lectures 6 and 7: Haemoglobin and gas transport Flashcards Preview

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Flashcards in lectures 6 and 7: Haemoglobin and gas transport Deck (17)
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1
Q

how much oxygen is in each litre of systemic arterial blood

A

200ml

2
Q

what is the major determinant of the degree to which haemoglobin is saturated with oxygen

A

partial pressure of oxygen in arterial blood

3
Q

At the normal systemic arterial Po2 of 100mmHg what is the saturation of Haemoglobin

A

almost 100 percent

4
Q

does foetal haemoglobin have a higher or lower affinity for o2 than HbA

A

higher, this is necessary for extracting o2 from maternal/arterial blood

5
Q

define Anaemia

A

any condition where the oxygen carrying capacity of the blood is compromised

6
Q

what are the conditions that facilitate the dissociation of oxygen from haemoglobin (aka the affinity of haemoglobin for oxygen is decreased)

A

decrease in pH
increase in Pco2
increase in temperature

7
Q

what are the conditions that make oxygen uploading more difficult but aid the collection of oxygen (aka the affinity of haemoglobin for oxygen is increased)

A

Increase in pH
decrease in Pco2
decrease in temperature

8
Q

what does the binding of 2,3-DPG to Hb do to its affinity for Oxygen

A

the affinity of Hb for oxygen is increase by the binding of 2,3-DPG

9
Q

when in 2,3-DPG synthesised

A

in situations with inadequate oxygen supply and helps maintain oxygen release in the tissues

10
Q

define hypoxia

A

deficiency of oxygen reaching the tissues

11
Q

define hypoxic hypoxia

A

most common- reduction in o2 diffusion at lungs

12
Q

define anaemic hypoxia

A

reduction in o2 carrying capacity of blood due to anaemia

13
Q

define Ischaemic hypoxia

A

heart disease results in inefficient pumping of blood to lungs/around the body

14
Q

define histotoxic hypoxia

A

poising prevents cells utilizing oxygen delivered to them for example carbon monoxide poising or cyanide

15
Q

define metabolic hypoxia

A

oxygen delivery to the tissues does not meet increased oxygen demand by cells

16
Q

during hypo-ventilation will you get an increase or decrease in H+ levels

A

increase as there is too much co2 in the blood aka respiratory acidosis

17
Q

during hyperventilation will you get an increase or decrease in H+ levels

A

decrease as there is less co2 in the blood aka respiratory alkosis