Lipids V Flashcards
What is the function of hormone sensitive lipase?
to release free fatty acids into circulation from stored triglycerides
What is the effect of insulin on HSL?
Insulin inhibits the activity of HSL
What is the effect of cortisol on HSL?
cortisol activates HSL
What is the effect of glucagon on HSL?
glucagon stimulates HSL from its effects on cAMP/PKA
What protein transports FFAs around the blood?
albumin
What class of apoproteins activate LCAT?
A class.
What is the significance of activating LCAT?
Apoproteins of the A class are able to extract lipids from cell membranes and transfer them to the hydrophobic core of lipoprotein particles
What is the function of B class apoproteins?
interact with lipoprotein receptors and mediate the uptake of the particle into cells
What is the function of C class apoproteins?
to modulate the function of lipoprotein lipase
What is the function of class E apoproteins?
removal of lipid-depleted lipoproteins from circulation
bind to receptors and initiate receptor mediated endocytosis
Where are chylomicrons secreted to after their synthesis?
thoracic duct
What are the main constituents of the chylomicron?
dietary fats and cholesterol
What is the function of chylomicrons?
distribution of dietary lipids through the body
What type of receptor do ApoB48 and ApoE bind to?
LDL receptor
What is the function of VLDLs?
distribution of ENDOGENOUSLY made lipids to peripheral tissues
Where are VLDLs manufactured?
liver
VLDLs are synthesized around what core apoprotein?
ApoB100
What apoproteins do VLDLs absorb upon their secretion?
ApoC and ApoE
What type of cells take up LDLs?
cells with a cholesterol demand
What apoprotein is critical for receptor mediated endocytosis?
ApoE
What is the function of HDLs?
to transport cholesterol from peripheral tissues back to the liver
Can humans break down cholesterol?
No. It must be excreted by the liver.
Where are HDLs synthesized?
the liver
What enzyme is responsible for attaching cholesterol to HDL?
LCAT
