet survival
Both
Neither

Answer 24

Decreased platelet production

Question 25

Which of the following factors is used only in the extrinsic coagulation pathway ? II VII V VIII

Answer 25

VII

Question 26

Hereditary hemorrhagic telangectasia is a disorder of? Platelets Clotting proteins Fibrinolysis Connective tissue

Answer 26

Connective tissue

Question 27

Which of the following coagulation factors is considered to be labile? II III V VII

Answer 27

V

Question 28

What role does vitamin K play in the prothrombin group? A. Provides surface on which the proteolytic reaction occurs B. Protects them from inappropriate activation by compounds such as thrombin C. Accelerates the binding of the serine protease and their cofactors D. Carboxylates the factors to allow calcium binding

Answer 28

D. Carboxylates the factors to allow calcium binding

Question 29

Factor I deficiency will affect APTT and PT. T/F

Answer 29

True

Question 30

Aspirin prevent platelet aggregation by inhibiting the action of which enzyme? Prostacyclin Synthes Phospholipase Cyclooxygenase TXA2 synthase

Answer 30

Cyclooxygenase

Question 31

Which statement regarding proteins C is correct: Vitamin K independent Fibrinogen activated Activates V & VIII Activity is enhanced by protein S

Answer 31

Activity is enhanced by protein S

Question 32

Thrombocytopenia may be associated with: Postsplenectomy Myeloproliferation Hypersplenism Acute blood loss

Answer 32

Hypersplenism

Question 33

The APTT is sensitive to a deficiency of which clotting factor? Calcium X Both None

Answer 33

None

Question 34

Which off the following factors will activate factor XI? Stuart factor Fibrinogen Hageman factor Plasma thromboplastin antecedent

Answer 34

Hageman factor

Question 35

Lumi-aggregation measures: Platelet aggregation Aggregation and ATP release Platelet adhesion GP1b

Answer 35

Aggregation and ATP release

Question 36

APTT is used to? Monitor heparin therapy Evaluate the common pathway Both None

Answer 36

Both

Question 37

Neurologic findings, maybe commonly associated with which of the following disorders? HUS TTP ITP PTP

Answer 37

TTP

Question 38

True of TTP & DIC: APTT prolonged in DIC Schistocytes are present in DIC Platelet is decreased in TTP PT is decreased in DIC

Answer 38

APTT prolonged in DIC

Question 39

Which of the following is most likely to be abnormal in patients taking aspirin? Platelet morphology Platelet count Bleeding time Prothrombin time

Answer 39

Bleeding time

Question 40

Platelet aggregation response for Glanzmann thrombasthenia: Normal to ADP, decreased to ristocetin Normal Ristocetin, decreased to Epinephrine Normal aggregation to collagen, decreased to ADP and Ristocetin Normal to ADP and Ristocetin, decreased to collagen

Answer 40

Normal Ristocetin, decreased to Epinephrine

Question 41

Thrombin-Thrombomodulin complex is necessary for the activation of: Protein C Antithrombin Protein S Factor V and VII

Answer 41

Protein C

Question 42

Scott syndrome will affect which of the following? Platelet adhesion Vasoconstriction Secondary homeostasis Fibrinolysis

Answer 42

Secondary homeostasis