Lipids and Lipoproteins Flashcards Preview

Chemical Pathology > Lipids and Lipoproteins > Flashcards

Flashcards in Lipids and Lipoproteins Deck (13)
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1

What forms cholesterol?

Acetyl CoA

2

What is the critical step in the production of cholesterol?

Critical step is the production of mevalonate by HMG CoA reductase.

3

How is cholesterol transported?

Cholesterol is not soluble in plasma and is transported in lipoproteins.

4

Arrange the lipoproteins from smallest/most dense to largest/least dense.

HDL
LDL
IDL
VLDL
Chylomicrons

5

What do all lipoproteins contain?

TGs, cholesterol, cholesterol esters, phospholipids and apoproteins

6

State the function of HDL.

Reverses cholesterol transport
Protects against atherosclerosis
Carries 20-30% of TGs to liver

7

State the function of LDL.

Most atherogenic
Carries 60-70% of TGs.
Carries cholesterol to tissues

8

State the function of IDL.

Intermediated from LDL to VDL

9

State the function of VLDL.

Transports endogenous TAG to tissue.
Precursor to IDL and LDL

10

What is the function of chylomicrons?

Transport FA and cholesterol from diet to tissues

11

Describe how the exogenous lipid cycle occurs.

Dietary fat that is absorbed in the intestine is packaged into chylomicrons as TAGs.
Chylomicrons then circulate and deliver dietary TAGs throughout the body.

12

How are TAGS released from chylomicrons in the exogenous pathway?

TAGs are released by lipoprotein lipase (LPL)

13

Where is LPL found?

Found in capillaries of tissues within the body (most importantly within adipose)