Malaria

Question 1

The most severe specie of malaria

Answer 1

Falciparum

Question 2

The most common specie of malaria

Answer 2

Vivax

Question 3

Signs of malaria

Answer 3

Pallor, jaundice, hepatosplenomegaly

Question 4

Constant fever is found with

Answer 4

Falciparum

Question 5

Fever every 72h

Answer 5

Malaria

Question 6

Fever every 48 h

Answer 6

Vivax + Ovalea

Question 7

Complications of malaria

Answer 7

Cerebral malaria 
DIC and circulatory collapse
Renal (black water fever), liver failure and splenic rapture 
ARDS
Hypoglycemia & Lactic acidosis

Question 8

Cerebral malaria is caused by

Answer 8

Falciparum

Question 9

Black water fever is caused by

Answer 9

Falciparum

Question 10

Infective stage occur by release of

Answer 10

Merozoites

Question 11

Mechanism by which falciparum causes complications

Answer 11

Erythrocytes membrane protein 1 - clumping - blocking small blood vessels

Question 12

Diagnosis of malaria

Answer 12

Giemsa stain
PCR
Paracetemia level
Additional (CBC, LFT, metabolic, coagulation profile)

Question 13

Types of gimsa stains and difference

Answer 13

Thick - malarial screening

Thin - malarial identifiaction and staging

Question 14

Percentage of paracetemia which indicate severe disease

Answer 14

> 5%

Question 15

CBC results

Answer 15

Anemia, thrombocytopenia

Question 16

LFT

Answer 16

Hyperbilirubinemia - hemolysis

Question 17

Metabolic

Answer 17

Metabolic acidosis and hypoglycemia

Question 18

Coagulation profile

Answer 18

Prolong PT & PTT (DIC)

Question 19

Primaquine is used for

Answer 19

Hypnozoites

Ovals & vivax

Question 20

Treatment in chloroquine sensitive plasmodium

Answer 20

10 tab regimen 
4 in clinic 
After 8 hours - 2
Next day 2 
Third day 2

Question 21

Main anti malarial drugs

Answer 21

Chloroquine, primaquine, quinine, mefloquine, deoxycycline

Question 22

Treatment of chloroquine resistance P.falciparum

Answer 22

Artesunate (3days) + mefloquine (2nd and 3rd day)

Quinine (7 days)+ doxycycline

Question 23

Treatment of severe complicated malaria

Answer 23

IV Quinine + artemisin derivatives

Question 24

When to start chemoprophylaxis

Answer 24

All travelers who travel to endemic area

Started 1 week before and continued 4 weeks after leaving area

Question 25

Chemoprophylaxis for chloroquine sensitive area

Answer 25

Chloroquine

Question 26

Chemoprophylaxis for chloroquine resistance area

Answer 26

Mefloquine or doxycycline

Question 27

Conditions resistance to malaria

Answer 27

Sickle cell trait (HbA/HbS) HLA-B53 Duffy antigen

Question 28

Hyper reactive malarial splenomegaly is caused by

Answer 28

P.malariae

Question 29

IgM, splenomegaly, malaria endemic area, high lymphocytes, no response to anti malaria treatment

Answer 29

Hyperactive malarial splenomegaly

Question 30

Chemoprophylaxis in pregnancy

Answer 30

Chloroquine & mefloquine