management of thyroid nodules Flashcards

1
Q

are solitary thyroid nodules usually malignant or benign?

A

95% benign

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2
Q

what are benign solitary thyroid nodules usually?

A
  • cysts
  • colloid nodules
  • benign follicular adenoma
  • hyperplastic nodule
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3
Q

what is the most common cause for a malignant solitary thyroid nodule?

A
  • papillary thyroid carcinoma (80%)
  • follicular thyroid carcinoma (10%)
  • medullary thyroid carcinoma (3%)
  • lymphoma (<5%)
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4
Q

what are indications to the nodule being in the thyroid?

A

-if it moves on swallowing

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5
Q

if a solitary thyroid nodule is painful what may this suggest?

A

-pain is an uncommon feature and is usually cause by intra thyroidal bleed into a cyst

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6
Q

what investigations should be done if a solitary nodule in the thyroid is found?

A
  • TSH levels

- USS FNA

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7
Q

what does Thy2 on FNA indicate?

A

benign

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8
Q

what does Thy2 on FNA indicate?

A

benign

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9
Q

what does Thy3 on FNA indicate?

A

its atypical

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10
Q

what does Thy4 on FNA indicate?

A

probably malignant

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11
Q

what does Thy5 on FNA indicate?

A

malignant

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12
Q

what does U2 on USS of a solitary thyroid nodule indicate?

A

benign

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13
Q

what does U2 on USS of a solitary thyroid nodule indicate?

A

benign

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13
Q

what does U2 on USS of a solitary thyroid nodule indicate?

A

benign

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14
Q

what does U3 on USS of a solitary thyroid nodule indicate?

A

atypical

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15
Q

what does U4 on USS of a solitary thyroid nodule indicate?

A

probably malignant

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16
Q

what does U5 on USS of a solitary thyroid nodule indicate?

A

malignant

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17
Q

what would treatment be if someone was a high risk group and had differentiated thyroid cancer? (DTC)

A

total thyroidectomy

consider radio-active iodine

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18
Q

what would treatment be if someone was a low risk group and had differentiated thyroid cancer? (DTC)

A

thyroid lobectomy

19
Q

what age would be considered low/high risk?

A

low risk <50

high risk> 50

20
Q

what tumour size would be considered low/high risk?

A

low<4 cms

high> 4cms

21
Q

what is the TNM classification for a tumour size 2cm of less?

22
Q

what is the TNM classification for a tumour size >2 cm but 4 cm or less and limited to the thyroid?

23
Q

what is the TNM classification for a tumour size >2 cm but 4 cm or less and limited to the thyroid?

24
what is the TNM classification for a tumour >4cms but limited to the thyroid or with minimal extrathyroidal extension (e.g. to stenothyroid muscle or perithyroid soft tissues)?
T3
25
What is the TNM classification for moderately advanced disease; tumour of any size extending beyond the thyroid capsule to invade subcutaneous soft tissues, larynx, trachea, oesophagus, or recurrent laryngeal nerve?
T4a
26
what is the TNM classification for very advanced disease; tumour invades prevertebral fascia or encases carotid artery or mediastinal vessels?
T4b
27
what is the TNM classification for very advanced disease; tumour invades prevertebral fascia or encases carotid artery or mediastinal vessels?
T4b
28
what is the TNM classification for no regional lymph node metastasis?
N0
29
what is the TNM classification for regional lymph node metastasis?
N1
30
what is the TNM classification for regional lymph node metastasis?
N1
31
what is the TNM classification for metastases to level VI (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes)?
N1a
32
what is the TNM classification for metastases to unilateral, bilateral, or contralateral cervical (levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (level VII)?
N1b
33
what is the TNM classification for no distant metastases found?
M0
34
what is the TNM classification for distant metastasis present?
M1
35
how may follicular thyroid carcinoma spread?
haematogenous spread
36
what is the most common type of follicular thyroid cancer?
minimally invasive follicular thyroid cancer
37
how is minimally invasive follicular thyroid cancer treated?
-usually with a thyroid lobectomy if significant vascular invasion then consider a total thyroidectomy
38
what disease is thyroid lymphoma associated with?
auto immune hypothyroidism (hashimotos)
39
how does thyroid lymphoma usually present?
-rapid onset of mass in thyroid usually in females aged 70-80
40
how is a thyroid lymphoma diagnosed?
-core biopsy for histological diagnosis
41
how is thyroid lymphoma treated?
Chemo (R-CHOP) | DXT or steroids
42
what does medullary thyroid carcinoma secrete?
calcitonin
43
what are types of medullary thyroid carcinoma?
- sporadic MTC - familial non MEN - femilial MEN (MEN2a)
44
what should be done if a patient is found to have multinodular goitre?
- assess function - assess structure - check TSH - CT scan
45
what is the treatment for multinodular goitre?
- most can leave - RAI (radioactive iodine if sign of hyperthyroid) - surgery if structural problem
46
who with a retrosternal goitre should be offered surgery?
- Lifestyle interfering symptoms - Possibility of cancer - Significant tracheal compression (?<7 mm) if symptomatic - Tracheal Flow Loops if other respiratory potential causes of orthopnoea/breathing difficulties - Audible Stridor