Targeting Seq's- Proteins from Cytosol to Organelles Flashcards Preview

BICD 110 > Targeting Seq's- Proteins from Cytosol to Organelles > Flashcards

Flashcards in Targeting Seq's- Proteins from Cytosol to Organelles Deck (7):
1

ER (lumen)

Core of 6-12 hydrophobic AA's, often preceded by one or more basic AA's (Arg, Lys)

2

Mitochondrion (matrix)

Amphipathic helix, 20-50 residues in length, with Arg and Lys residues on one side and hydrophobic residues on the other

3

Chloroplast (stroma)

No common motifs; generally rich in Ser, Thr, and small hydrophobic residues and poor in Glu and Asp

4

Peroxisome (matrix)

PTS1 signal (Ser-Lys-Leu) at extreme C-terminus; PTS2 signal at N-terminus

5

Nucleus (nucleoplasm)

Multiple different kinds; a common motif includes a short segment rich in Lys and Arg residues

6

location of seq

all in N term except peroxisome (mostly in C term) and nucleus (varies)

7

removal of seq

all except peroxisome and nucleus