Lipid Metabolism Flashcards
(23 cards)
lipids are:
a. soluble
b. insoluble
insoluble
what are lipids essential for (2)
synthesis of the membrane
maintenance of integrity of the membrane
lipids are _ sources
energy
lipids are precursors for
hormones and signalling molecules
how are non-polar lipids transported
in blood within lipoproteins
give 2 examples of lipoproteins
high density lipoprotein (HDL)
low density lipoprotein (LDL)
what two things is atherosclerosis associated with (in terms of lipoproteins)
elevated HDL
decreased LDL
what do lipoproteins consist of: (3)
- hydrophobic core
- hydrophilic coat
- apoproteins
what does the hydrophobic core of a lipoprotein consist of
- esterified cholesterol and - triacylglycerols (TAGs)
what does the hydrophobic coat consist of
monolayer of:
- amphipathic cholesterol
- phospholipids
- apoproteins (one or more)
what are the 4 major classes of lipoproteins
- HDL particles
- LDL particles
- VLDL particles (very-low density)
- chylomicrons
what apoproteins do HDL particles contain
- apoA-I
- apoA-II
what do apoproteins do LDL particles contain
apoB-100
what do apoproteins do VLDL particles contain
apoB-100
what do apoproteins do chylomicrons contain
apoB-48
what do apoB-containing lipoproteins do
deliver TAGs:
- to muscle for ATP biogenesis
- to adipocytes for storage
where are chylomicrons formed
intestinal cells
what do chylomicrons transport
dietary triglycerides
what pathway do chylomicrons use
exogenous pathway
where are VLDL formed
liver cells
what do VLDL transport
TAGs (synthesised by liver cells)
what pathway do VLDLs use
endogenous
what is a summary of apoB-containing liposomes
- assembly with apoB-100 in liver, apoB-48 in intestines
- intravascular metabolism (involving hydrolysis of TAG core)
- receptor mediated clearance
