Male reproductive system Flashcards
(104 cards)
- Which of the following favour chronic rather than acute/ subacute torsion of the spermatic cord?
A. Enlarged testis with spherical morphology
B. Good identifcation of the lobular architecture of the affected testis
C. Thickened mediastinum, less echogenic than contralateral
D. Enlarged and more spherical epididymis
E. Hypoechoic small and harder testis
E. Hypoechoic small and harder testis
Absence of hydrocele and normal scrotal wall/skin are other features of chronic torsion.
- A 60-year-old man with elevated PSA and a Gleason 4+3 tumour undergoes investigation with MRI of the prostate. Which is the single best answer?
A. Tumour of the gland is low signal on T2
B. Tumour appears bright on the Apparent Diffusion Coeffcient (ADC)
C. Tumour appears dark on high b-value DWI images
D. Seminal vesicle involvement indicates T2 disease
E. The inguinal nodes are the frst to enlarge with disease progression
A. Tumour of the gland is low signal on T2
Tumor appears as a focus of low signal compared to the normal high signal peripheral zone on T2.
T3 disease indicates extracapsular extension and/or seminal vesicle involvement.
Tumour appears dark on ADC and bright on high b-value DWI images.
Obturator nodes are frst to become involved.
- Non seminomatous Germ Cell Tumour is diagnosed in a 30-year-old man. Which is the single best answer?
A. Non seminomatous Gem Cell Tumour from the majority of testicular Gem Cell Tumour
B. Left-sided tumours frequently metastasize to left PA nodes just above level of left renal vein
C. Right-sided tumours spread initially to aortocaval lymph nodes
D. Echelon nodes are usually left-sided nodes lateral to PA nodes
E. Imaging appearances of nodal disease at late relapse is often more predictable than at initial presentation
C. Right-sided tumours spread initially to aortocaval lymph nodes
Late relapse > 2 years after CR, in absence of second primary tumour. Occurs in up to 7% of patients with less predictable pattern of nodal spread.
NSGT form 40% of testicular GCT compared with 60% seminomatous.
Leftsided tumours metastasize to left PA nodes below the level of the renal vein.
Echelon nodes are usually rightsided, anterior to right psoas
- Which of the following most favours a diagnosis of adult prostate sarcoma rather than adenocarcinoma?
A. Age of patient: 50
B. Size of tumour: 2.3cm
C. Absence of calcifcation
D. Solid and cystic components
E. Invasion of the bladder wall
D. Solid and cystic components
Prostatic sarcomas represent 0.1% of all primary prostate malignancy in adults.
Mean age is younger than that of adenocarcinoma.
Typically presents as a large solid and cystic mass with rapid hypervascular and heterogenous soft tissue occupying all or most of the prostate.
- Considering solid lesions of the paratesticular space, which is the most common benign tumour?
A. Adenocarcinoid tumour
B. Lipoma
C. Haemangioma
D. Leiomyomas
E. Papillary cystadenomas
A. Adenocarcinoid tumour
30% of all paratesticular masses and most common benign neoplasm. Hamartomatous lesions are of probable
mesothelial origin in young adults and usually present either as a painless mass or an incidental fnding
- In prostate cancer, which best describes changes in Magnetic Resonance Spectroscopy (MRS)?
A. Elevated choline
B. Reduced citrate
C. Elevated choline:citrate ratio
D. Elevated citrate:choline ratio
E. Combining MRI with MRS has no increased accuracy in diagnosis of prostate cancer
C. Elevated choline:citrate ratio
Elevated choline + creatine: citrate ratio best describes MRS features of prostate cancer
- Regarding MRI prostate seminal vesicles:
A. Usually low on T2
B. Usually high SI on Diffusion Weighted Imaging (DWI)
C. Typically have low ADC values
D. Are high signal on T2 when atrophic
E. Are low signal when invaded with tumour
E. Are low signal when invaded with tumour
Seminal vesicles may appear low in signal on T2 when atrophic, empty or with tumour involvement
- Regarding prostate MR:
A. The Peripheral Zone (PZ) and Transitional Zone (TZ) are diffcult to distinguish on MR
B. Volume of prostate gland > 60cc precludes brachytherapy
C. The normal PZ is typically heterogeneous on T2
D. Haemorrhage appears as low SI on T1
E. Tumours occur more commonly in TZ than PZ
B. Volume of prostate gland > 60cc precludes brachytherapy
Contraindications to brachytherapy include a volume of over 60cc
7) A 40-year-old man has a testicular ultrasound scan, which demonstrates a multilobular mass that is
homogeneous and hypoechoic with Doppler flow seen in internal hypoechoic bands. Which of the following is
the most likely diagnosis?
a. teratoma
b. lymphoma
c. metastasis
d. seminoma
e. focal infarction
d. seminoma
Ninety-five per cent of testicular tumours are germ cell tumours. Others include sex-cord and stromal tumours
such as Leydig cell and Sertoli cell tumours. Primary lymphoma and metastases can also occur in the testicle.
Non-seminomatous germ cell tumours include teratoma, embryonal carcinoma and choriocarcinoma, but these
affect a younger population of 20–30 years. Ultrasound scan is the investigation of choice for detection of a
testicular tumour and for assessing normality of the contralateral testicle. Seminomas present with mass or pain,
and are generally lobulated masses on ultrasound scan with hypoechoic fibrovascular septations in which colour
flow can be visible. T2W MRI demonstrates uniform intermediate signal with band-like low-signal septa. There
is contrast enhancement, especially of the septations. They rarely calcify, but, if they do, the calcification is
speckled or stippled.
19) A 20-year-old man has radical orchidectomy for a non-seminomatous germ cell tumour. A CT of the thorax,
abdomen and pelvis shortly after surgery shows no lymphadenopathy or metastasis. Which of the following is themost appropriate follow-up regimen?
a. repeat CT of the chest, abdomen and pelvis only in response to symptoms suggesting recurrence
b. repeat CTof the chest, abdomen and pelvis only when serum tumour markers rise
c. serial serum tumour marker measurement with yearly CT of the chest, abdomen and pelvis
d. serial serum tumour marker measurement with 3-monthly CTof the chest, abdomen and pelvis for 1 year
followed by 6-monthly CTof the chest, abdomen and pelvis for 1 year
e. 3-monthly whole-body PET/CT
d. serial serum tumour marker measurement with 3-monthly CTof the chest, abdomen and pelvis for 1 year
followed by 6-monthly CTof the chest, abdomen and pelvis for 1 year
Stage 1, non-seminomatous, germ cell tumour patients should enter a surveillance programme of this type
following orchidectomy. Such programmes are rarely used for seminoma, particularly when retroperitoneal
radiation treatment is used.
Rising tumour markers between surveillance scans or thereafter should provoke CT of the chest, abdomen and pelvis plus ultrasound scan of the remaining testicle. If no new disease is identified, MRI of the brain is indicated.
20) On ultrasound scan, a 30-year-old man is found to have bilateral testicular microlithiasis and unilateral
testicular atrophy. There is a history of orchidopexy of the atrophic testicle. Which of the following is the most
appropriate management?
a. discharge
b. self-examination only
c. follow-up clinical examination and surveillance sonography
d. further investigation with MRI
e. testicular biopsy
c. follow-up clinical examination and surveillance sonography
Atrophic maldescended testes are at higher risk of developing malignancy, particularly seminoma, even after
orchidopexy. The increased risk applies to the contralateral testicle also. Microlithiasis is also associated with
testicular cancer. In combination, these features require clinical and sonographic follow-up.
22) A 50-year-old man complains to his general practitioner of painful sexual intercourse. An ultrasound
examination of the penis is performed, which identifies dense, shadow-casting abnormalities of the periphery of
both corpora cavernosa. What is the likely diagnosis?
a. priapism
b. Zoon’s balanitis
c. penile squamous cell carcinoma
d. Peyronie’s disease
e. balanitis xerotica obliterans
d. Peyronie’s disease
The cause of Peyronie’s disease is unknown, but the result is fibrous thickening of Buck’s fascia and the septum
between the corpora cavernosa. Calcified plaques are also seen. The fibrous areas do not engorge with blood,
causing the penis at erection to be bent; this can make intercourse painful or impossible. Priapism is persistent
painful erection of the penis but is not associated with penile calcification. Zoon’s balanitis is an idiopathic
lymphocytic inflammatory condition of the penis, which may respond to topical steroid but is also treated by
circumcision. Balanitis xerotica obliterans is the severe form of penile lichen sclerosus, which is an uncommon
inflammatory dermatosis. It can cause phimosis and urinary retention.
23) A 16-year-old male with a history of recurrent sudden severe testicular pain at night has a surgical scrotal
exploration, which establishes that one testicle has a high insertion of the tunica vaginalis on the spermatic cord.
What proportion of patients with this condition will have bilateral disease?
a. none
b. 10%
c. 25%
d. 65%
e. all
d. 65%
A bell-clapper deformity is described. This is bilateral in 50–80% of cases. High insertion of the tunica vaginalis
on the spermatic cord means that this tunica completely surrounds the testis, epididymis and distal spermatic cord,
allowing intravaginal torsion. Extravaginal torsion is rare occurs when testis and tunica twist at the external ring.
24) On an axial MRI of the penis, three tubular masses of tissue, occupying much of the cross-sectional area of
the penis, are entirely surrounded by a T1- and T2-hypointense layer. Breach of this layer upstages a penile cancerfrom T1 to T2. From the following choices, name this structure or structures.
a. corpora cavernosa
b. corpora spongiosa
c. cavernosal arteries
d. urethra
e. tunica albuginea
e. tunica albuginea
Invasion of the corpora cavernosa or corpora spongiosa by a penile cancer is via the tunica albuginea, making the
local stage T2. If the urethra, found centrally within the corpora spongiosa, is involved, it becomes T3. Each
corpus cavernosum contains a central artery. Having rapidly flowing blood, this will also be hypointense on both
T1W and T2W images because of flow void.
(Ped) 30) An 8-year-old boy has sudden-onset, severe, unilateral, testicular pain. What is the most likely cause?
a. torsion of appendix testis
b. torsion of appendix epididymis
c. torsion of testis
d. epididymitis
e. orchitis
c. torsion of testis
Torsion of the testicle is the commonest acute problem in the prepubertal age group. Including all ages below 20
years, epididymitis occurs in a ratio of 3:2 with torsion. This ratio is 9:1 above 20 years. Torsion of the testicular
appendages accounts for around 5% of scrotal pathology overall, with the appendix testis being affected far more
commonly than the appendix epididymis.
36) A 70-year-old man with biopsy-proven prostate carcinoma has an MRI of the prostate to assess suitability for
radical prostatectomy. There is bilateral, multifocal, peripheral-zone, low-signal change on small FOV T2W
images in locations corresponding on more than one scan plane. These changes are confined within the prostatic
capsule. However, enlarged lymph nodes are seen in the left internal and common iliac groups. No other disease
is seen, including on a CT of the abdomen and pelvis and a radioisotope bone scan. What is the TNM stage of
this patient’s cancer?
a. T2b N1 M0
b. T2c N1 M0
c. T2c N1 M1
d. T3 N1 M0
e. T3 N1 M1
c. T2c N1 M1
Being bilateral prostate-confined disease, this cancer is T2c. Internal iliac, obturator, external iliac and sacral are
regional nodal groups. Common iliac, para-aortic and inguinal involved lymph nodes are regarded as metastases.
39) A 55-year-old man has biopsy-proven penis cancer. An MRI is performed. Which of the following is the best
reason for performing this examination?
a. to confirm the diagnosis
b. to refute the diagnosis
c. to perform local staging
d. to assess metastatic spread
e. to assess regional lymph node involvement
c. to perform local staging
MRI offers good soft-tissue contrast that is of value in local staging of the primary tumour. Local extent is used
to guide the type of treatment, which includes partial penile amputation, total penectomy and radiation therapy.
MRI will also show enlarged regional lymph nodes, but the principal purpose of MRI is local staging. CT can
also be used for nodal spread and metastatic disease
44) A 14-year-old boy slides off his saddle while cycling, injuring his testicles. On ultrasound scan, one testicle
has a paratesticular complex cystic mass, loss of testicular outline and several avascular planes within the testicle.
Which of the following is the most appropriate management?
a. discharge with analgesia
b. admission for analgesia
c. admission for elective surgery
d. admission for surgery the following day
e. immediate surgical intervention
e. immediate surgical intervention
Testicular rupture is described; it is an indication for immediate surgical intervention to salvage the testicle and
prevent anti-sperm antibody development (testicles are immune-privileged sites). Other consequences of
testicular trauma are fracture, haematoma and haematocele. Associated torsion may occur, due to traumastimulated, forceful, cremasteric muscle contraction.
46) A 35-year-old male is prompted to see his general practitioner by his wife, who has noticed blood in the man’s
semen. An ultrasound scan of the scrotum is performed. What is the most common appearance that would
accompany this symptom?
a. normal appearances
b. enlarged spermatic cord, epididymis and testicle with decreased echogenicity
c. testicular enlargement showing a hypoechoic lesion with a fluid–fluid level
d. paratesticular ‘bag of worms’ appearance
e. scrotal skin thickening
a. normal appearances
Investigation in most cases of haemospermia is not fruitful. In patients under 40 years, the causes are usually
idiopathic or inflammatory (prostatitis, epididymo-orchitis, urethritis and urethral warts). The same causes apply
in those over 40 years, but further possible causes include prostate cancer, benign prostatic hypertrophy, prostatic
or seminal vesicle calculi, hypertension and carcinoma of the seminal vesicles.
49) Into which of the following lymph node groups does lymph from the scrotum initially drain?
a. para-aortic at the L1–2 level
b. superficial inguinal
c. obturator
d. internal iliac
e. presacral
b. superficial inguinal
Testes drain to the para-aortic nodes at the L1–2 level. The penile body drains to superficial inguinal nodes, while
the proximal penis lymph drainage is to deep inguinal nodes. Appreciation of these patterns of lymph drainage is
of vital importance when staging testicular, penile and other scrotal malignancies
51) A 40-year-old man has a right-sided intratesticular mass of indeterminate ultrasound appearance. A CT scan
of the chest, abdomen and pelvis reveals an enlarged, round, cystic, right paracaval lymph node just caudal to the
right renal vein. Other enlarged cystic lymph nodes are demonstrated in the mediastinum. No enlarged suprarenal
or retrocrural nodes are seen. Considering these findings, which tumour type is most likely to be found in the
orchidectomy specimen?
a. epidermoid tumour
b. malignant teratoma
c. seminoma
d. metastatic lung squamous cell carcinoma
e. adenomatoid tumour
b. malignant teratoma
Seminoma tends to spread to contiguous nodes with the primary sites being, for a right-sided testicular tumour,
right paracaval and interaortocaval nodes just below the junction of the right renal vein and inferior vena cava.
Left-sided testicular tumours usually spread first to nodes just caudal to the left renal vein. Teratoma and other
malignant, non-seminomatous, germ cell tumours of the testes can occupy mediastinal nodes without such direct
cranial extension along the nodal groups. Nodes involved by seminoma tend to be soft-tissue density while nodes
inhabited by non-seminomatous, germ cell tumours are frequently cystic. Metastases to the testicle are rare on
account of the testicle being an immunologically privileged site with a blood–testicular barrier. Adenomatoid
tumour is a benign epididymal lesion. Epidermoid tumour is also benign, appearing as an intratesticular,
hypoechoic lesion, characteristically with an echogenic capsule. Classically, it assumes an ‘onion-skin’
appearance of concentric echogenic layers. Internal shadowing can be produced by calcification.
62) A patient with a raised PSA has MRI of the prostate. There is diffuse, low-signal change throughout the
peripheral zone on T2W images. At the right base, there is focal high signal on T1W images. At the left base
there is restricted diffusion. In the right mid-gland, spectroscopic analysis reveals a choline plus creatine/ citrate ratio of considerably less than 0.8. In the left mid-gland, there is a diminished contrast wash-in rate. At the apex,
the relative peak enhancement is less than in other regions of the prostate. Which is the most likely site of focal
prostate carcinoma?
a. left base
b. right base
c. left mid-gland
d. right mid-gland
e. apex
a. left base
In staging prostate cancer with MRI, the large-FOV T1W sequence is useful for demonstrating haemorrhage (high
signal), enlarged lymph nodes and bone metastases. Small-FOV T2W images of the prostate in axial, coronal and
sagittal planes show the zonal anatomy well, with normal peripheral zone returning high signal. Cancer within
the peripheral zone typically returns low signal on T2W images. Othertypical findings in carcinoma of the prostate
are increased relative peak enhancement, increased contrast wash-in rate, reversal of the choline plus
creatine/citrate ratio on spectroscopy, restricted diffusion and increase in permeability on pharmacokinetic
modelling
82) A 20-year-old man presents with a 4-week history of a scrotal mass. There has been no trauma and no pain.
Ultrasound scan confirms an intratesticular, partly cystic, heterogeneous mass. Which of the following tumour
markers is most likely to be elevated?
a. CA-125 and AFP
b. CA-15-3 and CEA
c. PSA
d. CA-19-9
e. AFP and b-hCG
e. AFP and b-hCG
The patient’s age and ultrasound findings favour a non-seminomatous germ cell tumour. These are associated
with elevated serum AFP and b-hCG. Together, CA-125 and AFP are associated with hepatocellular carcinoma,
while CA-125 is also associated with ovarian cancer. CA-15-3 and CEA together are serum markers associated
with breast cancer. PSA is associated with prostate cancer as well as several benign prostate conditions. CA-19-
9 is mainly associated with malignancy of the pancreas and biliary tree.
88) On MRI of the penis, a squamous cell carcinoma is typically seen as hypointense to the corpora on T1W and
T2W images. What is the most likely appearance of this cancer on T1W images following intravenous contrast
administration?
a. no change in signal compared with that on the pre-contrast T1W sequence
b. post-contrast enhancement greater than that of the corpus spongiosum but less than that of the corpora
cavernosa
c. post-contrast enhancement less than that of all corpora
d. post-contrast enhancement greater than that of all corpora
e. post-contrast enhancement greater than that of the corpora cavernosa but less than that of the corpus
spongiosum
c. post-contrast enhancement less than that of all corpora
Most cancers of the penis (95%) are squamous cell carcinoma, but basal cell carcinoma, sarcoma, melanoma,
lymphoma and urethral transitional cell carcinoma are also possible. Typical appearances of a primary penile
cancer are of an ill-defined infiltrating lesion hypointense to the corpora on both T1W and T2W images. Tumours
enhance following contrast, but to a lesser degree than the normal corporal bodies. Signal characteristics of
melanotic melanoma will be notably different from the other tumour types, returning a bright signal on T1W
images.