Leukemia

Question 1

Diagnosis of CML

Answer 1

FISH for t(9;22) Ph chromosome or PCR analysis for the bcr/abl fusion gene

Question 2

treatment of CML

Answer 2

imatinib mesylate (Gleevec) –> tyrosine kinase inhibitor –> decrease in phosphate d/t phosphaturia

Question 3

diagnosis of AML

Answer 3

BM biopsy and cytogenetic studies

Question 4

dx of Acute promyelocytic leukemia M3

Answer 4

Myeloperoxidase stain + t(15;17), Auer rods

Question 5

treatment of AML
< 50 yo?
> 50 yo?
M3

Answer 5

< 50 yo: Allogeneic BMT if medical management does not work
both: ara-C (cytarabine) and DNR (daunorubicin)
M3 –> all-trans retinoic acid + arsenic trioxide

Question 6

CLL: lymphocytes express T cell marker CD? and B cell marker CD?

Answer 6

T cell CD 5

B cell CD 20 and CD 23

Question 7

CLL Treatment
Asymptomatic
symptomatic <65 yr
symptomatic >65 yr
for infections:

Answer 7

Asympatomatic - no tx
symptomatic <65 yr - fludarabine, chlorambucil, rituximab
symptomatic >65 yr - ibrutinib
for infections: IVIG (q monthly)

Question 8

indications for treatment in CLL

Answer 8

lymphocytosis + anemia Hgb <11 g or

lymphocytosis + thrombocytopenia <100,000

Question 9

tx for hairy cell leukemia

Answer 9

Cladribine –> add rituximab

“Cla ri with long hair”