Lewy Body dementia Flashcards
1
Q
Characteristic pathological feature of Lewy Body
A
alpha-synuclein cytoplasmic inclusions (Lewy bodies)
Found in the:
substantia nigra
paralimbic area
neocortical areas
2
Q
What percentage of patients with Alzheimers also have incidental Lewy Bodies?
A
40%
3
Q
Clinical features of lewy body dementia
A
- progressive cognitive impairment
- early impairments in attention and executive function
- parkinsonism
- visual hallucinations
4
Q
Diagnosis of lewy body is usually clinical, but what Imaging can be used?
A
DaT scan
5
Q
Management of lewy body dementia
A
Acetylcholinesterase inhibitors (e.g. donepezil, rivastigmine)
Memantine (NMDA receptor antagonist)
6
Q
Why should neuroleptics should be avoided in Lewy body dementia
A
patients are extremely sensitive and may develop irreversible parkinsonism
7
Q
A
