T cell neoplasms

Question 1

PTCL NOS

Answer 1

Peripheral T cell lymphoma not otherwise specified

Question 2

Eosinophilia. Weight loss.

Diffuse paracortical effacement. Mature T cell. Loss of one or more T cell antigen

Answer 2

Peripheral T cell lymphoma not otherwise specified

Question 3

ALK gene on 2p23.

Answer 3

Anaplastic large cell lymphoma

Question 4

ALCL

Answer 4

anaplastic large cell lymphoma

Question 5

ALK fusion protein acts as ____________

Answer 5

tyrosine kinase

Question 6

Hallmark cells are large, ____________ cells with horseshoe or wreath shaped nuclei

Answer 6

anaplastic

Anaplastic large cell lymphoma

Question 7

T cell or null cell 
No B cell antigens
CD30
EMA
ALK

Answer 7

Anaplastic large cell lymphoma

Question 8

Generally in kids. Good prognosis.

Answer 8

ALK positive

Question 9

Generally in adults. Less favorable prognosis

Answer 9

ALK -

Question 10

T cell counterpart of DLBCL, but worse diagnosis than DLBCL.
Heterogenous group of T cell lymphomas that do not meet criteria for a different entity.

Answer 10

Peripheral T cell lymphoma not otherwise specified

Question 11

CD4 T cells infected with HTLV-1

Answer 11

Adult T cell leukemia/lymphoma

Question 12

Endemic in caribbean basin, Japan, West Africa

Answer 12

HTLV-1

Question 13

Much less aggressive if localized to skin alone

Answer 13

Adult T cell leukemia/lymphoma

Question 14

Leukemic form is rapidly progressive, most die within one year despite chemo

Answer 14

Adult T cell leukemia/lymphoma

Question 15

Has flower/cloverleaf cells

Answer 15

Adult T cell leukemia/lymphoma

Question 16

MF and SS

Answer 16

Mycosis fungoides

Sezary syndrome

Question 17

Skin only

Answer 17

Mycosis Fungoides

Question 18

Progressed from skin to include leukemia

Answer 18

Sezary syndrome

Question 19

MF and SS usually affect

Answer 19

CD4 T cells

Question 20

Has 3 stages

patch > plaque > tumor

Answer 20

MF

Question 21

Generalized exfoliative erythroderma has spread to include leukemia. Involves nodes and BM now

Answer 21

Sezary Syndrome

Question 22

Cerebriform nuclear contours

Answer 22

Neoplastic cell in skin for MF/SS

Question 23

Neoplastic cell in blood for MF/SS

Answer 23

Sezary cell

Question 24

Indolent if limited to less than 10% of body. When extensive, organ involvement occurs

Answer 24

MF/SS

Question 25

LGLL

Answer 25

Large granular lymphocytic leukemia

Question 26

Has T cell type and NK cell type

Answer 26

Large granular lymphocytic leukemia

Question 27

Neutropenia with decreased myeloid maturation in BM Anemia associated

Answer 27

Large granular lymphocytic leukemia

Question 28

Underlying cause of Felty syndrome

Answer 28

Large granular lymphocytic leukemia

Question 29

Rh arthritis, splenomegaly, and neutropenia

Answer 29

LGLL

Question 30

T cell LGLL is _____ | NK cell LGLL is _______

Answer 30

indolent | aggressive

Question 31

Presents as lethal midline granuloma. Aggressive. Invade vessels leading to necrosis

Answer 31

Extranodal NK/T cell lymphoma