lysosome Flashcards Preview

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Flashcards in lysosome Deck (6):
1

deliver membrane proteins to lysosome with

multivesticular endosome

2

deliver cytosolic proteins to lysosome with

autophagy

3

multivesticular endosome mech

Ubiquitin- tag for cargos going into MVB (monounbiquitin), ESCRT complex is recruited by
ubiquitn-tagged Hrs protein, ESCRT proteins drive vesicle budding
into the lumen, loading of
monoubiquitinated membrane cargos
into vesicle buds, pinching off, Vps4, an ATPase, disassemble
ESCRT complex, ESCRT and Vps4 function as SNARE
and NSF

4

budding viruses

sim to MVB but uses Gag molecules to form a shell, Tsg101 (ESCRT protein) binds to Gag

5

autophagy

recycling of macromolecules for use as nutrients under stress,
such as starvation

6

autophagy mech

formation of flattened double-membrane cup shaped structure to envelop an entire organelle, outer membrane of autophagic vesicles fuse with lysosome, Enzymes in lysosome
degrade the autophagic
vesicles