Malabsorption physiology and disease Flashcards
Screen for malabsorption
Screen for malabsorption
Stool gap
Whipple Dx
atrophied vili and foamy macrophages, lymphactic dilation, confirm dx with EM or PCR, this is not acid fast staining
Also get a CSF PCR to get CNS involvement
Treatment: Ceftriaxone and bactrim (long term)
Autoimmune enteropathy
anti-enterocyte or anti-goblet antibodies
Bx of autoimmune enteropathy
Treatment : supportive car
Immunosupressio, steriods, can also do tacrolimus, sirolimus, cellcept, 6mp
Collagen sprue
similar to collagen colitis
path: subepithelial layer of collagen (trichrome) extending to the lamina propia and vilous atropy
treatment: supprotive, steriods, combination therapy of 6mp, antiTNF
Small bacterial overgrowth
high folate (bacteria can produce folate and low B12)
eosinophilic enteritis
depends on the layer of the GI tract that is involved
eosinophilic enteritis
PLE/Lymphangiectasia
low fat diet, and MCT (do not need bile salts for absorption, water soluble and does not need chylomicrons to be absorpbed since they are not traveling through the lymphactics
MCT
radiation enteritis
dx of imaging
CVID
pauctiy of the plasma cells (opposite to the autoimmuen mediated disease)
Tropical sprue
Still dont know what organism, infectious bc the antibiotics helps
Bile acid diarrhea
bile acids made in the liver, stored in gallbladder and release in the intestine then reabsorb in the TI
Depends on how much resection of the ileum
for cholcystectomy (bile gets stored in teh small intestine and get diarrhea bc of malabsorption)
Carbs malsborption
Other tests
