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Blood & Screening Tests > Leukocyte Disorders # 2 > Flashcards

Leukocyte Disorders # 2 Flashcards

(56 cards)

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1
Q

Name the types of granulocytes

A

Neutrophils, Eosinophils, Basophils

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2
Q

Name the types of agranulocyes

A

Lymophocytes, Monocytes

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3
Q

*Define WBC count for leukocytosis

A

WBC count >11000/mm3

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4
Q

*Define WBC count for leukopenia

A

WBC count < 4000/mm3

infection risk

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5
Q

*What is the normal WBC count for adults?

A
  • African American Adults: 3,200-10,000 cells/mm3

- Adults: 4,500-10,500 cells/mm3

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6
Q

*Define WBC count for Neutrophilia

A

> 7000/mm3

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7
Q

*What is neutrophilia associated with

A

Pyogenic or bacterial infection

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8
Q

*Define WBC count for Neutropenia

A

< 1800/mm3

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9
Q

*What disorders are associated with eosinophilia?

A

Allergic reactions and parasitic disease

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10
Q

*Define WBC count for Eosinophilia

A

> 500 eosinophils/mm3

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11
Q

What disorders are associated with eosinopenia

A

Hypercortisolism & steroid therapy

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12
Q

*Define WBC count for eosinopenia

A

<50 eosinophils/mm3

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13
Q

*What disorder is associated with large irregular atypical lymphocytes?

A

Mononucleosis

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14
Q

*What do blast cells with aure rods indicate?

A

Acute myelogenous Leukemia (AML)

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15
Q

*What disorder do “smudge” or “basket” cells indicate?

A

Chronic Lymphocytic Leukemia (CLL)

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16
Q

*What do Reed Sternberg cells indicate (cells look like 2 owls eyes)?

A

Hodgkin Lymphoma

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17
Q

*What disorder does a Philadelphia chromosome indicate?

A

Chronic Myelogenous Leukemia (CML)

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18
Q

What disorder is leukocytosis linked to?

A

Leukemoid reaction and leukemia

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19
Q

What disorder is linked to leukopenia?

A

serious risk for infection

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20
Q
  • What percentage of WBCs do Polys or segs make up?
A

60% or 6000/mm2

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21
Q
  • What percentage of WBCs do Lymphocytes make up?
A

30% or 3000/mm3

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22
Q
  • What percentage of WBCs do monocytes make up?
A

5% or 500/mm3

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23
Q
  • What percentage of WBCs do Eosinophils make up?
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A

3% or 300/mm3

24
Q
  • What percentage of WBCs do Basophils make up?
Study These Flashcards
A

1% or 100/mm3

25
* What percentage of WBCs do band cells make up?
1% or 100/mm3
26
What is one main cause of neutropenia?
Splenic sequestration
27
Define agranulocytosis
Marked neutropenia and leukopenia | Neutrophil count < 500/mm3
28
*Define WBC count for Basophilia
> 50 basophils/mm3
29
What disorders are associated with Basophilia
- parasitic infestations - allergic reactions - chronic granulocytic leukemia
30
*Define WBC count for Basopenia
<20 basophils/mm3
31
What disorders are associated with Basopenia?
- acute infection - hyperthyroidism - steroid therapy
32
*Define WBC count for Monocytosis
>500 monocytes/mm3
33
What disorders are associated with Monocytosis?
- bacterial infections - Chronic TB - Symphilis - Subacute bacterial endocarditis
34
*Define WBC count for Monocytopenia
<100 monocytes/mm3
35
What disorders are associated with Monocytopenia
- steriod therapy | - HIV
36
*Define WBC count for Lymphocytosis
> 4000 lymphocytes/mm3
37
What disorders are associated with lymphocytosis
-viral infections
38
*Define WBC count for lymohopenia
< 1000 lymphocytes/mm3
39
What disorders are associated with lymphopenia?
- chemotherapy - steroid therapy - HIV
40
Where do B lymphocytes mature?
Bone Marrow
41
Where do T lymphocytes mature?
Thymus gland
42
What is the difference between B lymphocytes and T lymphoctes?
- B lymphocytes control specific antigen-antibody response "memory cells" - T lymphocytes involve cellular immunity
43
a) What is the normal CD4 range and | b) at which level do oportunistic infections present?
- NL 589-1505 | - Abn < 200
44
* What disorders are Dohle bodies found in?
- Infection/Inflammation - Burns - Pregnancy
45
What is a Pleger Huet cell anomaly?
- Benign dominant inherited defect of terminal neutrophil differentiation. - It is confused with a left shift b/c It can give rise to an increase in neutrophil band forms
46
What does a pseudo pleger-huet cell look like?
bi-lobed neutrophil with clumped chromatin
47
* What are the characteristics of Chediak-Higashi Anomaly?
- Recurrent infections - Albinism - Multiple neurologic abnormalities
48
What do WBCs of a pt. with Cehdiak-Higashi disease present with?
- Depressed neutrophil # - Giant cytoplasmic granules - Impaired chemotaxis, intracellular killing, and natural killer cell function of WBCs
49
Describe the type of cell that is associated with Lupus Erythematosus cell
LE cell with which a neutrophil has ingested nuclear material (nuclear debris)
50
*Which disorder does hypersegmented neutrophils indicate?
Myelodysplastic syndrome
51
* What disorder is associated with Lymphoblasts with no cytoplasmic ganules?
Acute lymphocytic Leukemia (ALL)
52
* What disorder is associated with Blast cells with Aure rods?
Acute Myelogenous Leukemia (AML)
53
*At what helper T lymphocye count is a person considered to haev AIDS?
<200/mm3
54
* What stain is used to differentiate between chronic granulocytic leukemia (CML) and leukemoid reactions?
Leukocyte Alkaline Phosphatase (LAP) stain
55
* What disorder presents with the Philidelphia Chromosome?
Chromic Myelogenous Leukemia (CML)
56
* What type of cells are linked to Hairy cell leukemia?
mononuclear cells with fried egg appearance

Blood & Screening Tests (10 decks)

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