Local Anasthetics

Question 1

What are local anasthetics

Answer 1

This are drugs given to the body to make it loose sensation

Make it numb

Question 2

Local anasthetics mechanism of action

Answer 2

They work by reducing the permeability of NA+ (sodium ion) in nerves

There by inhibiting depolarization and generation of action potential

Question 3

The structure of local anasthetics

Answer 3

They are hydrophilic secondary or tertiary amine linked to a lipohillic aromatic compound by an ester bond or amide bond

Question 4

Local anasthetics with amide bond include

Answer 4

Lidocaine
Prilocaine
Etidocaine
Buvivacaine

Question 5

Anasthetics with ester bond include

Answer 5

Cocaine
Procaine
Chloroprocaine
Tetracaine

Question 6

Difference between amide anasthetics and ester anasthetics

Answer 6

Amide anasthetics last longer and are not broken down by plasma cholinesterase

Ester anasthetics don’t last long because they are easily attacked by cholinesterase

Question 7

Spinal anasthetics is given to what mater

Answer 7

Arachnoid mater