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Lipids and Lipoprotein Flashcards

(85 cards)

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1
Q

Lipids are Commonly referred to as

A

Fats

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2
Q

Lipids is composed mainly of

A

C-H bonds

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3
Q

Considered primary source of fuel

A

Lipids

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4
Q

Lipids requires _____ for circulation in the blood

A

Lipoprotein

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5
Q

Linear of CH bonds that terminate with a carboxyl group

A

Fatty acids

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6
Q

Where does fatty acids mainly derived

A

Hydrolysis of TAG in adipose tissue

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7
Q

It is the most important source of energy

A

Fatty acids

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8
Q

Fatty acids are mostly bound to

A

Albumin

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9
Q

Building blocks of lipid

A

Fatty acids

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10
Q

TAG is also known as

A

Neutral fats

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11
Q

It contains 3 fatty acids attached to one molecule of glycerol

A

TAG

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12
Q

The main storage lipid in man

A

TAG

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13
Q

Similar structure to TAG except they only have 2 fatty acids

A

Phospholipids

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14
Q

Phospholipids are the constituent of

A

Cell membrane

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15
Q

3 forms of phospholipid

A

Lecithin: 70%
Sphingomyelin:20%
Cephalin: 10%

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16
Q

Only Phospholipid in membrane that is NOT derived from glycerol

A

Sphingomyelin

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17
Q

Sphingomyelin is associated with px suffetting from

A

Niemann- pick dsx

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18
Q

An unsaturated steriod alcohol containing 4 rings

A

Cholesterol

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19
Q

A hydrophilic part of the cholesterol

A

A-ring

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20
Q

Cholesterol is the precursor of

A

Steroid hormones and vitamin D

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21
Q

2 forms of cholet

A

Cholesterol ester: 70%
Free cholesterol: 30%

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22
Q

Catalyzes the esterification of cholesterol

A

LCAT

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23
Q

What organ synthesizes LCAT

A

Liver

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24
Q

Activsfor of LCAT

A

Apo- A1

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25
Enable _____ to accumulate cholesterol as cholesterol ester
HDL
26
Termed to liberate the cholesterol or break ester bond
Saponification
27
T or F: Cholesterol also served as a source of fuel
False ( do not serve, because it is not readily catabolized by most cell)
28
Surface of lipoprotein
Cholesterol and phospholipids
29
Core of lipoprotein
TAG and cholesteteryl ester
30
Main purpose of lipoprotein
To deliver the fuel to peripheral cell
31
Primarily located on the surface of lipoprotein particles
Apolipoprotein
32
Major location of apo a1 and apo a2
HDL
33
Major location of apo b-100
LDL and VLDL
34
Major locatof apo b48
Chylomicrons
35
Major location of apo (a)
Lp (a)
36
Major location of apo e
VLDL and HDL
37
Major location of apo A4, C1-3
Chylomicrons, VLDL, and HDL
38
Largest and the least dense lipoprotein
Chylomicrons
39
Role of chylomicrons
Delivery of dietary fats to hepatic and peripheral cells
40
Appearance of chylomicrons
White creamy
41
Major carrier of ENDOGENOUS tag and transfer tag
VLDL
42
VLDL is also known as
Pre beta lipoprotein
43
Also knows as beta lipoprotein
LDL
44
Considered bad cholesterol
LDL
45
Increased LDL meanz
Increased risk of atherosclerosis and CHD
46
Considered as good cholesterol
HDL
47
HDL is also known as
Alpha lipoprotein
48
Smallest and most dense lipoprotein
HDL
49
HDL has
Anti-atherogenic property
50
Reverse cholesterol transport
HDL
51
Minor lipoprotein
Lp (a) IDL
52
Lp (a) is also lnowtas
Sinkingg pre b lp
53
Ldl like particle that contain 1 molecule of apo(a)
Lp (a)
54
Abnormal lipoprotein
Lp (x) Beta-VLDL
55
T or F: LpX is rich in lipids
True
56
LpX is found in
Obstructive jaundice and LCAT deficiency
57
Beta VLDL is also known as
Floating beta lp
58
Beta vldl accumulates
Type 3 hyperlipoproteinemia
59
Dsx associated with abnormal lipid concentration
Dyslipidemias
60
Used to describe indiv for whome the cause of hypercholesterolemia is likely multifactorial
Polygenic (non familial) hypercholesterolemia
61
Caused by defective or deficient LDL- receptor gene on chromosome 19
Famial hypercholesterolemia
62
Familial hypercholesterolemia causes
High LDL
63
Accumulation of plasma beta vldl rich in cholesterol and chylomicron remnants
Familial dysbetalipoproteinemia
64
Familial dysbetalipoproteinemia is also known as
Type 3 hyperlipoproteinemia
65
During ultracentrifugation, Familial dysbetalipoproteinemia is high in
VLDL
66
During electrophoresis, Familial dysbetalipoproteinemia is high in
LDL
67
Phytosterol are absorbed and accumulate in plasma and peripheral tissue
Sitosterolemia
68
Due to defective apo B synthesis
Abetalipoproteinemia
69
Abetalipoproteinemia is also known as
Bassen-Kornzweig Syndrome
70
Abetalipoproteinemia is associated with
Defects in absorption in Fat-soluble vitamin AEK
71
Due to apo b deficiency resulting from point mutation in apo b
Hypobetalipoproteinemia
72
Complete absence of HDL due to mutation in the ABCA1 gene on chromosome 9
Tangier's dsx
73
Fish eye disease
LCAT deficiency
74
Inability to clear chylomicrons
Lipoprotein lipase deficiency
75
Too many chylomicrons in circulation
Chylomicron retention dsx
76
Chylomicron retention dsx is also known as
Anderson's dsx
77
Preferred spx for lp assay
EDTA plasma
78
Fasting needed for lipids and lipoprotein
12-14 hrs
79
End product of Liebermann Burchardt rxt
Cholestadienyl monosulfic acid
80
End color of Liebermann Burchardt rxt
Green
81
End product of salkowski rxt
Cholestadienyl disulfic acid
82
End color of salkowski rxt
Red
83
Chemical method of cjolt
salkowski rxt Lieberman Burchardt rxt
84
Reference method fro quantification of lp
Ultracentrifugation method
85
Most commonly used support medium
Agarose gel

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