M10

Question 1

Beck went to the laboratory for a creatinine test. During extraction, the medical technologist was unable to locate his vein so he was advised to do fist clenching repeatedly. How will this action affect the test?
It will not affect the test.
Blood drawn will be hemolyzed and will falsely increase the creatinine level.
It will temporarily release bilirubin and will falsely elevate creatinine.
It triggers muscle contraction and will falsely increase creatinine.

Answer 1

-It triggers muscle contraction and will falsely increase creatinine.

Question 2

When the Jaffe reaction is employed as a kinetic assay to accurately measure serum creatinine, which of the following is used in the analysis?
Plasma
Serum
Folin Wu PFF
Whole blood

Answer 2

Serum

Question 3

Lester has been taking Aspirin as maintenance for cardiovascular disease. Lately, he has complained of intense joint pains, especially in his big toe. His physician requests him to have his uric acid levels checked. What possible interference and its effect can be considered in this scenario?
Thiazide diuretics have been shown to increase uric acid levels
no interference can be caused
Cephalosporins may increase uric acid levels.
Salicylates have been shown to increase uric acid levels

Answer 3

-Salicylates have been shown to increase uric acid levels

Question 4

What is the urea concentration in mg/dL if the patient’s BUN is 15 mg/dL?
42.1 mg/dL
32.1 mg/dL
70.0 mg/dL
50.4 mg/dL

Answer 4

-32.1 mg/dL

Question 5

Which of these substances can cause false elevation on the level of serum creatinine especially if measurement is done by Jaffe reaction at temperatures above 30°C.?
Uric acid
Dopamine
Urea
Lidocaine

Answer 5

Lidocaine

Question 6

Which of the following choices will likely cause urea levels to increase in the body?
All of the choices are correct
Sudden kidney function loss due to intrinsic renal diseases
formation of hard deposits of minerals inside the kidney
allergic reaction causing shock to the patient

Answer 6

-All of the choices are correct

Question 7

Zeke is experiencing pre-renal azotemia because of congestive heart failure. Choose the best explanation for the rise in urea levels in his blood.
Presence of bacteria that produces urea
Lesions develop in the kidney due to overwork
Less blood is delivered to the kidney
Peripheral artery obstruction in the kidney

Answer 7

-Less blood is delivered to the kidney

Question 8

What term originated in the early days of clinical chemistry when analytic methodologies required the removal of protein?
Protein-free filtrate
Creatine
Non-protein nitrogen
Creatinine

Answer 8

Non-protein nitrogen

Question 9

Which of the following is a direct method for determining urea?
Henry method
Jaffe reaction
Fearon reaction
Lloyd’s method

Answer 9

Jaffe reaction

Question 10

In the coupled uricase reaction, which enzyme oxidizes the chromogen?
Glutamate dehydrogenase
Glucose oxidase
Peroxidase
Xanthine oxidase

Answer 10

Glucose oxidase

Question 11

If there is a decreased blood flow in the kidneys, how will it affect the urea levels in the body?
There will be a decrease in the amount of urea in the body, because the kidneys will not be able to produce the analyte.
There will be an increase in the value of plasma urea since there is less filtration of the analyte in the blood
There will be a transition value of Urea, from high to low, due to the metabolism of the body cells of urea in the blood.
There is no change in the Urea levels in the body since there is no relation between the blood flow and the filtration of the analyte,

Answer 11

-There will be an increase in the value of plasma urea since there is less filtration of the analyte in the blood

Question 12

Which of the following will cause renal azotemia?
Chronic renal failure
Renal calculi
Dehydration
Hemorrhage
-

Answer 12

Chronic renal failure

Question 13

Which of the statements below is TRUE regarding creatinine?
It is filtered in the glomeruli and undergoes significant tubular reabsorption
It is a product of protein catabolism in humans
It is synthesized in the liver
It is a waste product of creatine and creatine phosphate

Answer 13

-It is a product of protein catabolism in humans

Question 14

Which of the following will not cause post-renal azotemia?
Congenital Heart Disease
Prostate cancer
Severe urinary tract infection
Renal calculi

Answer 14

-Congenital Heart Disease

Question 15

Statement A: Creatinine is used to monitor the progression of kidney disease.
Statement B: Hemolyzed samples may be used as long as a correction blank was performed.
Which of the following is CORRECT with respect to the above statements?
Both statements are false
Statement B is true statement A is false
Statement A is true Statement B is false
Both statements are true

Answer 15

-Statement A is true Statement B is false

Question 16

What is the wavelength used in the enzymatic method for BUN determination?
650 nm
500 nm
340 nm
480 nm

Answer 16

-340 nm

Question 17

How would you prepare alkaline pirate for the Jaffe method?
2 mL 10% Na0H and 10 mL Picric acid
3 mL 5% Sodium hydroxide and 10 mL Picric silicate
1 mL 20% NaH and 4 mL Sodium aluminum silicate
1 mL Picric acid and 5 mL NaOH

Answer 17

-2 mL 10% Na0H and 10 mL Picric acid

Question 18

Which of the following are the appropriate specimen considerations and patient preparations to be observed for the determination of uric acid levels?
1. Sodium fluoride may be used as an anticoagulant.
2. Fasting may be required for diagnostic purposes.
3. Heparinized plasma may be used as the sample.
3
2,3
1,2,3
1,3

Answer 18

-2,3

Question 19

To convert the SI unit of Uric Acid to its Conventional unit, which formula should be used?
multiply the value by 59.5
divide the value by 59.5
divide the value by 0.357
multiply the value by 0.0595

Answer 19

-divide the value by 59.5

Question 20

In which of the following will creatinine react with to form Janovsky complex?
1.20% Sodium hydroxide
2. Picric acid
3. 10% NaOH
4. Sodium aluminum silicate
1.2
2,3
2,4
3,4

Answer 20

-2,3