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Heme Week 2 > Lymphoid Disorders I > Flashcards

Lymphoid Disorders I Flashcards

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1
Q

In flow cytometry, cells are incubated with antibodies to bind these

A

Specific surface markers

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2
Q

This malignancy produces non-tender, firm, lymphadenopathy

A

Lymphoma

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3
Q

This is a very rare form of lymphoma that is associated with EBV infection

A

Extranodal NK/T cell lymphoma, nasal type

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4
Q

Extranodal NK/T cell lymphoma, nasal type is associated with this

A

EBV infection

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5
Q

“Lethal midline destructive lesion” refers to this type of lymphoma

A

Extranodal NK/T cell lymphoma, nasal type

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6
Q

Is Extranodal NK/T cell lymphoma, nasal type indolent or aggressive?

A

Very aggressive, but now with 50% 5 year survival with treatment

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7
Q

This virus is associated with diffuse large B C-cell lymphoma, primary CNS lymphoma, Hodgkin’s lymphoma

A

HIV

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8
Q

This virus is associated with adult T cell leukemia/lymphoma

A

HTLV

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9
Q

This virus is associated with Burkitt’s, post-transplant, HIV-associated, primary CNS, extranodal NK/T cell lymphoma (nasal type), Hodgkin’s

A

EBV

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10
Q

This virus is associated with splenic marginal zone lymphoma

A

Hepatitis C

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11
Q

This bacteria is associated with ocular MALToma/MZL

A

Chlamydia psittaci

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12
Q

This bacteria is associated with gastric MALToma/MZL

A

H. pylori

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13
Q

This type of biopsy is best for diagnosis of lymphoma

A

Excisional biopsy

core biopsy usually not adequate

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14
Q

This is a low grade B cell lymphoid malignancy of peripheral blood/marrow and lymph node involvement

A

Chronic lymphocytic leukemia / small lymphocytic lymphoma

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15
Q

This is the most common adult leukemia
Mean age 60 years

A

Chronic lymphocytic leukemia

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16
Q

What causes anemia or thrombocytopenia in Chronic lymphocytic leukemia / small lymphocytic lymphoma?

A

Marrow infiltration

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17
Q

This is the characteristic immunophenotype in Chronic lymphocytic leukemia / small lymphocytic lymphoma

A

CD20+/CD5+ and CD23+

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18
Q

What is the main presenting feature of Chronic lymphocytic leukemia / small lymphocytic lymphoma?

A

Lymphocytosis >5000/ul

must be monoclonal; kappa or lambda

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19
Q

Morphology of this condition will show small, mature appearing lymphocytes, with smudged chromatin; smudge cells

A

Chronic lymphocytic leukemia / small lymphocytic lymphoma

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20
Q

“snickerdoodle cookies” morphology of lymphocytes is seen in this condition

A

Chronic lymphocytic leukemia / small lymphocytic lymphoma

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21
Q

A lymph node biopsy in this condition will show diffuse population of small mature lymphocytes, and proliferation centers with pale staining due to larger activated cells

A

Chronic lymphocytic leukemia / small lymphocytic lymphoma

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22
Q

Chronic lymphocytic leukemia / small lymphocytic lymphoma is associated with this, leading to higher risk of infections

A

Hypogammaglobulinemia

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23
Q

Patients with Chronic lymphocytic leukemia / small lymphocytic lymphoma may have this type of anemia

A

Autoimmune hemolytic anemia

DAT (Coombs) positive; high LDH; splenomegaly

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24
Q

Occasionally, Chronic lymphocytic leukemia / small lymphocytic lymphoma can evolve to a more aggressive form, usually Diffuse large B cell lymphoma. This process is referred to as this

A

Richter’s transformation

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25
A patient with Chronic lymphocytic leukemia / small lymphocytic lymphoma who has a sudden increase in WBC count, and sudden increase in lymphadenopathy, may have this process occurring
Richter's transformation is evolving to a more aggressive form
26
This is a clonal neoplasm of small mature lymphocytes with cyclin D1 overexpression Mean age 65 years; more common in men
Mantle cell lymphoma
27
Mantle cell lymphoma is more common in men or women?
Men
28
Lymphadenopathy or splenomegaly are common in this neoplasm, which may have peripheral blood involvement and is more aggressive than CLL/SLL
Mantle cell lymphoma
29
Mantle cell lymphoma is defined by this genetic abnormality
t(11,14) with IgH-cyclin D1 fusion
30
This condition is defined by t(11,14) with IgH-cyclin D1 fusion
Mantle cell lymphoma
31
In Mantle cell lymphoma, t(11,14) forms this fusion protein
IgH-cyclin D1 Cyclin D1 amplified in malignant cells
32
Mantle cell lymphoma results in this molecule being amplified in malignant cells
Cyclin C1
33
This is the immunophenotype in Mantle cell lymphoma
CD20/CD5+ CD23-
34
This neoplasm has the following immunophenotype: CD20+/CD5+ and CD23+
Chronic lymphocytic leukemia / Small lymphocytic lymphoma
35
This neoplasm has the following immunophenotype: CD20/CD5+ and CD23-
Mantle cell lymphoma
36
This neoplasm is a clonal proliferation of follicle center cells with bcl2 amplification
Follicular lymphoma
37
Follicular lymphoma is a clonal proliferation of follicle center cells with this amplification
bcl2
38
This is the most common non-Hodgkin lymphoma
Follicular lymphoma
39
Lymph node biopsy shows follicles without germinal centers (back to back follicles), with monomorphic small cleaved cells, in this condition
Follicular lymphoma
40
This is the genetic abnormality in Follicular lymphoma
t(14;18) IGH with bcl2 Others with bcl2 amplification
41
This neoplasm has the following immunophenotype: CD20+ CD10+ CD5- bcl2+
Follicular lymphoma
42
This is a monoclonal neoplasm of marginal zone lymphocytes, often of MALT
Marginal zone lymphoma
43
Marginal zone lymphoma often arises due to this
Chronic inflammation H. pylori gastritis Hashimoto's thryoiditis Sjogrens sialadenitis
44
This is the genetic abnormality in Marginal zone lymphoma, gastric MALToma
t(11;18)
45
This is an indolent low grade B cell lymphoma that may spontaneously regress if antigenic stimulation cases
Marginal zone lymphoma
46
This is a high grade lymphoma of B cell lineage that may arise from lower grade lymphoma, but usually de novo origin Most common extranodal lymphoma
Diffuse large B cell lymphoma
47
This neoplasm may present as a rapidly enlarging mass, rare for peripheral blood or marrow involvement, rapidly fatal without treatment but common to cure with treatment
Diffuse large B cell lymphoma
48
Does Diffuse large B cell lymphoma have a good prognosis?
With treatment yes - common to cure with treatment Rapidly fatal without treatment
49
Diffuse large B cell lymphoma frequently affects these sites
Extranodal sites: CNS, effusions, bowel Not uncommon to be regional lymphadenopathy
50
This is a high grade B cell lymphoma with Myc amplification
Burkitt lymphoma
51
Burkitt lymphoma is a high grade B cell lymphoma with this amplification
Myc
52
Burkitt lymphoma is associated with this
EBV integration
53
This is the fastest growing tumor of humans 100% in cell cycle Pediatrics and adults
Burkitt lymphoma
54
These are three possible translocations that can cause Burkitt lymphoma
t(8,14) t(2,8) t(8,22)
55
t(8,14), t(2,8) and t(8,22) can cause this neoplasm
Burkitt lymphoma
56
Pediatric Burkitt lymphoma is endemic in Africa, and most commonly affects this site
Jaw 100% EBV
57
Pediatric Burkitt lymphoma is usually sporadic in the US, and affects these sites of the body
Abdomen, soft tissue, colon
58
Adults with Burkitt lymphoma is frequently with this
AIDS
59
Morphology shows starry sky pattern in this neoplasm
Burkitt lymphoma
60
Burkitt lymphoma produces a "starry sky" pattern. What is the stars?
Macrophages
61
Burkitt lymphoma produces a "starry sky" pattern. What is the sky?
B cells
62
This is a malignant neoplasm of CD4 T cells, associated with HTLV
Adult T cell lymphoma/leukemia
63
Adult T cell lymphoma/leukemia is a malignant tumor of this type of T cell
CD4
64
Adult T cell lymphoma/leukemia is associated with this
HTLV
65
Does Adult T cell lymphoma/leukemia have a good prognosis?
No Rapidly progressive, fatal disease
66
This neoplasm can cause skin lesions, lymphadenopathy often with bone involvement, and hypercalcemia Malignant cells with cloverleaf appearance
Adult T cell lymphoma/leukemia
67
Adult T cell lymphoma/leukemia will produce malignant cells with this appearance
Cloverleaf
68
This is a unique lymphoma of mature B cells in inflammatory background
Hodgkin lymphoma
69
Does Hodgkin lymphoma have a low or high cure rate?
High, >85%
70
What age groups present with Hodgkin lymphoma?
Bimodal ages: teen-20s and >65 years
71
Hodgkin lymphoma is related to this
EBV infection younger patients especially; lower SES
72
Frequent B symptoms, non-tender lymphadenopathy that is contiguous is characteristic of this condition
Hodgkin lymphoma
73
Pathogenesis of this neoplasm is the development of mature B cells which have lost most B cell markers
Hodgkin lymphoma
74
This is the neoplastic cell seen in Hodgkin lymphoma
Reed-Sternberg cell CD15+, CD30+, CD45-, Pax5+
75
Reed-Sternger cell is seen in this neoplasm Is CD15+, CD30+, CD45-, and Pax5+
Hodgkin lymphoma
76
Reed-Sternberg cells in Hodgkin lymphoma have this immunophenotype
CD15+ CD30+ CD45- Pax5+
77
Morphology of this neoplasm will have a background of mixed inflammatory cells, and cells often look like those in CMV infection - with owls eye appearance, binucleated, giant nuclei
Hodgkin lymphoma
78
Does Hodgkin lymphoma that is lymphocytic rich or lymphocytic depleted have a better prognosis?
Lymphocyte rich has relatively few neoplastic Reed-Sternberg cells
79
This form of Hodgkin lymphoma is a similar but different disease, with neoplastic cells in nodules of lymphocytes
Nodular lymphocytic predominant Hodgkin lymphoma
80
This neoplasm produces lymphocyte/histiocytic cell that is describes as a "popcorn cell"
Lymphocyte predominant Hodgkin lymphoma
81
Lymphocyte predominant Hodgkin lymphoma neoplastic cells will have this immunophenotype
CD20+ CD15- CD30- CD45+
82
This form of Hodgkin lymphoma is a longer disease course with frequent relapses; still excellent outcome
Lymphocyte predominant Hodgkin lymphoma
83
This stage of Hodgkin lymphoma involves a single lymph node region
I
84
This stage of Hodgkin lymphoma involves >2 lymph node regions
II
85
This stage of Hodgkin lymphoma involves lymph node regions on both side of diaphragm
III
86
This stage of Hodgkin lymphoma has visceral organ involvement
IV

Heme Week 2 (7 decks)

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