Marek's Disease & Lymphoid Leukosis

Question 1

A highly contagious viral disease of Poultry characterized by enlargement of the nerves and tumors on visceral organs, skin, and muscle.

Answer 1

Marek’s Disease(Fowl Paralysis)

Question 2

Most important natural host for Marek’s Disease virus

Answer 2

Chickens

Question 3

Marek’s Disease Virus is caused by?

Answer 3

Gallid alphaherpesvirus 2(Marek’s Disease virus 1)

Question 4

Three serotypes of Marek’s Disease virus:

Answer 4

Gallid alphaherpesvirus 2(MDV serotype 1)
Gallid alphaherpesvirus 3(MDV serotype 2)
Meleagrid alphaherpesvirus 1 (turkey herpesvirus, MDV serotype 3)

Question 5

One of the most ubiquitous avian infections ; it is identified in chicken flocks worldwide

Answer 5

Marek’s Disease

Question 7

MDV matures into a fully infective, enveloped form in the?

Answer 7

Epithelium of the feather follicle

Question 8

MDV transmission occurs by

Answer 8

Respiratory route

Question 9

Marek’s Disease can develop in Chickens as young as

Answer 9

3 weeks old

Question 10

Four phases of infection with Marek’s Disease are recognized:

Answer 10

Early cytolytic infection
Latent infection
Second phase of cytolytic
Proliferative phase

Question 11

The incidence of Marek’s Disease depends on the following factors:

Answer 11

Strain and dose of virus
Age at exposure
Maternal antibody
Host sex and genetics
Strain and dose of vaccine virus
Several environmental factors, including stress

Question 12

Im addition to lymphoid neoplasms, Marek’s Disease virus can also induce other clinically distinct disease syndromes, including the following:

Answer 12

Transient paralysis
Early mortality syndrome
Cytolytic infection
Atherosclerosis
Persistent neurologic disease

Question 13

Lesions in MDV:

Answer 13

Enlarge nerves
Various peripheral nerves
Diffuse or nodular lymlhoid tumors
Enlarged feather follicles

Question 14

MDV Diagnosis standard criteria:

Answer 14

History and Clinical signs

Gross pathological findings
Histological examination

Question 15

MDV Diagnosis advanced criteria:

Answer 15

Immunohistochemical testing
Standard and quantitative PCR assay
Virus isolation
Serological Testing

Question 16

MDV Most widely used vaccines include the following:

Answer 16

Turkery herpesvirus
SB-1 or 301B/1
CV1988/Rispens

Question 17

MDV virus are administered and hatch via subcutaneous to day old chicks or in ovo to embryos at the?

Answer 17

18th day of incubation

Question 18

A highly contagious neoplastic disease characterized by T-cell lymphomas and peripheral nerve enlargement

Answer 18

Marek’s Disease

Question 19

Common clinical sign of MDv

Answer 19

Leg paralysis

Question 20

Is a B cell lymphoma, occurring in chickens ~16 weeks or older

Answer 20

Lymphoid leukosis

Question 21

Avian leukosis viruses subgroups

Answer 21

A
B
C
D
J
K

Question 22

subgroups which is being the most prevalent and pathogenic, causing lymphoid leukosis and other tumors in Chickens

Answer 22

A
B
J

Question 23

The natural hosts of Avian Leukosis Virus

Answer 23

Chickens

Question 24

A clonal malignancy ofnthe bursal-dependent lymphoid system.

Answer 24

Lymphoid leukosis

Question 25

Lymphoid leukosis transformation invariably occurs in the intact cloacal bursa, often as early as?

Answer 25

4-8 weeks after infection

Question 26

Chickens lymphoid leukosis have few typical clinical signs these may include:

Answer 26

Inappetence Weakness Diarrhea Dehydration Emaciation

Question 27

Often reveals an enlarged cloacal bursa and sometimes an enlarged liver

Answer 27

Palpation

Question 28

The tumors are found in birds?

Answer 28

> 14 weeks old