hematopoiesis CIS, putthoff Flashcards Preview

Year 2 Heme lymph > hematopoiesis CIS, putthoff > Flashcards

Flashcards in hematopoiesis CIS, putthoff Deck (29):
1

granular lymphocytes

NK lymphoma

2

CML as leukemia is classified as what

myeloproliferative syndrome

3

where do platelets come from

myeloid cell lineage

4

early, significant life-threatening bleeding

acute promyelocytic leukemia M3 in AFB

5

translocation in APL

t15;17

6

CD56

NK

7

CD 3 and 5

B cell

8

CD45

all WBC
used to differentiate between lymphoreticular and carcinomas

9

CD11c

hairy cell leukemia

10

T cell markers

ALK, NOTCH1 mutations

11

BCL2, BCL6

diffuse large b cell lymphoma

12

CD30 CD34 CD11c

B cell markers
CD 30 can be + in anaplastic T cell lymphoma (ALK+)

13

C-MYC

Burkitt lymphoma

14

t14;18

C-myc

15

MYD 88

lymphoplasmacytic lymphoma

16

peroxidase and non-specific esterase activity is most likely discernible in
AML (Mo)
CML
ALL
CMML
CLL

peroxidase stains granulocytes
non-specific esterase stains monocytic
CMML

17

CML stains peroxidase or non-specific esterase?

peroxidase

18

what can progress to DLBCL

CLL
follicular lymphoma
T cell immunodeficiency assoc with EBV
marginal zone lymphoma
lymphoplasmacytic lymphoma

19

42 y.o F with Dx infiltrating ductal carcinoma and all 14 nodes examined show exuberante histiocytosis with intracell pigment depositions
consistent with?
metastatic infiltrating ductal carcinoma
reactive
metachronous lymphoma
histiocytosis X
tingible body anthracosis

Reactive
histiocytes have macrophages and dendritic cells

20

5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is still
most likley?
acute pyogenic infection
N meninginitis
acute leukemia
ALL
CML

Acute b cell leukemia

21

5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which if + is most useful in corroborating most likely Dx

terminal dinucleotide transferase

22

5 y.o M with lymphocytosis, low platelets and cyclic fevers head hurts and neck is stiff
peripheral blas count is 15%
which implies better prognosis

t 12;21

23

17 y.o M with high WBC and low platelet low Hct
peripheral blast is 25% and BM has 40% blast
recent fevers and weight loss
+ peroxidase and non-specific esterase
significant mucosal hemorrhage of gingica and circumoral areas
best Dx?
-myelodysplastic syndrome
-polycythemia vera
-AMML
-Acute T cell leukemia
CMML with blast crisis

AMML

24

45 y.o F with high WBC, left shift neutrophilia, eos and basophils
platelet is lower of normal
low grade fevers that coem and go
no organomegaly
history of SLE
what would be useful in categorizing acute syndrome?
-immunocytochemistry for peroxidase
-LAP
-non-specific esterase
- BCL 10
t(9;22)

LAP
leukocyte alkaline phosphatase
high if reactive
low if myeloid

25

52 y.o M generalized lymphadenopathy and splenomegaly
high WBC with lymphocytosis
platelet count 157,000 (norm)
spleen looks like follicular lymphoma
most likely is?
-T cell neoplasm
-hairy cell leukemia
-mature B cell neoplasm
-sezary syndrome
-diffuse large b cell lymphoma

mature B cell

26

52 y.o M generalized lymphadenopathy and splenomegaly
high WBC with lymphocytosis
platelet count 157,000 (norm)
spleen looks like follicular lymphoma
genetic analysis will most likely exhibit what
BCL2 -
c-MYC
EBV +
t 14;18
9;22

t14;18

27

17 y.o M irritable bowel syndrome for 6 mo and weight loss
lesions in ileum
biopsy from GI tract lesion shows starry sky
following is most likely
-BCL2
-EBV +
-c-MYC
-t14;18
-mucinous adenocarcinoma

c-MYC, burkitt

28

62 y.o F with unremarkable CBC
waldeyers ring has mass and responds to anti CD20
molecular profiling indicates dyregulation BCL6
most consistent with?
-hodgkins
-richter syndrome
-HTLV-1
-HHV8
-mature B cell neoplasm

a mature b cell neoplasm
diffuse large b cell lymphoma

29

57 y.o M with rigors fever and acute lobar pneumonia
lymphadenopathy and splenomegaly
nodules in small bowel
biospy looks like mantle cell lymphoma

lymphomatoid polyposis
CD5+, CD23-