Macrocytic anaemia Flashcards by Fu Chuen

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Q

What is the difference between megaloblastic and non-megaloblastic anaemia?

A

Megaloblastic characterised by presence of immature red cells (megaloblasts) while non-megaloblastic characterised by just large red cells

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Q

Give 5 causes of non-megaloblastic anaemia

A

Liver disease
Hypothyroidism
Pregnancy
Alcohol
Smoking

Haematological malignancy:

myelodysplasia
pure red cell aplasia
myeloma
reticulocytosis

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Q

2 causes of megaloblastic anaemia

A

B12 deficiency

Folate deficiency

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Q

B12 deficiency with neurological involvement, what is the most likely diagnosis?

A

Subacute degeneration of the spinal cord

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Q

What is the treatment for B12 deficiency?

A

Neurological involvement:

seek urgent specialist haematology advice
hydroxocobalamin IM injection 1mg on alternative days

No neurology involvement:
- hydroxocobalamin IM injection 1mg 3 days a week

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