M2: Adrenoreceptor Antagonist Drugs

Question 0

Reversible agonist

Answer 0

Phentolamin & Prazosin

Question 1

May be reversible or irreversible

Answer 1

Alpha receptor antagonism

Question 2

Irreversible antagonist

Answer 2

Phenoxybenzamine

Question 3

Dec peripheral vascular resistance leads to orthostatic hypotension and reflex tachycardia. Miosis. Nasal stuffiness. Dec resistance to urine outflow.

Answer 3

Alpha 1 receptor antagonist

Question 4

Irreversible A1 antagonist. Inhibition of NE uptake. Blocks sero, acetyl & etc. Attenuation and potentiation of catecholamine induced vasoconstriction. Treatment for pheochromocytoma. Given per orem.

Answer 4

Phenoxybenzamine

Question 5

Diagnosis for Pheochromocytoma

Answer 5

Measure VMA & Ultz

Question 6

Metabolic product of catecholamine breakdown

Answer 6

VMA

Question 7

Orthostatic hypo, tachy, nasal stuffiness, inhibition of ejaculation.

Answer 7

SE & AE of phenoxybenzamine

Question 8

Competitive antagonist of A1 & A2 receptors. Dec peripheral vascular resistance. For pheochromocytoma

Answer 8

Phenotalamine

Question 9

Highly selective for A1 receptors. Relaxation of arterial & venule smooth muscle . For BPH. Relaxation of prostate muscle. Mgt for HPN

Answer 9

Prazosin/Minipress

Question 10

Reversible A1 antagonist. For HPN & BPH. Extensively metabolized in the liver. Not usually used for HPN.

Answer 10

Terazosin

Question 11

Half life is 22hrs. Longer. For HPN & BPH.

Answer 11

Doxazosin

Question 12

A1 antagonist. High bioavailability. Inhibition of contractions in prostate smooth muscles. Less effect on standing BP.

Answer 12

Tamsulosin

Question 13

Hypersecretion of catecholamines. Hypertension, headache, palpitation & excessive sweating.

Answer 13

Pheochromocytoma

Question 14

Mild to moderate systemic HPN. Major adverse effect is orthostatic hypotension.

Answer 14

Chronic HPN

Question 15

Peripheral Vascular Dse: Ar blocking agents are not effective. For reynauds phenomenon

Answer 15

Prazosin & Phenyoxybenzamine

Question 16

Urinary Obstruction

Answer 16

Prazisin, Doxasozine, Terazosin& tamsulosin

Question 17

Beta blockers: good oral absorption. Peak plasma concentration

Answer 17

1-3hrs after ingestion

Question 18

Extensive first pass effect among BetaB. Low bioavailability. Noncardio selective. Notorious for asthma attacks. For hyperthyroidism.

Answer 18

Propanolol

Question 19

BetaB that Cross the BB

Answer 19

Propanolol & Penbutolol

Question 20

Half life is 10mins

Answer 20

Esmolol

Question 21

Longest half life of 24hrs

Answer 21

Nadolol

Question 22

Lower BO via (-) inotropic & chronotropic effects. Increas peripheral resistance.

Answer 22

BetaB

Question 23

BetaB: _______ in airway resistance as a result of ______.

Answer 23

Inc. Bronchoconstriction.

Question 24

BetaB: in eye. Dec prod of ________ in px with glaucoma. Dec IOP.

Answer 24

Aqueous humor

Question 25

BetaB: metabolism. Inhibition of

Answer 25

Lypolysis & Glycogenolysis

Question 26

BetaB: metabolism. Inc _____

Answer 26

Vldl

Question 27

Prototype BetaB. Low bioavailability. Use for HPN, angina, dysrhythmia & hyperthyroidism.

Answer 27

Propanolol

Question 28

Beta1 selective. Safer in px who experience bronchoconstriction and COPD

Answer 28

Metoprolol

Question 29

Highly selective B1 blocker. Elicit vasodilation. Good for CHF.

Answer 29

Nevibolol

Question 30

Long duration. Spectrum similar to timolol.

Answer 30

Nadulol

Question 31

Non selective, ocular hypotensive effects. For patients with glaucoma

Answer 31

Timolol

Question 32

Topical opthalmic with glaucoma

Answer 32

Levobunolol & Betaxoxol

Question 33

Less likely to produce bradycardia & plasma lipid abnormalities

Answer 33

Pindolol, acebutolol, carteolol

Question 34

Potent A & B blocker

Answer 34

Labetalol

Question 35

Ultra short acting B1 blocker. Short half life 10mins. Used for SVP, perioperative HPN & antianginal agent

Answer 35

Esmolol

Question 36

Hypertension. Effective & well tolerated. Used with a diuretic & vasodilator. Administered once or twice daily.

Answer 36

Beta Blockers

Question 37

Used for ischemic heart dse. Dec O2 demand. Improve exercise tolerance and reduce anginal episodes. Improve survival following AMI.

Answer 37

Timolol, propanolol & metoprolol

Question 38

Reduce ventricular ectopic beats.

Answer 38

Bblockers

Question 39

Reduce mortality in pxs with CHF

Answer 39

Metoprolol, Bisoprolol & Carvedilols

Question 40

For local us glaucoma which reduces IOP

Answer 40

Timolol

Question 41

Excessive catecholamine action. Inhibition of T3 & T4.

Answer 41

Propranolol

Question 42

Used for migraine, somatic manifestations of anxiety & alcohol withdrawal.

Answer 42

Propranolol