Leukocyte Disorders 2

Question 1

generalized neoplastic proliferation or
accumulation of leukopoietic cells with or without
involvement of the peripheral blood

Answer 1

leukemia

Question 2

group of malignant disorders affecting blood and
blood forming tissue of the bone marrow, lymph system and spleen

Answer 2

leukemia

Question 3

the most common form of leukemia in children
characterized by a rapid increase in the numbers of immature blood cells

Answer 3

acute leukemia

Question 4

characterized by the excessive
build-up of relatively mature, but
still abnormal, white blood cells

Answer 4

chronic leukemia

Question 5

the predominant cells are all cells coming from
common myeloid progenitors

Answer 5

Granulocytic or Myelocytic Leukemia

Question 6

common lymphoid progenitors

Answer 6

Lymphocytic/Lymphoid Leukemia

Question 7

presence of immature or abnormal cells with WBC count greater than 15 x 10⁹/L

Answer 7

leukemic leukemia

Question 8

with immature or abnormal cells in peripheral
blood and with WBC count less than 15 x 10⁹/L

Answer 8

SUBLEUKEMIC LEUKEMIA

Question 9

with no immature cells in the peripheral blood and with WBC count less than 15 x 10⁹/L

Answer 9

ALEUKEMIC LEUKEMIA

Question 10

a type of myeloblastic leukemia
malignant green colored tumor of myeloid cases

formation of tumors originating from periosteum, especially of skull, orbits, nasal sinuses, ribs and vertebrae

Answer 10

chloroma

Question 11

a focal malignant tumor
composed of myeloblast or
early myeloid precursors
occurring outside of the
bone marrow

Answer 11

MYELOBLASTOMA

Question 12

cancer of plasma cells

Answer 12

myeloma

Question 13

proliferation of one of
the cell types of the
lymphopoietic reticular
tissue

Answer 13

lymphoma

Question 14

is a reactive but excessive leukocytosis
characterized by the presence of immature cells in the peripheral blood

increase in the total of leukocyte count in which
mimics leukemia

Answer 14

leukamoid reaction

Question 15

is a neoplastic clonal MPD that commonly manifests with panmyelosis in the bone marrow and increases in RBC, granulocytes, and platelets in the peripheral blood

Answer 15

polycythemia vera

Question 16

presence of JAK 2 (janus kinase 2)
 JAK 2 is associated with bone
marrow disorder caused by the
production of too many blood
cells

Answer 16

polycythemia vera

Question 17

treatment for polycythemia vera that prevents thrombosis

Answer 17

aspirin

Question 18

given to a px with high risk for polycythemia

Answer 18

hydroxyurea

Question 19

classified as a MPD in which the proliferation of an abnormal type of BM stem cell results in fibrosis, or the replacement of the marrow with collagenous connective tissue fibers

Answer 19

Myelofibrosis

Question 20

treatment for myelofibrosis

Answer 20

Androgen theraphy
› Prednisone
› Danazol
› Splenomegaly – hydroxyurea

Question 21

Characterized by autonomous proliferation of the
megakaryocytic cell lines.
 Thrombocytosis is present without a reactive
cause.

Answer 21

thrombocythemia

Question 22

treatment for thrombocytopenia

Answer 22

Busulfan in older patients
› Low dose aspirin to prevent thrombosis
› - Hydroxyurea theraphy

Question 23

a MPD arising as a clonal process from a
pluripotential stem cell
 begins with a chronic clinical phase that
progresses to an accelerated phase in 3 to 4 years and often terminates as an acute leukemia

Answer 23

chronic myelogenous leukemia

Question 24

a characteristic feature present in proliferating
hematopoietic cells is the Philadelphia chromosome
 has overproduction of myeloid cellulite that
results in preponderance of immature cells in the
neutrophilic line

Answer 24

chronic myelogenous leukemia

Question 25

Can mimic neutrophilic glucamoid reaction

Answer 25

chronic myelogenous leukemia

Question 26

treatment for chronic myelogenous leukemia

Answer 26

Busulfan › Bone marrow stem cell transplantation

Question 27

group of clonal disorder of neoplastic pluripotential stem cells characterized by a decrease in one or more types of peripheral blood cells due to abnormal maturation in the bone marrow

Answer 27

Myelodysplastic syndrome

Question 28

represent a group of neoplastic conditions originating from cells of the lymphoreticular system

Answer 28

LYMPHOPROLIFERATIVE DISORDERS

Question 29

composed of small B-lymphocytes with abundant cytoplasm and fine (hairy) cytoplasmic projections

Answer 29

HAIRY CELL LEUKEMIA

Question 30

also known as Alibert-Bazin syndrome  the most common form of cutaneous T-cell lymphoma  is a lymphoreticular neoplasm primarily involving the skin

Answer 30

MYCOSIS FUNGOIDES

Question 31

a malignant disorder characterized by painless, progressive enlargement of lymphoid tissue  Hallmark is a large binucleated or multinucleated cell with each nucleus bearing a very large nucleolus (Reed Sternberg Cell)

Answer 31

HODGKIN’S DISEASE

Question 32

Owl’s eye appearance or popcorn cells

Answer 32

Reed-strenberg cell

Question 33

Nodular lymphocyte-predominant Hodgkin lymphoma  is a B cell neoplasm composed of relatively rare neoplastic cells scattered within the nodules of reactive lymphocytes  no reed-sternberg cells

Answer 33

NONHODGKIN’S DISEASE

Question 34

other names: Plasmatocytoma, Kohler’s Disease  is a neoplasmic proliferation of morphologically abnormal plasma cells primarily occurring in the BM either in nodules or diffusely.

Answer 34

MULTIPLE MYELOMA

Question 35

is an uncommon condition which behaves as a slowly progressive lymphoma  is proliferation of cells which produce a monoclonal IgM paraprotein

Answer 35

WALDENSTROM’S MACROGLOBULINEMIA

Question 36

Other name: Glandular Fever, Pfeiffer’s Disease, Kissing Disease (commonly called)

Answer 36

INFECTIOUS MONONUCLEOSIS

Question 37

T cells reacting against B lymphocytes infected with Epstein-Barr (EB) virus

Answer 37

INFECTIOUS MONONUCLEOSIS

Question 38

represent a group of diseases with abnormal proliferation of mesenchymal cells that are closely related to phagocytic histiocytes and to fat cells  due to inborn errors in metabolism genetically transmitted

Answer 38

HISTIOCYTOSES/ STORAGE DISEASE

Question 39

is a collagen disease which affects women most commonly  characterized by skin rash, arthralgia, fever, renal, cardiac and vascular lesions, anemia, leukopenia, and thrombocytopenia

Answer 39

SYSTEMIC LUPUS ERYTHEMATOSUS

Question 40

3 TYPES OF ANTIBODY of SLE

Answer 40

Anti-DNP Anti-DNA Anti-Nuclear

Question 41

ACQUIRED IMMUNODEFICIENCY SYNDROME

Answer 41

a disorder secondary to an infection with the human immunodefficiency virus (HIV)

Question 42

a RNA retrovirus that is cytotropic for CD4 positive T cells and macrophages

Answer 42

HIV