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Liver Function Test Flashcards

1
Q

it is the CHIEF metabolic organ of the body?

A

liver

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2
Q

how mL of blood does liver RECEIVED per minute

A

15 mL

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3
Q

FUNCTIONS OF THE KIDNEY

A
  1. Synthetic function
  2. Conjugation function
  3. Detoxification and Drug metabolism
  4. Excretory and Secretory function
  5. Storage function
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4
Q

how many grams of ALBUMIN does a normal liver PRODUCE daily?

A

12 grams

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5
Q

how many BILIRUBIN is PRODUCED daily of a healthy adult?

A

200 - 300 mg

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6
Q

it is important for assessing NUTRITIONAL STATUS and presence of severe diseases involving LIVER, KIDNEY and BONE MARROW

A

total protein

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7
Q

Tests measuring the HEPATIC SYNTHETIC FUNCTION

A
  1. TOTAL PROTEIN
  2. PROTHROMBIN TIME

ALBUMIN

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8
Q

total protein Reference method but not routinely used

A

kjeldahl method

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9
Q

TOTAL PROTEIN

most widely used protein

A

biuret method

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10
Q

TOTAL PROTEIN

it has the HIGHEST ANALYTICAL SENSITIVITY

A

FOLIN CLOCALTEU (LOWRY) METHOD

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11
Q

TOTAL PROTEIN

reagent used in kjeldahl method

A

h2so4 (digesting agent)

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12
Q

TOTAL PROTEIN

reagent used in biuret method

A
  1. alkaline copper sulfate
  2. rochelle salt (NaK tartrate)
  3. NaOH and Potassium iodide
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13
Q

TOTAL PROTEIN

reagent used in folin clocalteu (lowry) method

A

phosphotungstic molybdic acid or phenol reagent

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14
Q

it is based on measurement of nitrogen content of protein

a. biuret method
b. folin clocalteu method
c. kjeldahl method

A

it is based on measurement of nitrogen content of protein

c. kjeldahl method

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15
Q

what is the equivalent 1 gram nitrogen to proteins?

a. 2.34 g
b. 6.54 g
c. 6. 64 g

A

what is the equivalent 1 gram nitrogen to proteins?

c. 6.54 g

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16
Q

end product of kjeldahl method?

A

ammonia

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17
Q

proteins absorbs light at what nm?

A

210 nm an 280 nm

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18
Q

migration of charged particles in an ELECTRIC FIELD

A

serum protein electrophoresis

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19
Q

Rheumatoid arthritis and malignancy would result to polyclonal gammopathy classified as?

A

chronic inflammation

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20
Q

the presence of SMALL SPIKES in BETA REGION is due to?

A

iron deficiency anemia

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21
Q

reagent used in SALT FRACTIONATION

A

SODUIM SULFATE SALT

22
Q

alternative test to chemical analysis of serum total proteins

a. spe
b. refractometry
c. salt fractionation

A

alternative test to chemical analysis of serum total proteins

b. refractometry

23
Q

globulin is insoluble in water but NOT in___________?’

a. dilute salt solution
b. sodium picric acid
c. NSS

A

globulin is insoluble in water but NOT in___________?’

a. dilute salt solution

24
Q

it is detection of proteins as little as 1ug

a. nihydrin
b. refractometry
c. coomassie brilliant blue dye

A

it is detection of proteins as little as 1ug

c. coomassie brilliant blue dye

25
it is widely used for detection of peptides and amino acids after paper chromatography
nihydrin
26
increased total protein, EXCEPT A. malignancy B. hepatic cirrhosis C. multiple myeloma d. walderstrom's macroglobulinemia
increased total protein, EXCEPT B. hepatic cirrhosis
27
in ACUTE VIRAL or TOXIC HEPATITIS prolonged protime signifies?
massive cellular damage
28
Low Total Protein + Low Albumin = a. hepatic cirrhosis b. nephrotic syndrome c. both
Low Total Protein + Low Albumin = | c. both hepatic cirrhosis and nephrotic syndrome
29
DYES used for the measurement of albumin
1. Bromcresol Green 2. Methyl Orange (MO) 3. Hydroxyazobenzene Benzoic acid ( HABA) 4. Bromcresol Purple
30
MOST COMMON USED DYE in measurement of albumin
bromcresol Green c = g
31
MOST SPECIFIC USED DYE in measurement of albumin
BROMCRESOL PURPLE sPecific = PurPle
32
it is a dye can be used in automated analyzers for determining serum albumin in parallel with Biuret reagent of total protein a. bcg b. bcp c. haba d. mo
bcg g= gamit na gamit heehehe
33
- IT IS ASSOCIATED WITH EXCESS AMOUNT OF THERAPEUTIC DRUGS IN SERUM - IT IS THE PRESENCE OF ALBUMIN WITH UNUSUAL MOLECULAR CHARACTERISTICS IN THE BLOOD A. analbuninemia B. bisalbinunemia
b. bisalbinunemia
34
if GLOBULIN is GREATER THAN albumin it is called INVERTED A/G RATION it is seen in
1. Cirrhosis 2. Multiple Myeloma 3. Walderstorm's macroglobilenemia
35
it is the end product of hemoglobin metabolism
bilirubin
36
it is formed from destruction of heme containing proteins such as myoglobin, catalase and cytochrome oxidase
bilirubin
37
formula of delta bilirubin
tb - db + id = db
38
CAUSE: failure of the bile to flow to the intestine/impaired bilirubin excretion a. pre hepatic jaundice b. post hepatic jaundice c. hepatocellular combined jaundice
CAUSE: failure of the bile to flow to the intestine/impaired bilirubin excretion b. post hepatic jaundice
39
Bilirubin TRANSPORT deficit a. Gilbert's syndrome b. Crigler- Najjar syndrome c. Dubin Johnson syndrome
Bilirubin TRANSPORT deficit a. Gilbert's syndrome
40
what are the methods of bilirubin assay
1. Evelyn and Malloy Method | 2. Jendrassik and Grof
41
VAN DE BERG REACTION is diazotization of bilirubin to produce azobilirubun a. Bilirubin assay b. BSP dye excretion test
VAN DE BERG REACTION is diazotization of bilirubin to produce azobilirubun a. Bilirubin assay
42
BUFFER for jendrassik and grof?
sodium acetate
43
coupling accelerator for evelyn and malloy method?
methanol
44
Terminates the initial reaction in jendrassik and grof and destroys the excess diazo reagent? a. sodium acetate b. ascorbic acid c. caffein sodium benzoate
Terminates the initial reaction in jendrassik and grof and destroys the excess diazo reagent? b. ascorbic acid
45
colorless end product of bilirubin metabolism
urobilinogen
46
what are the specimen in urobilinogen?
1. 2hr freshly collected urine | 2. freshly collected stool
47
method for urobilinogen
Ehrlich's method (p-dimethyl aminobenzaldehyde reagent)
48
what are the test for DETOXIFICATION FUNCTION?
1. Enzyme Tests | 2. Ammonia
49
enzymes secreted in liver
G gt O ct LD ALP LAP AMINOTRANSFERASES 5 NUCLEOTIDASE liver is mahal so meaning its GOLD mapapaisip ka nalang san ka kukuha nang ganon mapapatitig ka nalang sa ALAPAAP. tas tandaan nalang ung 5 nucleotidase
50
is is released from METABOLIC REACTIONS that occur in skeletal muscle during exercise
ammonia
51
preferred specimen in AMMONIA a. arterial blood b. venous blood
preferred specimen in AMMONIA a. arterial blood
52
common methods for Ammonia a. erhlich's method b. kjehdahl method and biuret method c. berthelot and glutamate dehydrogenase
common methods for Ammonia c. berthelot and glutamate dehydrogenase

Clinical Chemistry (4 decks)

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