Maggie Flashcards

1
Q

describe biliary colic pain

A

is a symptom not a diagnosis

pain can radiate to right flank and even tip of shoulder blade

tends to increase post meals

pain builds up in waves and comes and goes

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2
Q

causes of biliary colic

A
  • gall stones in duct - episodic pain as gallstiones pass and then come back
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3
Q

cholecystitis

A

inflammation of gallbladder

  • pain in RUQ
  • murphys sign
  • doesn’t typically cause colic pain on its own

(doesnt alone give jaundice)

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4
Q

describe Murphys sign

A

prominent pain when taking a deep breath with an examining hand just below right costal margin

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5
Q

what is ‘guarding’ and what does it imply

A
  • examining for a tightening or muscle contraction
  • can be both voluntary and involuntary
  • involuntary is a sign of peritoneal inflammation e.g. seen in cholecystitis and appendicitis
  • rebound tenderness
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6
Q

why is cholesterol gallstones formed in the gallbladder not in the bile duct

A
  • bile becomes concentrated in gallbladder, which can cause precipitation of cholesterol
    = gallstones
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7
Q

what initiates emptying of gallbladder

A

cholecystokinin

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8
Q

define cholelithiasis

A

presence of gallstones in the gallbladder solely

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9
Q

define choledocholithiasis

A

presence of gallstones in the bile duct

  • usually, cholesterol stones as they originate from gallbladder
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10
Q

define cholangitis

A

presence of infection due to an obstructed bile duct

e.g. choledocholithiasis with infection

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11
Q

what does increased GGT and ALP mean

A

patient has cholestasis

  • decreased bile flow
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12
Q

what is the diagnosis

  • elevated GGT & ALP
  • high fever and rigors
  • elevated bilirubin
  • US shows obstructed common bile duct
A

cholangitis due to choledocholithiasis

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13
Q

consequences of cholangitis due to choledocholithiasis

A

pancreatitis - important to check pancreatic enzymes

common bile duct joined by pancreatic duct

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14
Q

common causes of cholestasis

A
  • stones
  • biliary disease - autoimmune
    (e. g. primary biliary cirrhosis or primary sclerosing cholangitis)
  • drugs & medications
  • tumours
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15
Q

Charcot’s triad and what it can means

A
  • fever
  • jaundice
  • RUQ pain

= cholangitis

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16
Q

describe MRCP

A

magnetic resonance cholangiopancreatography

  • useful accurate visualisation of biliary tree
  • advantage = non-invasive
  • disadvantage = non-therapeutic (doesnt tx)
17
Q

describe ERCP

A

endoscopic retrograde cholangiopancreatography
- contrast

  • diagnostic and therapeutic

disadvantages = risk of complications (bleeding or perforation)
- doesn’t prevent it occurring again

18
Q

describe PBC

A
  • primary biliary cirrhosis
  • autoimmune chronic cholestatic liver disease
  • diagnosed by +ve AMA (anti-mitochondrial antibody)
  • affects small intrahepatic bile ducts (not detectable on imaging)
19
Q

diagnosis of PBC requires what

A

2 out of the 3:

  • high ALP (cholestasis)
  • positive AMA
  • liver biopsy
20
Q

presentation of PBC

A

50-60 % are asymptomatic

early symptoms

  • fatigue
  • pruritus (itch even w/out jaundice)
  • may have steatorrhoea

progressive disease

  • jaundice
  • liver cirrhosis

will get progressive increase in ALP and GGT

21
Q

treatment for PBC

A

UDCA

  • ursodeoxycholic
  • slows down progression
22
Q

describe PSC

A
  • primary sclerosing cholangitis
  • chronic cholestastic liver disease
  • affects extra- and intrahepatic bile ducts
  • immune mediated but antigen unknown
23
Q

diagnosis of PSC

A
  • radiology (MRCP/ERCP)

- occasionally requires liver biopsy

24
Q

presentation of PSC

A
  • often associated with ulcerative colitis

early symptoms

  • fatigue
  • pruritus (itch even w/out jaundice)
  • may have steatorrhoea

progressive disease

  • jaundice
  • liver cirrhosis
  • cholangitis
25
Q

treatment for PSC

A
  • no medication to slow
  • can dilate or stent strictures in large ducts
  • last resort liver transplant
26
Q

tumours causing obstructive jaundice

A

pancreatic cancer
- head of pancreas

cholangiocarcinoma (cancer of bile ducts)

painless jaundice often tumour

27
Q

risk factors for viral hepatitis

A
  • travel
  • IV drug use
  • sexual partners
  • vaccinations
  • blood transfusions
28
Q

what is commonly associated with PSC

A
  • osteoporosis

- ulcerative colitis