Lupus

Question 1

Deposition of antigen-antibody complexes along vascular and tissue basement membranes.

Answer 1

SLE

Question 2

What is the ratio of the incidence of lupus in women compared to men?

Answer 2

9:1 (more common in women btw 20-40)

Question 3

Chromosome most often involved with lupus

Answer 3

chromosome 6

Question 4

What cells of the immune system are involved with the hyperactivity reaction of lupus?

Answer 4

B-lymphocytes

Question 5

What type of autoimmune reaction is lupus characterized as?

Answer 5

type III (caused by antibody-immune complex formation)

Question 6

Common initial presenting symptoms of lupus

Answer 6

butterfly rash, discoid lesions, photosensitivity, and oral/genital/nasal ulcers

Question 7

What is the difference between the polyarthritis of RA and Lupus?

Answer 7

In lupus polyarthritis is symmetrical, but unlike RA does not involve articular destruction

Question 8

Renal features associated with SLE

Answer 8

glomerulonephritis, nephrotic syndrome, and HTN

Question 9

Feature of lupus that presents with nonproductive cought, dyspnea, hypoxemia

Answer 9

Transient basilar pneumonic infiltrates (“lupus pneumonitis”)

Question 10

Cardiac feature of SLE characterized by tachycardia, ventricular arrhythmia, conduction problems, CHF/cardiomyopathy

Answer 10

myocarditis

Question 11

Surface vegetations on valves due to aggregation of platelets

Answer 11

Libman-Sacks endocarditis

Question 12

Palpable purpuric lesion on the shins in a patient with lupus and necrotizing vasculitis of the skin, kidney, brain

Answer 12

lupus vasculitis

Question 13

Manifested by reddish-cyanotic, reticular pattern of the skin that results in ulcer formation

Answer 13

livedo reticularis

Question 14

Increased GI tract condition with SLE

Answer 14

primary biliary cirrhosis

Question 15

Most common cause of death in early active SLE

Answer 15

Infectious complications related to active SLE and immunosuppressive treatment

Question 16

What causes the prolonged PTT of SLE?

Answer 16

antiphospholipid antibodies

Question 17

Primarily musculoskeletal, pulmonary, and polyserositic symptoms. No hypocomplementemia. Anti-nuclear antibodies present, but return to normal with withdrawal of drug

Answer 17

Drug Induced Lupus Syndromes

Question 18

Most common culprits for drug induced lupus syndromes

Answer 18

Procainamide and hydralazine

Question 19

Chronic cutaneous lupus
Involves plaque-like lesions of head, scalp and neck. First appear as red, swollen patches or skin. Later scarring, depigmentation, plugging of hair follicles.

Answer 19

discoid lupus