Linger, final CIS antineoplastic agents Flashcards Preview

Year 2 Heme lymph > Linger, final CIS antineoplastic agents > Flashcards

Flashcards in Linger, final CIS antineoplastic agents Deck (14):
1

cyclophosphamide and ifosfamide urologic toxic metabolite responsible for hemorrhagic cystitis

acrolein

2

what rescues radiation induced xerostomia

amifostine

3

what is used for MTX rescue

tetrahydrogolic acid (leucovorin)

4

main reason for giving allopurinol prophylactically prior to starting course of chemo

reduce risk of hyperuricemia

5

which drug, with use of allopurinol, should be used with extra caution

mercaptopurine

6

34 HIV M with 6 mo Hx CD20+ DLBCL
chemo combination
current CD4 is 150 cells
which agent contraindicated

vinblastine

7

administration of what drug combo is best for eliminating HS reactions assoc with paclitaxel,
pretreat with what?

diphenhydramine and Dexamethasone

8

Chromosomal studies show t9:22
which most likely used in Tx?

imatinib

9

Tx for large soft tissue sarcoma resected from retroperitoneum recieving radiation and chemo
mesna and another drug is used
what is other drugs MOA?

alkylation of DNA

10

mesna is used to rescue actions of what

cyclophosphamide

11

MOA for drug of choice for HER2/neu breast carcinoma

inhibition Pi of R Tyrosine Kinase
trastuzumab

12

63 y.o female with metastatic colon cancer
overexpression EGFR
which agent most appropriate?

cetuximab

13

which agent is used to block interaction of VEGF

bevacizumab

14

aLL on cytarabine, vincristine, prednisone, aspariginase, allopurinol
difficulty with proprioception and has numbness in hands and feet. eyelid lag and ataxia. confusion?
cause of mental status?

asparaginase and cytarabine


vincristine is causing PNS neuropathy