Lewy body dementia

Question 1

give the clinical features of Lewy body dementia

Answer 1

dementia
parkinsonism

fluctuating cognitive performance and level of consciousness

complex hallucinations

significant depressive episode

Question 2

where are lewy bodies commonly found

Answer 2

substantia nigra
paralimbic
neocortical

Question 3

what are Lewy bodies

Answer 3

alpha synuclein cytoplasmic inclusions

Question 4

what investigation can you do in suspected Lewy body dementia

Answer 4

single photon emission computed tomography (SPECT). DaT scan

Question 5

what should you NEVER give in Lewy body dementia

Answer 5

1st generation antipsychotic (haloperidol, chlorpromaize)

Question 6

give the drugs which harm Parkinson’s patients

Answer 6

Haloperidol
Antipsychotics
pRochlopromazine
Metoclopramide

Question 7

how do you manage mild-moderate disease

Answer 7

donepezil or rivastigmine 1st line

galantamine 2nd line

Question 8

how do you manage severe disease

Answer 8

donepezil or rivastigimine 1st line

memantine second line