Lecure 6 - Cardiac ElectroPhysiology Flashcards Preview

FHB Exam 1 - Cardiovascular Physiology > Lecure 6 - Cardiac ElectroPhysiology > Flashcards

Flashcards in Lecure 6 - Cardiac ElectroPhysiology Deck (54)
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1

What are specialized regions of intercellular connections between cardiac cells called?

Intercalated disks

2

What are the 3 types of junctions within an intercalated disk?

1. Fascia Adherens
2. Macula Adherens
3. Gap Junctions

3

What are the anchoring sites for actin that connect to the closest sarcomere?

Fascia Adherens

4

What adhering junctions have low resistance connections that allow current (Action potentials) to conduct between cardiac cells?

GAP JUNCTIONS

5

What holds cells together during contraction by binding intermediate filaments, joining cells together like a SPOT WELD?

Macula Adherens

- DESMOSOMES

6

What is HEALING OVER?

an increase in INTERNAL RESISTANCE that results from a decrease in the # of open gap junctions

7

What are 2 causes of healing over?

1. Increase in intracellular (cytosolic) Ca2+

2. increase in intracellular H+ ions (decrease ph)

- Ca is usually LOW in the cell

8

What is a clinical application of HEALING OVER?

Electrical isolation of damaged tissue that results from Myocardial Infarction

9

Describe the following for SA & AV Nodes:

1. Function
2. Conduction ( slow/fast)
3. Contraction (weak/strong)
4. DIAMETER
5. # of Gap Junction connections
6. Myofibrils

1. Pacemaker activity

2. SLOW CONDUCTION

3. WEAK CONTRACTION

4. small diameter (large internal resistance, small space constant)

5. few gap junctions

6. few Myofibrils

10

Describe the following for Atrium and Ventricles:

1. Function
2. Conduction ( slow/fast)
3. Contraction (weak/strong)
4. DIAMETER
5. # of Gap Junction connections
6. Myofibrils

1. Conduction/ Contraction

2. Fast conduction

3. STRONG contraction

4. medium diameter

5. Abundant gap junctions

6. Abundant MYOFIBRILS

11

Describe the following for His Bundle, Bundle Branches, and Purkinje Fibers:

1. Function
2. Conduction ( slow/fast)
3. Contraction (weak/strong)
4. DIAMETER
5. # of Gap Junction connections
6. Myofibrils

1. VERY RAPID CONDUCTION!!!!!!!!!!!!

2. VERY RAPID conduction

3. weak contraction!

4. LARGE DIAMETER

5. abundant gap junctions

6. FEW MYOFIBRILS

12

What factors determine cardiac conduction?

1. Space Constant

2. Rate of Rise AND Amplitude of Action Potential

13

How is Rm (membrane resistance) related to K+ permeability?

INVERSLEY related

-as membrane resistance decreases, K+ permeability increases

14

How is Ri (internal resistance) related to gap junctions and cell diameter?

- Inversely related to both

- internal resistance decreases with GREATER number of GAP JUNCTIONS and a GREATER CELL DIAMETER

15

How is the space constant defined by Rm and Ri?

space constant = (Rm/Ri) 1/2

(square root)

16

What 3 factors determine the rate of rise AND amplitude of AP?

1. Level of Resting Membrane Potential (fast -response only)

2. Slow vs. fast response AP's

3. Premature Responses initiated during RELATIVE REFRACTORY period

17

At what mV is the number of NA+ channels maximum? When is it ZERO?

1. Max at about -80, -90

2. Zero at -50

(at -60 = 50% of Na channels open OR conductance)

18

What defines conductance?

The number of channels open or closed

19

What are 3 conditions that influence the AP upstroke (depolarization phase- Na influx) as a result of changes in the RMP?

1. Hyperkalemia (more positive RMP)

2. Premature Excitation during relative refractory period

3. Ischemia or Myocardial Injury

20

An abnormal increase in EXTRACELLULAR K+ will cause a more positive or negative RMP?

- What CHannels are inactivated as a result?

More POSITIVE

- fast Na channels are inactivated

21

If Na channels are inactivated due to increase in extracellular K+, what happens to the rate of rise & amplitude size?
What is the MAJOR result of this?

1. SLOWER rate of rise,

2. Decrease Amplitude AP

3. SLOWER CONDUCTANCE!!!! of the AP

22

During ischemia/infarct, what can leak out of damaged cells?

K+ ions

- accumulate in interstitial (extracellular) fluid bathing the cells

- LOCAL concentration of K+ can increase to 20 mEq/L ( normal is 4)

23

An increase in interstitial (extracellular) K+, causes what change to the voltage?

MORE POSITIVE VOLTAGE (positive RMP)

- since K+ moving from high to low, thus moving IN to the cell instead of out

- inactivates Na channels

24

What is a major cause of arrhythmia? How is this defendant on K+ concentration and Na+ channel?

1. SLOWER CONDUCTANCE

2. If K+ higher outside cell, RMP is positive, thus cell depolarizes and Na channels inactivated

3. If fast Na channels inactivated in a damaged region = SLOWER CONDUCTION

(reliant on slow Ca2+ channels)

25

What interval on an EG is responsible for the conduction time of Atria to Ventricular Muscle? For Intra- Ventricular Conduction time?

1. P-R interval

2. QRS interval

26

Does Atrio-Ventricular delay or increase conduction?

DELAY to increase optimal ventricular filling

27

The AP of Atrio-Ventricular conduction is slow or fast?

SLOW conduction= slow response AP due to slow inward Calcium current

28

Atrio-Ventricular conduction (AV Node) has a long or short refractory period? What is the function of this?

LONG refractory period

- long because if protects the ventricles from abnormally HIGH ATRIAL rates = Atrial Flutter/Fibrillation

- AV conduction time determined by P-R interval

29

Describe the following blocks in AV Nodal Abnormalities:

1st Degree Heart Block
2nd Degree Heart Block
3rd Degree

1. abnormally prolonged P-R interval (more than 200 milliseconds or 0.2 seconds)

2. Atrial Impulses fail to activate ventricles, not all P waves followed by QRS complex

3. complete AV nodal bloc, no consistent P-R interval

30

The following describes 1st, 2nd, or 2rd degree block:

complete AV nodal bloc, no consistent P-R interval

3rd