Major Histocompatibility Complex And T-Cell Receptor Flashcards Preview

Block 6 - Immunology > Major Histocompatibility Complex And T-Cell Receptor > Flashcards

Flashcards in Major Histocompatibility Complex And T-Cell Receptor Deck (7)
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1
Q

Describe HLA/MHC Class I and II in terms of…

  • The chromosome that codes for them
  • Their major loci
  • What tissues they are found on
  • Which T-cells recognize each class
A

Class I:

  • Chromosome: Short arm of chromosome 6
  • Major Loci: A, B, C
  • Tissues: all nucleated cells
  • T-cells: Cytotoxic T-cells (CD-8)

Class II:

  • Chromosome: Short arm of chromosome 6
  • Major Loci: DP, DQ, DR
  • Tissues: B-Cells, Antigen-Presenting Cells, Macrophages
  • T-Cells: T-helper Cells (CD-4)
2
Q

Recognize the MHC Class I and II domains responsible for binding antigen and the types of antigens presented

A

Class I:

  • Viruses, Intracellular Bacteria, Mutations
  • Peptide binding domain: alpha 1/alpha 2 (long alpha chain, short beta 2-microglobulin)
  • Endogenous Antigens (not phagocytized)

Class II:

  • Bacteria
  • Peptide binding domain: alpha 1/beta 1 (long alpha and beta chain)
  • Exogenous Antigens (phagocytized material)
3
Q

Recognize the structure of the T-cell receptor (TCR) and explain the function of the CD3 complex

A
  • Heterodimer with one alpha chain and one beta chain
  • Top region is variable and binds antigen (epitope) presented by MHC-I or by MHC-II

CD3 Complex: required for TCR development and function; important in signal transduction after activation

4
Q

Know which type of lymphocytes express CD4, CD8, and CD28

A

CD-4: MHC Class II
CD-8: MHC Class I
CD-28: co-stimulatory molecules with ligands (T-Cells)

5
Q

Explain the function of TCR accessory molecules

A

Stabilize the TCR/CD3:MHC complex

6
Q

Differentiate the roles of TH1 and TH2 lymphocytes

A

TH1: promote CELL-mediated responses
- Drive differentiation of cytotoxic T cells and natural killer cells

TH2: promote ANTIBODY-mediated responses
- Drive B cell activation and differentiation

7
Q

Which (if any) of the following cells lack MHC-1?

  • Neutrophils
  • Lymphocytes
  • Red Blood Cells
A

Red Blood Cells