Malignant Disease and Immunosuppression Flashcards Preview

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Flashcards in Malignant Disease and Immunosuppression Deck (5)
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1

Anthracycline Antibiotics (Doxorubicin, daunorubicin): Mechanism of Action

They are cytotoxic antibiotics. They intercalate in DNA and prevent the progression of DNA topoisomerase II. This halts DNA synthesis.

2

Anthracycline Antibiotics (Doxorubicin, daunorubicin): ADRs

Alopecia
Doxorubicin is highly cardiotoxic
Extravasation causes local necrosis

3

Vinca Alkaloids (Vincristine, vinblastine): Mechanism of Action

They are spindle poisons. They bind to tubular and inhibit its polymerisation. Cell division is therefore arrested at mitosis. They are only active against dividing cells.

4

Vinca Alkaloids (Vincristine, vinblastine): ARDs

Mild myelosuppression
Neurotoxicity: parasthesia, weakness
Abdominal pain

5

Purine analogues (mercaptopurine): Mechanism of Actoin

It is converted into a fraudulent nucleotide