Malik: COPD, Asthma, Mucolytic Rx Flashcards Preview

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Flashcards in Malik: COPD, Asthma, Mucolytic Rx Deck (74):

What AE's are associated with the methylxanthines?

- 5μg - 10μg/mL serum levels may cause nausea, vomiting, nervousness, headache and insomnia

- Serum levels > 20μg/mL cause vomiting, hypokalemia, hyperglycemia, tachycardia, cardiac arrhythmias, tremor, neuromuscular irritability and seizures 

- May have beneficial effects in asthmatics or COPD pts resistant to glucocorticoids 

- CYP450 metabolism -> narrow therapeutic index due to cardio- and neurotoxicity


What does histamine do? How? What are the 1st and 2nd gen anti-histamines?

- Histamine released from mast cells and also produced in various tissues -> exerts many bio actions via stimulation of 4 subtypes (H1-H4

- Stimulation of H1 receptors by histamine results in: 

1. Allergic and inflammatory responses

2. Bronchoconstriction

3. Vasodilation and increased vascular permeability

4. Urticaria: wheel and flare reactions

- 1st gen (sedative effects): Chlorpheniramine, Diphenhydramine, Promethazine

- 2nd gen (no sedative/CNS effects): Fexofenadine, Loratidine, Cetirizine

- NOTE: we will have another lecture on this 


Why are beta agonists more effective than anti-cholinergic drugs in preventing bronchospasm?

- While there is no direct SYM innervation to the bronchial smooth muscle, this muscle does have the highest density of B2 receptors (especially in the bronchioles, vs. the trachea and upper airways for muscarinic receptors) 

- NOTE: epinephrine is the endogenous ligand that stimulates B2 (NOT norepinephrine) 


What is the MOA of N-Acetyl Cysteine? What is it used for?

- Breaks mucoprotein bonds by substituting a sulfhydryl radical (-HS) 

- Given by aerosol or direct instalation into the ET tube 

- Given orally to reduce liver injury with acetaminophen (Tylenol) overdose -> mix w/cola or given by nasogastric (NG) tube 

1. Increases precursor to glutathione

- Alternatives: Acetadote, Erdosteine, Carbocysteine


What are some of the non-pharmacologic tx's for cough (5)?

- Eliminating irritants 

- Hard candies (i.e., jolly ranchers) 

- Lozenges 

- Humidifiers or vaporizers 

- Hydration


What are the treatment options for COPD?

- Smoking cessation: nicotine replacement therapy

1. Bupropion (Wellbutrin: atypical anti-depressant that blocks nicotine receptors) +/- nicotine patch

- Bronchodilators: β2-Adrenergic receptor agonists

1. Short-acting to relieve acute symptoms: Albuterol or Terbutaline (IV)

2. Long-acting: 12-hr -> Salmeterol + Fluticasone, Formoterol + Budesonide; 24-hr -> Indacaterol, Vilanterol + fluticasone

- Anti-muscarinic agents

1. Ipratopium (M2, M3; 4-5 hr)

2. Tiotropium (M3; 24 hr)

3. Umeclidinium bromide (M3 -> not selective for M3, but only binds to M2 for short time; 24 hr)

4. Umeclidnium/Vilanterol (β2 Agonist + M3; 24 hr)

- Theophylline and derivatives

1. Theophylline recruits HDAC2, reducing formation of 3-nitrotyrosine (anti-inflammatory effects at doses less than those required to inhibit PDE) 

2. HDAC2 activity DEC w/high oxidative stress (smoke) 

Additional options:

1. Combo therapy of bronchodilators

2. Corticosteroids

3. Oxygen Therapy

4. Mucolytics (N-acetylcysteine: breaks down mucus)

5. Guaifenesin (expectorant -> Robitussin): stimulates the flow of respiratory tract secretion

6. Surgical treatment, incl. lung volume reduction or lung transplant  


What are Zafirlukast and Monteleukast?

Block LTD4 receptors

- DEC bronchial reactivity and bronchoconstriction

- DEC mucosal hypersecretion and mucosal edema

- DEC airway inflammation

- Aspirin-induced asthma: "effective in some patients

1. Aspirin blocks COX, shunting everything to the LT pathway in aspirin-induced asthma 

- NOTE: Zafirlukast not used as much as Monteleukast (Singulair)


What are the side effects and contraindications for Dextromethorphan?

Side effects: dizziness, drowsiness, nausea, vomiting, upset stomach, diarrhea, irritability, excitability, light headedness, and trouble sleeping

Contraindications: peeps on monoamine oxidase inhibitor (MAOI) anti-depressants (INC Serotonin can be dangerous -> teen girl example w/OTC meds), advanced respiratory insufficiency (ARDS), hepatic disease, hypersensitivity to any of the ingredients of the product


What are the 2 oral (systemic) decongestants?

- Pseudoephedrine (Sudafed): indirectly-acting sympathomimetic 

1. Releases NE from adrenergic NN (enters N, takes NE to synaptic cleft -> does not stimulate directly)

2. Minorly metabolized via N-demethylation to nor-pseudoephedrine (up to 88% of dose excreted in 36-hr urine) -> better bioavailability than phenylephrine (100% vs. 38%)

- Phenylephrine: directly stimulates alpha-adrenergic receptors on post-synaptic sites (ALPHA-1 selective)

1. Rapidly metabolized by MAO and COMT in GI mucosa, liver, and o/tissues 

- NOTE: both drugs have a short half-life (peak: 0.5-2 hrs)


What are the pharmacologic tx options for cough?

- Antitussives: drugs of choice 4 non-productive cough 

1. Systemic agents:

a. Dextromethorphan

b. Diphenhydramine

c. Codeine 

2. Topical agents

a. Camphor

b. Menthol

- Expectorants: DOC for productive cough with thick secretions -> Guaifenesin


What is COPD?

- Progressive loss of airflow in lungs, resulting in broncho-constriction that is not fully reversible

1. Primarily caused by chronic inflammation -> two common forms are bronchitis and emphysema

- Elastic parenchymal tissue is replaced by inelastic fibrotic tissue such that elastic recoil of lung is lost

1. Collapse of airways mid-exhalation leads to air trapping, loss of capacity and, in some cases, impaired gas exchange 


What is Dextromethorphan?

- MOA: suppresses cough reflex by direct action on cough center in the medulla of the brain 

- Metabolized via CYP2D6 (same as codeine) into dextrorphan -> as active as parent drug

- Nonopioid, but equal potency to codeine

1. Onset: 15-30 min; duration: 3-6 hours

2. Wide margin of safety -> lg doses (12-75x TD doses produce dissociative hallucinogenic effect via INC serotonin)

a. Used recreationally -> may cause liver toxicity if abused if mixed w/acetaminophen

- Active ingredient in many cold/cough meds: Mucinex, Robitussin, NyQuil, Vicks, Dimetapp 


What are some non-pharmaceutical ways to reduce mucus?

- Provide adequate hydration: increase fluid intake PO or IV 

- Remove causative factors: smoking, pollutants, allergens 

- Optimize tracheobronchial clearance 

- Reduce inflammation


What are the advantages/disadvantages of sprays vs. drops?


1. Advantages: fast onset, inexpensive, easy to use, cover large SA

2. Disadvantages: imprecise dosage, tip tends to get blocked 


1. Advantages: for small children

2. Disadvantages: awkward to use, cover limited SA, pass easily into larynx, easily contaminated if dropper touches nose


Briefly describe the neural pathways for cough.

- Cough receptors (red) at airway bifurcations in the larynx and at the distal esophagus link to cough afferents through the vagus and superior laryngeal nerves to the cough center and cerebral cortex 

- Efferent pathways coordinate the muscle response that leads to cough



What are the steps of asthma therapy for those >= 12 y/o (chart)?

- Note: LTRA = leukotriene receptor antagonist


Briefly describe what is going on at a molecular level in the nasal mucosa, and how we control that.

- Nasal mucosa highly vascularized

- Allergic activation of mast cells: release PGD2, LT's, & histamine (can act on sensory fibers) -> INC bradykinin

- Message carried to brain -> INC PARA activity and DEC SYM, so INC secretion of mucosal glands

1. Reduced release of NE, causing vasodilation (via histamine, bradykinin, substance B, and CGRP bc no PARA innervation to blood vessels), congestion

- Steroid sprays can reduce the inflammation, but anti-histamines needed and vasoconstrictive agents needed to DEC vasodilation -> vasoconstrictive agents DO NOT affect release of histamine, but are often COMBINED with anti-histamines


What is the Cushingoid syndrome?

- Weight gain, esp abdomen, face (moon face), neck, and buffalo hump

- Thinning and leg/arm muscle weakness

- Thin skin, with easy bruising and stretch marks

- INC acne, facial hair growth, and scalp hair loss in women

- Ruddy complexion on the face and neck

- Often a neck skin darkening (acanthosis) 

- Child obesity and poor growth in height

- High Blood pressure (usually) 


Why are nicotinic receptors important?


- Nicotinic receptors can directly polarize the nerve terminal and cause release of Ach, i.e., nicotine from smoking 

1. The only receptor that will block ganglionic transmission is the nicotinic receptor 



How do sympathomimetics act in the nasal cavity? What are the dosage forms?

- Sympathomimetics: stimulate adrenergic receptors directly or indirectly 

- Stimulation of alpha-adrenergic receptors constricts blood vessels throughout the body 

1. Reduces supply of blood to the nose 

2. DEC amt of blood in sinusoid vessels 

3. DEC mucosal edema 

- Dosage forms: oral (systemic), topical, intranasal sprays, inhalation


What are the 3 expectorants?

- Iodines-iodinated glycerol (Expigen): unclear function, but can increase the production of serosal, watery fluid

1. Saturated solution of potassium iodide (SSKI)

Guaifenesin (Mucinex): at high doses, stimulates bronchial gland secretion 

Bromohexine (Bisolvon): secretolytic, INC production of serous mucus in resp tract and DEC viscosity of phlegm 


What is Codeine? Side effects and contraindications?

- Opioid analgesic and antitussive related to morphine 

- Depresses cough reflex via direct action on cough center in the CNS (also mu receptors; 

- Onset: 10-30 min; duration: 4-6 hrs 

- About 10% of codeine metabolized to morphine and other products (CYP2D6); ingredient in many syrups

1. Can’t use in children (metabolism may vary) 

2. If high conc of this enzyme, more of the drug will be metabolized to morphine, which has a higher incidence of respiratory depression

Side effects: CONSTIPATION, SEDATION, histamine release, vasodilation, orthostatic hypotension, dizziness, RESPIRATORY DEPRESSION (CAPS = all opioids cause) 

Contraindications: hypersensitivity, labor of premature birth, pregnancy category C (cranial malformations in animal studies), prostatic hypertrophy, peeps on sedatives, pts w/resp depression, asthma, COPD, post-tonsillectomy or adenoid sx (lymph tissue back of neck)


What is non-productive cough? What things cause it?

- Dry hacking cough that does not remove sputum from the respiratory tract 

1. Viral illness 

2. Bronchospasm 

3. Allergies 

4. Asthma

5. Airway obstruction

6. GERD: acid can go all the way down into the larynx, and activate those receptors too


What are mucolytics? When are they used?

- Promote the breakdown of mucus: 

- Used in diseases with INC mucus production: 

1. Cystic fibrosis 


3. Bronchiectasis

4. Respiratory infections: TB


What are the AE's for Cromolyn?

- No systemic toxicity

- Unpleasant taste

- Irritation of trachea -> cough, and bronchospasm can occur after inhalation

- Rare AE's: chest pain, restlessness, hypotension, arrhythmias, nausea, vomiting, CNS depression, seizures and anorexia 


What is productive cough? What types of secretions are possible?

- Wet cough with secretions 

1. Clear - bronchitis 

2. Purulent - bronchial infection 

3. Yellow - inflammatory disorders 

4. Malodorous - anaerobic infection


What are the B2 agonists? SABA? LABA?

- SABA: rescue medication; quick onset, and intermediate duration (3-6 hours)

1. Albuterol

2. Xopenox (R-isomer or albuterol)

3. Terbutaline (IV: ICU settings) 

- LABA: used only in combo w/inhaled steroids; slower onset, and long duration (6-12 hours)

1. Salmeterol xinofoate, Salmeterol + Fluticasone

2. Formoterol fumarate, Formoterol fumarate + Budesonide, Formoterol + Mometasone


What are bland aerosols? What are some types?

- Dilute the mucus molecules, aka, wetting agents (function may be more of an irritant than a wetter) 

- Types: 

1. Sterile/distilled water: humectant, dense aerosols

2. Normal (isotonic) saline 

3. Hypertonic saline: INC mucus production

4. Hypotonic saline 


What are some of the complications of cough?

- Exhaustion 

- Urinary incontinence 

- Pain 

- Insomnia

- Syncope

- Stroke

- Rib fractures 


What are nasal decongestants?

- Vasoconstrictive drugs that reduce nasal congestion 

- Don't affect release of histamine or any other mediators involved in allergic reaction 

- Commonly formulated w/anti-histamines


What is Omalizumab? How is it administered/dosed?

- Anti-IgE monoclonal Ab: binds to IgE and prevents IgE-instigated release of inflammatory mediators (IV admin)

1. Decreases allergic response

- Reduces severity & frequency of asthma attacks

- Reducces requirement of inhaled corticosteroids -> better long-term asthma control (used in pts resistant to corticosteroids)

- Binds to the allergen binding site to prevent allergen from stimulating a response

- Administered every 2 or 4 weeks; dose based on weight


What are the two topical nasal decongestants?

- Oxymetazoline (0.05%): OTC direct alpha-1 adrenergic agonist 

1. Do NOT use for more than 3-5 days (Afrin, Zicam) 

2. Preferred topical agent in pregnancy 

Phenylephrine: nasal spray (Vicks), nose drops, Sudafed

- Include: sprays, drops, inhalers



What are some of the adverse reactions with the sympathomimetics (B2 agonists)?

- Nausea, vomiting and headache

- Fall in BP, INC HR, and cardiac arrhythmias

- Hypokalemia -> QT prolongation

- Arterial oxygen tension (PaO2) may decrease

- CNS toxic effects, including: agitation, convulsions, coma and respiratory and vasomotor collapse


What is the one FDA approaved expectorant? Side effects and contraindications?

- Guaifenesin (Mucinex): symptomatic relief of ineffective, productive coughs (chest congestion) 

1. Loosens and thins LRT secretions by INC volume and DEC viscosity of secretions 

- NOT used for chronic coughs

- Vets: used to induce/maintain anesthesia in horses and llamas 

Side effects: dizziness, dry mouth, rash, diarrhea, drowsiness, nausea, vomiting, stomach pain, uric acid nephrolithiasis in high doses (rare)

Contraindications: hypersensitivity 


What are the therapeutic uses and AE's of the anti-histamines?

Therapeutic uses

1. Common cold, seasonal allergic rhinitis (hay fever), pruritis, urticaria, anaphylaxis, nausea, vertigo, motion sickness 

2. To reduce tension, anxiety, and promote sleep, sedation

3. Atopic dermatitis, sinusitis, and allergic rhinitis

- Side effects: sedation, dizziness, impaired motor function, blurred vision, dry mouth and throat, constipation, urinary retention (anti-muscarinic effects) 


What are the side effects and contraindications for Dornase alfa (Pulmozyme)?

- Side effects

1. Voice alteration 

2. Pharyngitis/laryngitis 

3. Rash 

4. Chest pain

 5. Conjunctivitis 


1. Pts hypersensitive to Chinese hamster ovary cells (used to produce many of the Abs, i.e., EPO -> there are people who are very sensitive to these products, like Omalizumab)


Atropine sulfate and Ipratroprium

- Aka, Atrovent -> competitive Ach-muscarinic receptor blockade:

1. Reduce airway smooth muscle constriction

2. Decrease in mucous secretion

3. Enhance β2-mediated bronchodilation

AE's: pupillary dilation and cycloplegia, on contact

1. Cycloplegia: paralysis of ciliary muscle of the eye, so loss of accommodation -> curvature of the lens can no longer be adjusted to focus on nearby objects

2. -Ipratropium, a quaternary compound, is poorly absorbed with no significant systemic effects 

- Ipratropium: break a capsule and put it in bronchodilator (do not want to touch your eyes after doing this) 


What is the difference between acute, subacute, and chronic cough?

- Acute: lasting less than 3 weeks 

- Subacute: one to eight weeks 

- Chronic: >8 weeks


What are the pharmacological actions of the glucocorticoids?

- Pharmacological actions:

1. DEC production of inflammatory cytokines

2. Reduce mucus secretion

3. Reduce bronchial hyperactivity

4. Enhance the effect of β-2 adrenergic agonists 

- NOTE: these are the -sones and -nides 

1. Ciclesonide is a short-acting, "soft" steroid


What are the actions of the methylxanthines?

- INC levels of cAMP (inhibiting PDE)

- Block muscle adenosine (A3) receptors

1. Adenosine is a breakdown product of ATP w/INC levels in asthmatics -> stimulates release of histamine from mast cells (via A3 receptors)

- DEC release of mediators

- Bronchodilation

- Anti-inflammatory effect

- + inotropy (strength of contraction) & chronotropy (rate)

- INC CNS activity

- INC gastric acid secretion

- Weak diuretic effect

- INC skeletal muscle strength (diaphragm) 


What causes bronchoconstriction at a molecular level? How does asthma affect this?

- Damage to the epi lining or Trp channels activated by irritants/particles -> activation of the M receptors and more release of Ach to try and clear the irritant

- In asthmatics, the M2 feedback receptor is also dysfunctional (due to excess major basic protein from eosinophils) 

- All of this leads to BRONCHOCONSTRICTION 



Define cough and its phases.

- 3-phase expulsive motor act

1. Inspiratory effort (inspiratory phase) 

2. Forced expiratory effort against a closed glottis (compressive phase); associated with a characteristic sound

3. Opening of the glottis and rapid expiratory airflow (expulsive phase) 




- INH leukotriene (LTB4, LTC4, LTD4, and LTE4) formation

- DEC smooth muscle contraction, blood vessel permeability, and leukocytes migration to damaged area

- AE's: hepatic enzyme elevation (LFT's required)

1. CYP1A2 substrate and inhibitor – interaction with theophylline (among others)

2. Most other effects mild and self-limiting

- Under evaluation for other inflammation-related diseases like rheumatoid arthritis, ulcerative colitis and acne 


What are the differences between asthma and COPD (chart)?



What is the MOA of sodium bicarbonate?

- 2% NaHCO3 solutions used to increase the pH of mucus -> weakens the carbohydrate (polysaccharide) side chains 

- Can be injected directly into the trachea and aerosolized (2-5 mL) 

- Mix 5% solution w/equal volume of sterile water

- Can be irritating 


What is primatene mist?

- Epinephrine (B1, B2, A): 30-90 min duration 

- No longer on the market 


What does Theophylline do?

- Phosphodiesterase inhibitor (PDE): reduces rate of degradation of cAMP 

- Also blocks the adenosine receptor


What are the AE's of Zafirlukast and Monteleukast?

- ZafirlukastG.I.T. disturbances, mild headache, elevation of liver enzymes in some patients

1. High doses in rodents have caused hepatic and bladder cancer and histocytic carcinoma (have not been observed in humans)

- MonteleukastG.I.T. disorders, laryngitis, pharyngitis, nausea, otitis, sinusitis, and viral infections (URI's) with a frequency of 2% and more frequently in pediatric patients

1. Possible association between suicidal ideation and monteleukast is being investigated 

2. Higher doses of this drug have NOT been found to be tumorigenic in rodents


Where do steroids, Zileuton, and Zafirlukast act on the AA pathway?

- Steroids stimulate synthesis of lipocortin and macrocortin that inhibit the functioning of PLA2 

- Zileuton inhibits LT synthesis 

- Zafirlukast is a competitive INH for LTC4, D4, and E4

- See image


What are the AE's and contraindications for Omalizumab (Xolair)?

Serious allergic reactions: difficulty breathing, closing of throat, swelling of face, lips or tongue, and hives

- Less serious effects: redness, bruising, warmth, burning, stinging, itching, pain or inflammation at injection site or sore throat or cold symptoms

1. If you inject > 150 mg, you have to use more than one injection site 

- Initial concerns for tumors

- INC in CV complications: MI, CAD, arrhythmias (no causative association)

- Contraindications: no known drug interactions, but avoid concurrent agents (prescription OTC, vitamins, herbals)


What is the MOA of the sympathomimetics?

- Bronchodilation is caused by increased levels of cAMP

1. IC levels of cAMP INC by beta-2 adrenoceptor agonists -> INC rate of its synthesis by adenylyl cyclase (AC)



What is the proposed mech of corticosteroid action to suppress TH2 cell cytokine synthesis in allergic disease?

- Reduce transcription and production of IL-4, 5, and 13 (TH2 cytokines)

- Compete with GATA-3 for its transport in the nucleus by binding with importin-alpha and importin-13 

1. Phosphorylation of GATA-3 results in its transport into the nucleus, but glucocorticoids prevent this by competitive inhibition 

2. Go to the nucleus and INH NFkB, DEC transcription of inflammatory genes, INC transcription of anti-inflam genes, and DEC mRNA stability of inflam cytokines (i.e., TNF-alpha, GM-CSF, IL-6, and COX-2)



What are the structure and composition of mucus?

- Glycoprotein: large macromolecules 

1. Strands of polypeptides (protein) make up backbone -> string of AA's 

2. Carb side chains 

3. Chem bonds hold mucus together 

a. Intramolecular: dipeptide links (connect AA's) 

b. Intermolecular: disulfide and H-bonds: connect adjacent macromolecules 


What drugs are contraindicated in airway disease?

- Sedatives: depress respiration 

- Beta-blockers

- Aspirin and other cyclooxygenase inhibitors

- Angiotensin-converting enzyme inhibitors (ACEI's): ACE (kininase 2) also degrades bradykinin -> accumulation of bradykinin causes stimulation of sensory nerves and makes PGE2, which also causes this stimulation 


What is Cromolyn sodium?


- Pharmacological actions

1. May alter the activity of chloride channels

2. INH degranulation of mast cells in the lung, thereby inhibiting histamine release

3. INH inflam response by acting on eosinophils

4. Inhibit cough by their action on airway nerves

5. Reduce bronchial hyperactivity associated with exercise- and antigen-inhaled asthma 

- Prophylactic in some individuals (but may take 2-3 weeks to start working) 

- Inhaler, nasal spray, eye drops


What are the methylxanthines?

- Related to caffeine -> PDE and adenosine inhibitors

1. Aminophylline 

2. Theophylline 

3. Diphylline 

4. Oxtriphylline 



What is Combivent? Why use it?

- Inhaler to be taken at home that is a combo of Ipratropium and Albuterol (anti-cholinergic + beta-2 agonist)

- Combined therapy produces a greater improvement in lung function than either ipratropium or albuterol alone

- Indicated for COPD 


What are some key AE's with Albuterol and LABA's?

- Albuterol: can cause tremors (inhibit Na/K ATPase) 

- LABA’s: black-box warning that may increase mortality for patients with asthma (when used alone) 


What are the 2 beta-agonist signalling pathways? Why is this important?

- Biased agonists -> want to isolate the classical signaling model (there are many different conformational states) 

1. Classical: B2 receptor -> G protein -> adenylyl cyclase -> cAMP = DEC Ca + activated PKA (both of which inactivate myosin light chain kinase and activate myosing light chain phosphatase) 

A. Combo of DEC IC Ca, INC membrane K conductance, and DEC myosin light chain kinase activity = smooth m. relaxation + bronchodilation

2. Alternative signalling (on the R): can lead to inflammation 

- Also REMEMBER: Ca -> calmodulin -> INC MLCK -> constriction (so Ca sequestration in the classical pathway also encourages relaxation of smooth muscle) 


How is Amiloride used as a decongestant?

- Diuretic that can be given as an aerosol to pts with cystic fibrosis 

- Na+ channel blocker: in CF, Na+ absorbed into epi along w/H2O, leaving mucus thick and dehydrated -> by blocking Na+ absorption, deyhydration of the mucus is prevented 

- Drug dissolved in 0.3% NaCl solution, and nebulized 

- Not very effective 


What are the 2 sympathomimetic inhalers?

- Levamfetamine (Vicks Vapor; 50 mg): same actions as PE

1. No nasal rebound for 7 days 

2. Labelin advises to see MD if symptoms persist >3 days

Propylhexadrine (Benzadrex; 250 mg): releases NE from SYM NN -> a little less effective than PS, and can have hallucinogenic effect at high doses

1. Abused (cotton plug ingested or injected)


What are the side effects of the systemic decongestants?

- CV stimulation

1. PE = reflex bradycardia due to INC BP (INC PARA, DEC SYM)

2. PS = INC BP, tachycardia, palpitations, arrhythmias

- CNS stimulation

1. PS = restlessness, insomnia, tremors, anxiety, fear, hallucinations

- Cause of rebound congestion: ischemia (or necrosis) bc of local vasoconstriction or irritation of drug (esp. PE)

- Children/elderly more likely to experience AE's


Briefly, what do LTB4, C4, D4, and E4 do?

- Do NOT memorize this pathway; FLAP leads to 5-HPETE synthesis, followed by LT synthesis 

- LTB4: neutrophil chemoattractant

- LTC4 & LTD4 (and E4?): mimic many symptoms of asthma

1. Bronchial hyper-reactivity, bronchoconstriction (WAY MORE POTENT THAN HISTAMINE), mucosal edema, and increased mucus secretion 


What is Dornase alfa (Pulmozyme)? What are its indications?

- Clone of the natural human pancreatic DNAse enzyme, which digests EC DNA (solution of recombinant human DNAse)

- Reduces viscosity of secretions during infection by breaking down EC DNA 

- Indications: cystic fibrosis (maintenance therapy), chronic bronchitis, or bronchiectasis 

1. Has no effect on non-infected sputum 


What are the precautions and contraindications for PS and PE?

- Children and elderly 

Hyperthyroidism: INC expression of beta-adrenergic receptors in heart -> never give agents that INC NE levels 

- Bradycardia (PE) 

Partial heart block (PE): INC vagal activity can cause heart block

- Hypersensitivity

- Uncontrolled HTN 


What are the side effects and precautions for N-acetyl cysteine?

- Bronchospasm:

1. Asthma -> may be a problem during an acute asthma attack (anecdotal; lack of evidence) 

2. If used with asthma, use 10% and mix w/a bronchodilator (preferably, short-acting)

- Increased mucus production: be prepared to suction a pt. who cannot cough or who is intubated 

- Do not mix w/AB's in the same nebulizer (incompatible)

- Nausea and vomiting

- Disagreeable odor (smells like rotten eggs) due to the hydrogen sulfide 

- Open vials should be used w/in 96 hrs to prevent contamination  


What are Camphor and Menthol? What are their MOA's? How are they given?

- Camphor: acts on TRPV1 channels, desensitizing them, and leading to soothing effect (also TRPA1 channels) 

Menthol: cooling sensation (Na+ channels); TRPM8 activation and desensitization -> pretty effective in some peeps

- Rub on throat, chest in thick layer (repeat TID; NOT in nostrils, nose, or mouth) 

- Also eucalyptus, menthol lozenges (allow to dissolve slowly & repeat hourly/PRN), camphor or menthol inhalation (breathe in medicated vapors to TID) 


What are the pharmacological actions of the sympathomimetics (B2 agonists)?

- Produce bronchodilation by INC levels of cAMP

1. ATP -> cAMP -> PKA -> bronchodilation + vaso-dilation in muscle 

- Exert some INH effect on release of mediators from mast cells (and o/cell types -> B2 receptors on inflam cells) 

- Also some inhibitory effect on microvascular permeability

- Stimulate to a small degree mucociliary clearance

- LABA may also increase transcription of glucocorticoid receptors 


What is Diphenhydramine? Side effects and contraindications?

- Anti-histamine: H1 receptor antagonist + suppresses cough reflex via driect action on cough center

- Antitussive effects due to anti-cholinergic effects 

- Onset: 15 min; duration: 4-6 hrs 

- 2nd line agent: indicated for non-productive cough caused by irritation 

- Other uses: common cold, allergic rhinitis, chronic urticaria, motion sickness, parkinsonism, insomnia 

Side effects: drowsiness, respiratory depression, blurred vision, dry mouth, urinary retention, constipation

Contraindications: prostate hypertrophy, urinary obstruction, asthma, COPD, peptic ulcer, MAOI's


What is Doxapram?


- Activates peripheral carotid receptors

- For use in

1. Post-anesthesia respiratory depression

2. Drug-induced respiratory depression

3. Acute hypercapnia in COPD


- Narrow margin of safety because it can cause seizures, increase BP, HR, and cause arrhythmias 

- Short-acting, and given by infusion (IV)


What are the AE's of the inhaled vs. oral glucocorticoids?

- Inhaled: oropharyngeal candidiasis, hoarseness, and dry mouth 

1. DEC bone mineral density in premenopausal F

2. DEC rate of growth in children

- Oral: prolonged use

1. Glucose intolerance

2. INC BP & weight

3. Bone demineralization

4. Cataracts

5. Immunosuppression

6. Retarded growth in children 


Tiotropium (Spiriva)

- Quarternay ammonium

- Once daily, like an inhaler -> capsule that rattles when you breathe in (long-acting: 24-hr)

- Competitive Ach-muscarinic blockade: mainly M3 receptors

- Poorly controlled asthma pts on inhaled glucocorticoids and LABAs -> Tiotropium reduces severe exacerbations and results in sustained bronchodilation

- AE's: same as Ipratropium (eye biz)


What is Denufosol tetrasodium?

- Enhance mucosal hydration and mucus clearance by activating Cl- secretion and inhibiting epi Na+ transport via activation of P2Y2 receptors -> receptors for ATP

1. ATP is usually released during inflammation, and can cause sensitization and mucus accumulation

- Has been granted a "fast track" designation for the tx of CF, and orphan drug status in the US and Europe 



Where are the muscarinic receptors in the lung?

- M1, M3: mucosal cells

- M2, M3: bronchial smooth muscle 

- M2 receptors also on NN terminal -> Ach (-) feedback