Lymphoid Structures & Lymphocytes

Question 1

A secondary lyphoid organ that has many afferents, 1 or more efferents. Encapsulated, with trabeculae.

Answer 1

Lymph Node

Question 2

Site of B cell localization and proliferation

Answer 2

Follice

Question 3

Where do histiocytes reside?

Answer 3

Medulla

Question 4

Houses T cells

Answer 4

Paracortex

Question 5

Not well developed in patients with DiGeorge Syndrome

Answer 5

Paracortex

Question 6

Enlarges in Mononucleosis

Answer 6

Paracortex

Question 7

Head and Neck Drain into what LN cluster?

Answer 7

Cervical

Question 8

Lungs drain into which LN?

Answer 8

Hilar

Question 9

Trachea and Esophagus drain into which LN?

Answer 9

Mediastinal

Question 10

Upper limb, breast, skin above umbilicus drain into which LN?

Answer 10

Axillary

Question 11

Liver, Stomach, Spleen, Pancreas, Upper duodenum drain into whcih LN?

Answer 11

Celiac

Question 12

Lower duodenum, jejunum, ileum, colon to splenic flexure drain into which LN?

Answer 12

Superior Mesenteric

Question 13

Colon from splenic flexure to upper rectum which drain into which LN?

Answer 13

Internal Iliac

Question 14

Testes, Ovaries, Kidneys, Uterus drain into which LN?

Answer 14

Para-aortic

Question 15

Anal canal (below pectinate line), skin below umbilicus (except popliteal area) drain into which LN?

Answer 15

Superficial Inguinal

Question 16

Dorsolateral foot adn posterior calf drain into which LN?

Answer 16

Popliteal

Question 17

Right Lymphatic Duct drains…

Answer 17

right side of body above diaphragm and heart and lungs

Question 18

Where does Thoracic Duct drain into?

Answer 18

Left Subclavian and internal jugular veins

Question 19

In the spleen, where are T cells found?

Answer 19

Periarterial lymphatic sheath, in white pulp of spleen

Question 20

In spleen, where are B cells found?

Answer 20

In follicles wihtin the white pulp of the spleen

Question 21

What do you find in the marginal zone of the spleen?

Answer 21

APCs and specialized b cells where APCs present blood-borne antigens

Question 22

Splenic dysfunction will acuse decrease of what immunoglobulin and complement?

Answer 22

IgM and C3b

Question 23

What type of organisms will a patient be more susceptible to post-splenectomy?

Answer 23

Encapsulated: S. pneumonia, Hib, N. meningitidis, E. coli, Salmonella, Klebsiella pneumonia, group B strep

Question 24

Site of T cell differentiation and maturation.

Answer 24

Thymus

Question 25

Which pharyngeal pouch does the thymus come from?

Answer 25

3rd

Question 26

Where are immature T cells found?

Answer 26

Cortex of thymus

Question 27

Where are mature T cells found?

Answer 27

Medulla of thymus

Question 28

Where do you find Hassall corpuscles?

Answer 28

Medulla of thymus

Question 29

Can get resistance to innate immunity by

Answer 29

mutations in germline

Question 30

Can get resistance to adaptive immunity by

Answer 30

variation through VDJ recombination during lymphocyte development

Question 31

Innate immunity response time to pathogens

Answer 31

minutes to hours

Question 32

Adaptive immunity response to pathogens

Answer 32

highly specific, refined over time | memory response can be rapid and robust

Question 33

pattern recognition receptors that recognize pathogen-associated molecular patterns (PAMPs)

Answer 33

Toll-like receptors, innate immunity

Question 34

LPS (gram negative bacteria), flagellin (bacteria), ssRNA (viruses) are examples of what?

Answer 34

pathogen-associated molecular patterns

Question 35

Chromosome for MHC I and II

Answer 35

6

Question 36

HLA-A, HLA-B, HLA-C are loci associated with which MHC?

Answer 36

MHC I

Question 37

Cells MHC I is presented on

Answer 37

all nucleated cells

Question 38

What presents endogenously synthesized antigens (viral) ?

Answer 38

MHC I

Question 39

What presents exogenously synthesized proteins (bacteria and viral capsids)?

Answer 39

MHC II

Question 40

What uses a TAP peptide transporter for antigen loading?

Answer 40

MHC I

Question 41

Antigen loaded following a release of invariant chain in an acidified endosome

Answer 41

MHC II

Question 42

Beta-2 microglobulin

Answer 42

MHC I

Question 43

Loci for this product are HLA-DR, HLA-DP, HLA-DQ

Answer 43

MHC II

Question 44

only expressed on APCs

Answer 44

MHC II

Question 45

HLA - A3 associated disease

Answer 45

hemochromatosis

Question 46

Which HLA subtype is associated with psoriatic arthritis, ankylosing spondylitis, arthritis of inflammatory bowel disease, reactive arthritis (Reiter)?

Answer 46

HLA- B27

Question 47

HLA subtype associated with Celiac Disease

Answer 47

DQ2/DQ8

Question 48

HLA subtype associated with MS, hay fever, SLE, Goodpasture

Answer 48

DR2

Question 49

HLA subtype associated with DM type 1, SLE, Graves disease

Answer 49

DR3

Question 50

HLA-DR4 is associated with what diseases?

Answer 50

RA and DM type 1

Question 51

HLA-DR5 is associated with what diseases?

Answer 51

Pernicious anemia, vitamin B12 deficiency, Hashimoto thyroiditis

Question 52

2 things released from NK cells to induce apoptosis

Answer 52

perforin and granzymes

Question 53

Express CD56

Answer 53

NK cells

Question 54

IL-2, 12, IFN-beta & alpha enhance activity of what cell?

Answer 54

NK cell

Question 55

When are NK cells induced to kill?

Answer 55

when exposed to a nonspecific activation signal on target cell and/or to an absence of class I MHC on target cell surface

Question 56

MoA of killing antibody-dependent cell-mediated cytotoxicity

Answer 56

NK cell CD16 binds Fc region of bound Ig, activating the NK cell

Question 57

What cell undergoes somatic hypermutation to optimize antigen specificity?

Answer 57

B-cell

Question 58

Cell that help B cells make antibody and produce cytokines to activate other cells of immune system

Answer 58

CD4+ T cell

Question 59

Kill virus infected cells directly

Answer 59

CD8+ T cells

Question 60

Positive selection occurs where?

Answer 60

Thymic cortex

Question 61

T cells expressing TCRs capable ot binding surface cell MHC molecules SURVIVE

Answer 61

positive selection

Question 62

Negative selection occurs where?

Answer 62

Medulla of thymus

Question 63

T cells expressing TCR with high affinity for self-Ags undergo apoptosis

Answer 63

Negative Selection

Question 64

Helper t cell secretes IL-12 to actvate what?

Answer 64

Th1 cell

Question 65

Helper T cell secretes IL-4 to activate what?

Answer 65

Th2 cell

Question 66

Helper T cell secretes TGF-beta + IL-16 to activate what?

Answer 66

Th17 cell

Question 67

Helper T cell secretes TGF-beta to activate what cell?

Answer 67

T-reg cell

Question 68

Costimulatory signal for naive T cell activation include interaction between

Answer 68

B7 and CD28

Question 69

What receptor on the B cell will bind to this ligand on Th cell for CD4+ cell to secrete cytokines?

Answer 69

CD40 receptor on B cell binds CD40 ligand

Question 70

Th1 is inhibited by these products from Th2

Answer 70

IL-4 and IL-10

Question 71

Th1 secretes what cytokine(s)?

Answer 71

IFN-gamma (stimulates macrophages & inactivates Th2)

Question 72

Activates macrophages and cytotoxic T cells

Answer 72

Th1

Question 73

Macrophages release ___ to stimulate T cells to differentiate into Th1

Answer 73

IL-12

Question 74

Recruits eosinophils for parasite defense and promotoes IgE production by B cells.

Answer 74

Th2

Question 75

This cell is inhibited by IFN-gamma

Answer 75

Th2

Question 76

Granzyme B

Answer 76

serine protease from cytotoxic T cells that activate apoptsis inside target cell

Question 77

Granulysin

Answer 77

from cytotoxic T cell, antimicrobial, induces apoptosis

Question 78

Regulatory T cells

Answer 78

suppress CD4 and CD8 T cells

Question 79

Cell surface markers for T-reg cell

Answer 79

CD3, 4, 25, and TF FOXP3

Question 80

There's a what in my boot?

Answer 80

A snake in my boot!!!