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Exam 5 > Lymphoid Neoplasms > Flashcards

Lymphoid Neoplasms Flashcards

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1
Q

Neoplastic population of immature lymphocytes (blasts).

A

Lymphoblastic leukemia/lymphoma

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2
Q

Usually leukemia (BM and blood)

A

B-ALL

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3
Q

Usually lymphomic mediastinal mass

A

T-ALL

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4
Q

Most ALLs are of ___________ lineage

A

B cell

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5
Q

Most common cancer of children

A

Lymphoblastic leukemia/lymphoma

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6
Q

Incidence of pre-B ALL highest at age _____

A

4

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7
Q

Incidence of pre-T ALL highest ________

A

in adolescence

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8
Q

Abrupt stormy onset. Bone pain in kids. Hepatosplenomegaly.

A

Lymphoblastic leukemia/lymphoma

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9
Q

“hand mirror”

A

Lymphoblastic leukemia/lymphoma

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10
Q

TdT, CD19, CD10, CD79a, cCD3, surface light chain negative

A

Lymphoblastic leukemia/lymphoma

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11
Q

hyperdiploidy
t(9;22)
t(12;21)

A

Good prognosis PreB ALL

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12
Q

t(v;11q23)

MLL gene

A

Poor prognosis PreB ALL

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13
Q

Translocations involving TCR on chr 7 and 14

A

Pre T ALL

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14
Q

Complete remission 95% kids and 60-85% adults

A

ALLs

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15
Q

Less than 2, adolescent or adult presentation. High peripheral blast count. Unfavorable cytogenetics. Minimal residual disease after treatment. t(v;11q23)

A

Poor risk factors ALL

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16
Q

Ages 2-10. Low WBC count. Early Pre-B phenotype (CD19/CD10). Favorable cytogenetics.

A

Favorable prognostic factors

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17
Q

CLL/SLL

A

Chronic lymphotic leukemia/Small lymphocytic lymphoma

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18
Q

Leukemia. Leukocytosis and absolute lymphocytosis

A

chronic lymphocytic leukemia (CLL)

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19
Q

Lymphomatous

A

small lymphocytic leukemia SLL

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20
Q

Most common leukemia of adults in western world

A

chronic lymphocyctic leukemia

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21
Q

Mostly ppl older than 50. Most pts asymptomatic. WBC counts variable. Hepatosplenomegaly. Immune disruptions. Hypogammaglobulinemia, hemolytic anemia, thrombocytopenia

A

CLL/SLL

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22
Q

Small, mature lymphs with hyperclumped nuclear chromatin. Smudge cells

A

Chronic lymphocytic leukemia

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23
Q

CD19/CD5/CD23
dim CD20
dim surface light chain

A

Chronic lymphotic leukemia/Small lymphocytic lymphoma

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24
Q

Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to diffuse large b cell lymphoma

A

Richter syndrome

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25
indolent | most pts die of other problems
CLL/SLL
26
Germinal center B cells that mimic normal lymphoid follicles. Second most common NHL. BM involvement.
Follicular lymphoma
27
Has 2 cell types (centocytes and centroblasts)
Follicular lymphoma
28
Small cleaved cells
centrocytes
29
Count for grading
Centroblasts
30
Has paratrabecular BM aggregates
follicular lymphoma
31
CD19, CD20, CD10 bright surface light chain BCL2 BCL6
Follicular lymphoma
32
In normal LN, only mantle zone B and T cells stain + for
Bcl2
33
Not easily curable, but indolent.
Follicular lymphoma
34
Normal architecture with follicles of varying size. Mantel zone polarization. Normal germinal centers w/ tingable body macrophages. Normal bcl2 staining in mantle zone
Follicular hyperplasia
35
Architectural disruption with follicles of similar size. No mantle zone, no polarization. Abnormal follicle with no true germinal center. No tingable body macs. abnormal bcl2 staining
Follicular lymphoma
36
Express CD5 and overexpress cyclin D1
Mantle cell lymphoma
37
Hepatosplenomegaly. Mostly BM involvement. PB involvement varies. Has lymphomatoid polyposis or GI involvement
Mantle cell lymphoma
38
MCL
mantle cell lymphoma
39
CD19, CD20, CD5 bright CD20 and surface light chain CD23 negative
mantle cell lymphoma
40
t(11;14)
mantle cell lymphoma
41
Aggressive. Most pts die of organ failure from tumor infiltration. Tx w/ rituximab (anti-CD20) and chemo combo. BM transplant in younger pts Majority ultimately relapse
MCL
42
Tumor cell recapitulates normal MALT tissue. Often extranodal
Marginal zone lymphoma
43
MZL
marginal zone lymphoma
44
In tissues with chronic inflammation. May regress if inciting agent brought under control
marginal zone lymphoma
45
Reactive polyclonal inflammatory rx. | polyclonal > oligoclonal > monoclonal
marginal zone lymphoma
46
Resembless SLL but many neoplastic cells are plasma cells. Mainly BM involvement. Secretes monoclonal IgM causing hyperviscosity
Lymphoplasmacytic lymphoma
47
LPL
lymphoplasmacytic lymphoma
48
Secretes monoclonal IgM causing hyperviscosity syndrome known as
Waldenstrom macroglobulinemia
49
IgM increases blood viscosity causing __________
visual and neurological sxs | Bleeding, autoimmune hemolytic anemia
50
B cells involving blood, BM, and splenic red pulp. Present with sxs related to cytopenias. Splenomegaly, BM involvment Diffuse fried eggs. Round, reniform nuclei with moderate amount cytoplasm. Cells incite reticulin fibrosis
Hairy cell leukemia
51
HCL
hairy cell leukemia
52
Infections, fatigue, weakness are ________ sxs
cytopenia
53
Hairy B cell leukemia has PB involvement, but due to ______ can be hard to find cells
pancytopenia
54
Neoplastic cells sensitive to purine analog type of chemo causing long remissions
hairy cell leukemia
55
ALL
Lymphoblastic leukemia/lymphoma
56
DLBCL
diffuse large B cell lymphoma
57
High grade. | Mostly occurs in immunodeficient pts. Typically associated with EBV
DLBCL
58
Rapidly enlarging, symptomatic mass nodal or extranodal. B symptoms. Large lymphocytes. Mitotically active.
DLBCL
59
CD19, CD20 Surface light chain restriction May or may not have BCL2, BCL6, or CD10
DLBCL
60
cMYC mutation
DLBCL
61
Aggressive and fatal if untreated.
DLBCL
62
Highest grade of high grade
Burkitt lymphoma
63
3 subtypes 1. endemic EBV associated in Africa 2. sporadic in US children 3. Immunodeficient (HIV)
Burkitt lymphoma
64
Translocation involving MYC
Burkitt lymphoma
65
Usually extranodal only. BM and PB involvement unusual
Burkitt lymphoma
66
Usually associated with mandibular or orbital mass
EBV associated Burkitt lymphoma
67
Usually associated with abdominal mass in ileocecum.
Sporadic in US children Burkitt lymphoma
68
Rapid cell death and turnover. Death releases Ca, uric acid, and K. Medical emergency requiring hydration, binding agents for K and uric acid Associated with?
Tumor lysis syndrome Associated with burkitt lymphoma
69
Diffuse infiltrate medium sized cells. Cytoplasmic vacuoles High mitotic activity (>99% proliferation) Many macs creating "starry sky"
burkitt lymphoma
70
CD19, CD20, CD10 surface light chain restriction BCL6
Burkitt lymphoma
71
t(8;14)
burkitt lymphoma
72
Aggressive but responds well to intensive systemic chemo
burkitt lymphoma

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