Lipids

Question 1

predominant FA in coconut oil

Answer 1

lauric acid (12:0)

Question 2

end product of mammalian FA synthesis

Answer 2

palmitic acid (16:0)

Question 3

predominant FA in olive oli

Answer 3

18:1 (9)

Question 4

Essential FAs

Answer 4

linoleic acid (18:2) -9,12
linolenic acid (18:3) -9,12,15

Question 5

precursor of PG from linoleic acid

Answer 5

arachidonic (20:4)

Question 6

arachidonic acid derived from

Answer 6

linoleic acid

Question 7

RLS of lipogenesis

Answer 7

acetyl coA → malonyl coA

acetyl coA carboxylase

Question 8

RLS of beta oxidation

Answer 8

traslocation of FA from cytosol to mitochondria

carnitine palmitoyl transferase

Question 9

Net ATP yield of palmitate

Answer 9

106 ATPs

Question 10

MC inborn error of FA oxidation

Answer 10

Medium chain FA DH def

Question 11

peripheral neuropathy with ataxia, retinitis pigmentosa, abn in skin and bones
inc phytanic acid

Answer 11

Refsum dse

Question 12

cerebrohepatorenal syndrome
inc VLCFA
liver dysfunction, mental retardation, weakness, hypotonia , craniofacial dysmorphism

Answer 12

Zellweger syndrome

Question 13

inc VLCFA

neurodegeneration, adrenocortical insuff, hypogonadism

Answer 13

Adrenoleukodystrophy

Question 14

products of ketogenesis

Answer 14

acetoacetate
B-hydroxybutarate
acetone

Question 15

RLS of ketogenesis

Answer 15

acetoacetyl coA + acetyl coA → HMG coA reductase

Question 16

why is liver not able able to use ketone bodies

Answer 16

lacks the enzyme succinyl coA-acetoacetate-coA transferase

Question 17

cofactor of LCAT found in HDL

Answer 17

Apo A1

Question 18

mediates assembly and secretion of VLDL

structural protein of VLDL, IDL

Answer 18

Apo B 100

Question 19

main apoprotein and mediates secretion of chylomicrons from small intestines

Answer 19

chylomicrons

Question 20

cofactor of lipoprotein lipase

Answer 20

apo C II

Question 21

mediates uptake of chylomicron remnants and IDLs

Answer 21

Apo E

Question 22

type I hyperlipoproteinemia

Answer 22

familial LPL def

Question 23

type IIa hyperlipoproteinemia

Answer 23

familial hypercholesterolemia

defective LDL receptor

Question 24

type III hyperlipoproteinemia

Answer 24

familial dysbetalipoproteinemia

abnormal apoE

Question 25

type IV hyperlipoproteinemia

Answer 25

familial hypertriacylglycerolemia VLDL overproduction

Question 26

high TAG due to absence of apo CII leading to inactive LPL aterosclerosis in elderly d/t low or near absence of HDL

Answer 26

familial a-lipoprotein deficiency Tangier dse Fish eye dse Apo A1-deficiencies