Flashcards in Linkage Analysis-Mastick Deck (8)
To do linkage analysis, what are the 2 things you need to do?
genotype lots of family memebers
Haplotype pairs of alleles inherited together
What are used to detect polymorphisms?
RFLP, VNTR, Microsatellites, SNP (most used)
What kinds of tests are these?
- DNA microarrays,
- allele specific oligonucleotides (ASO),
- single-base extension sequencing,
What do you have to do with RFLP and VNTR tests?
utilized southern blots and PCR
Microsatellite tests use what?
Is hunington and Neurofibrosis 1 dominant or recessive?
Is PKU and Neurofibrosis 1 dominant or recessive?