Lutheran, Lewis, Ii

Question 1

Lutheran Blood Group

Answer 1

Lua, Lub, Lu alleles
Antigens poorly developed at birth
Lu3 is common antigen

Question 2

Lu(a-b-) Phenotype

Answer 2

Recessive: inherit two Lu genes
ln(Lu): dominant inhibitor inherited independently of Lutheran
X linked: similar to ln(Lu)

Question 3

Lutheran Antibodies

Answer 3

Anti-Lua: non-RBC immune, aggultination is loose MF
Anti-Lub: IgG, RBC immune, mild HDFN and HTR
Anti-Lu3: inseperable anti-Lua and Lub, found in Lu null phenotype

Question 4

Lewis System

Answer 4

Le and le codominant
Antigens are not synthesized by the RBC, are passively adsorbed onto the membrane from the plasma
Le gene enzyme adds Fucose type I chain in secretions

Question 5

Lewis Antibodies

Answer 5

Anti-Leb: can demonstrate ABO specificity
Anti-LebH: reacts best with Leb positive red cells with highest amount of H
Anti-LebL: reacts equally with the Leb antigen on red cells of all ABO phenotypes

Question 6

Ii Blood Group

Answer 6

I gene codes for branching of i antigen (type 2 chain precursor)
I and I antigen sites are incomplete ABH active chains
High frequency antigens

Question 7

Adult i (iadult) Phenotype

Answer 7

Mutation specific for I antigen synthesis in red cells

Make anti-I

Question 8

Anti-I Antibodies

Answer 8

Non RBC immune, common autoantibody

Seen in iadult phenotype

Question 9

Anti-i Antibodies

Answer 9

React preferably with cord cells
Non-RBC immune, IgM
Can be found secondary to infectious mono

Question 10

Pathologic Anti-I

Answer 10

Wide thermal range of reactivity, good complement activator and high titer
Can be caused by Mycoplasma pneumonia infection

Question 11

Anti-IH

Answer 11

Found in the serum of A1 phenotype

Reacts strongly with RBCs high in H as well as I antigens